Multi-omic single-cell snapshots reveal multiple independent trajectories to drug tolerance in a melanoma cell line

Detailed understanding of how cancer cells transition from a drug sensitive to a tolerant state is lacking. Here, using single cell proteomic and metabolic data the authors uncover that isogenic BRAF mutant melanoma cells can take two distinct paths to become tolerant to BRAF inhibition.

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Autores principales:	Yapeng Su, Melissa E. Ko, Hanjun Cheng, Ronghui Zhu, Min Xue, Jessica Wang, Jihoon W. Lee, Luke Frankiw, Alexander Xu, Stephanie Wong, Lidia Robert, Kaitlyn Takata, Dan Yuan, Yue Lu, Sui Huang, Antoni Ribas, Raphael Levine, Garry P. Nolan, Wei Wei, Sylvia K. Plevritis, Guideng Li, David Baltimore, James R. Heath
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ef83fd0a40a640fbb4a0b6caefb26789
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spelling	oai:doaj.org-article:ef83fd0a40a640fbb4a0b6caefb267892021-12-02T17:02:20ZMulti-omic single-cell snapshots reveal multiple independent trajectories to drug tolerance in a melanoma cell line10.1038/s41467-020-15956-92041-1723https://doaj.org/article/ef83fd0a40a640fbb4a0b6caefb267892020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15956-9https://doaj.org/toc/2041-1723Detailed understanding of how cancer cells transition from a drug sensitive to a tolerant state is lacking. Here, using single cell proteomic and metabolic data the authors uncover that isogenic BRAF mutant melanoma cells can take two distinct paths to become tolerant to BRAF inhibition.Yapeng SuMelissa E. KoHanjun ChengRonghui ZhuMin XueJessica WangJihoon W. LeeLuke FrankiwAlexander XuStephanie WongLidia RobertKaitlyn TakataDan YuanYue LuSui HuangAntoni RibasRaphael LevineGarry P. NolanWei WeiSylvia K. PlevritisGuideng LiDavid BaltimoreJames R. HeathNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yapeng Su Melissa E. Ko Hanjun Cheng Ronghui Zhu Min Xue Jessica Wang Jihoon W. Lee Luke Frankiw Alexander Xu Stephanie Wong Lidia Robert Kaitlyn Takata Dan Yuan Yue Lu Sui Huang Antoni Ribas Raphael Levine Garry P. Nolan Wei Wei Sylvia K. Plevritis Guideng Li David Baltimore James R. Heath Multi-omic single-cell snapshots reveal multiple independent trajectories to drug tolerance in a melanoma cell line
description	Detailed understanding of how cancer cells transition from a drug sensitive to a tolerant state is lacking. Here, using single cell proteomic and metabolic data the authors uncover that isogenic BRAF mutant melanoma cells can take two distinct paths to become tolerant to BRAF inhibition.
format	article
author	Yapeng Su Melissa E. Ko Hanjun Cheng Ronghui Zhu Min Xue Jessica Wang Jihoon W. Lee Luke Frankiw Alexander Xu Stephanie Wong Lidia Robert Kaitlyn Takata Dan Yuan Yue Lu Sui Huang Antoni Ribas Raphael Levine Garry P. Nolan Wei Wei Sylvia K. Plevritis Guideng Li David Baltimore James R. Heath
author_facet	Yapeng Su Melissa E. Ko Hanjun Cheng Ronghui Zhu Min Xue Jessica Wang Jihoon W. Lee Luke Frankiw Alexander Xu Stephanie Wong Lidia Robert Kaitlyn Takata Dan Yuan Yue Lu Sui Huang Antoni Ribas Raphael Levine Garry P. Nolan Wei Wei Sylvia K. Plevritis Guideng Li David Baltimore James R. Heath
author_sort	Yapeng Su
title	Multi-omic single-cell snapshots reveal multiple independent trajectories to drug tolerance in a melanoma cell line
title_short	Multi-omic single-cell snapshots reveal multiple independent trajectories to drug tolerance in a melanoma cell line
title_full	Multi-omic single-cell snapshots reveal multiple independent trajectories to drug tolerance in a melanoma cell line
title_fullStr	Multi-omic single-cell snapshots reveal multiple independent trajectories to drug tolerance in a melanoma cell line
title_full_unstemmed	Multi-omic single-cell snapshots reveal multiple independent trajectories to drug tolerance in a melanoma cell line
title_sort	multi-omic single-cell snapshots reveal multiple independent trajectories to drug tolerance in a melanoma cell line
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/ef83fd0a40a640fbb4a0b6caefb26789
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Multi-omic single-cell snapshots reveal multiple independent trajectories to drug tolerance in a melanoma cell line

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