Multi-omic single-cell snapshots reveal multiple independent trajectories to drug tolerance in a melanoma cell line

Detailed understanding of how cancer cells transition from a drug sensitive to a tolerant state is lacking. Here, using single cell proteomic and metabolic data the authors uncover that isogenic BRAF mutant melanoma cells can take two distinct paths to become tolerant to BRAF inhibition.

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Autores principales: Yapeng Su, Melissa E. Ko, Hanjun Cheng, Ronghui Zhu, Min Xue, Jessica Wang, Jihoon W. Lee, Luke Frankiw, Alexander Xu, Stephanie Wong, Lidia Robert, Kaitlyn Takata, Dan Yuan, Yue Lu, Sui Huang, Antoni Ribas, Raphael Levine, Garry P. Nolan, Wei Wei, Sylvia K. Plevritis, Guideng Li, David Baltimore, James R. Heath
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Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/ef83fd0a40a640fbb4a0b6caefb26789
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spelling oai:doaj.org-article:ef83fd0a40a640fbb4a0b6caefb267892021-12-02T17:02:20ZMulti-omic single-cell snapshots reveal multiple independent trajectories to drug tolerance in a melanoma cell line10.1038/s41467-020-15956-92041-1723https://doaj.org/article/ef83fd0a40a640fbb4a0b6caefb267892020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15956-9https://doaj.org/toc/2041-1723Detailed understanding of how cancer cells transition from a drug sensitive to a tolerant state is lacking. Here, using single cell proteomic and metabolic data the authors uncover that isogenic BRAF mutant melanoma cells can take two distinct paths to become tolerant to BRAF inhibition.Yapeng SuMelissa E. KoHanjun ChengRonghui ZhuMin XueJessica WangJihoon W. LeeLuke FrankiwAlexander XuStephanie WongLidia RobertKaitlyn TakataDan YuanYue LuSui HuangAntoni RibasRaphael LevineGarry P. NolanWei WeiSylvia K. PlevritisGuideng LiDavid BaltimoreJames R. HeathNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Yapeng Su
Melissa E. Ko
Hanjun Cheng
Ronghui Zhu
Min Xue
Jessica Wang
Jihoon W. Lee
Luke Frankiw
Alexander Xu
Stephanie Wong
Lidia Robert
Kaitlyn Takata
Dan Yuan
Yue Lu
Sui Huang
Antoni Ribas
Raphael Levine
Garry P. Nolan
Wei Wei
Sylvia K. Plevritis
Guideng Li
David Baltimore
James R. Heath
Multi-omic single-cell snapshots reveal multiple independent trajectories to drug tolerance in a melanoma cell line
description Detailed understanding of how cancer cells transition from a drug sensitive to a tolerant state is lacking. Here, using single cell proteomic and metabolic data the authors uncover that isogenic BRAF mutant melanoma cells can take two distinct paths to become tolerant to BRAF inhibition.
format article
author Yapeng Su
Melissa E. Ko
Hanjun Cheng
Ronghui Zhu
Min Xue
Jessica Wang
Jihoon W. Lee
Luke Frankiw
Alexander Xu
Stephanie Wong
Lidia Robert
Kaitlyn Takata
Dan Yuan
Yue Lu
Sui Huang
Antoni Ribas
Raphael Levine
Garry P. Nolan
Wei Wei
Sylvia K. Plevritis
Guideng Li
David Baltimore
James R. Heath
author_facet Yapeng Su
Melissa E. Ko
Hanjun Cheng
Ronghui Zhu
Min Xue
Jessica Wang
Jihoon W. Lee
Luke Frankiw
Alexander Xu
Stephanie Wong
Lidia Robert
Kaitlyn Takata
Dan Yuan
Yue Lu
Sui Huang
Antoni Ribas
Raphael Levine
Garry P. Nolan
Wei Wei
Sylvia K. Plevritis
Guideng Li
David Baltimore
James R. Heath
author_sort Yapeng Su
title Multi-omic single-cell snapshots reveal multiple independent trajectories to drug tolerance in a melanoma cell line
title_short Multi-omic single-cell snapshots reveal multiple independent trajectories to drug tolerance in a melanoma cell line
title_full Multi-omic single-cell snapshots reveal multiple independent trajectories to drug tolerance in a melanoma cell line
title_fullStr Multi-omic single-cell snapshots reveal multiple independent trajectories to drug tolerance in a melanoma cell line
title_full_unstemmed Multi-omic single-cell snapshots reveal multiple independent trajectories to drug tolerance in a melanoma cell line
title_sort multi-omic single-cell snapshots reveal multiple independent trajectories to drug tolerance in a melanoma cell line
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/ef83fd0a40a640fbb4a0b6caefb26789
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