Multi-omic single-cell snapshots reveal multiple independent trajectories to drug tolerance in a melanoma cell line
Detailed understanding of how cancer cells transition from a drug sensitive to a tolerant state is lacking. Here, using single cell proteomic and metabolic data the authors uncover that isogenic BRAF mutant melanoma cells can take two distinct paths to become tolerant to BRAF inhibition.
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Nature Portfolio
2020
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oai:doaj.org-article:ef83fd0a40a640fbb4a0b6caefb267892021-12-02T17:02:20ZMulti-omic single-cell snapshots reveal multiple independent trajectories to drug tolerance in a melanoma cell line10.1038/s41467-020-15956-92041-1723https://doaj.org/article/ef83fd0a40a640fbb4a0b6caefb267892020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15956-9https://doaj.org/toc/2041-1723Detailed understanding of how cancer cells transition from a drug sensitive to a tolerant state is lacking. Here, using single cell proteomic and metabolic data the authors uncover that isogenic BRAF mutant melanoma cells can take two distinct paths to become tolerant to BRAF inhibition.Yapeng SuMelissa E. KoHanjun ChengRonghui ZhuMin XueJessica WangJihoon W. LeeLuke FrankiwAlexander XuStephanie WongLidia RobertKaitlyn TakataDan YuanYue LuSui HuangAntoni RibasRaphael LevineGarry P. NolanWei WeiSylvia K. PlevritisGuideng LiDavid BaltimoreJames R. HeathNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020) |
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DOAJ |
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DOAJ |
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EN |
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Science Q |
spellingShingle |
Science Q Yapeng Su Melissa E. Ko Hanjun Cheng Ronghui Zhu Min Xue Jessica Wang Jihoon W. Lee Luke Frankiw Alexander Xu Stephanie Wong Lidia Robert Kaitlyn Takata Dan Yuan Yue Lu Sui Huang Antoni Ribas Raphael Levine Garry P. Nolan Wei Wei Sylvia K. Plevritis Guideng Li David Baltimore James R. Heath Multi-omic single-cell snapshots reveal multiple independent trajectories to drug tolerance in a melanoma cell line |
description |
Detailed understanding of how cancer cells transition from a drug sensitive to a tolerant state is lacking. Here, using single cell proteomic and metabolic data the authors uncover that isogenic BRAF mutant melanoma cells can take two distinct paths to become tolerant to BRAF inhibition. |
format |
article |
author |
Yapeng Su Melissa E. Ko Hanjun Cheng Ronghui Zhu Min Xue Jessica Wang Jihoon W. Lee Luke Frankiw Alexander Xu Stephanie Wong Lidia Robert Kaitlyn Takata Dan Yuan Yue Lu Sui Huang Antoni Ribas Raphael Levine Garry P. Nolan Wei Wei Sylvia K. Plevritis Guideng Li David Baltimore James R. Heath |
author_facet |
Yapeng Su Melissa E. Ko Hanjun Cheng Ronghui Zhu Min Xue Jessica Wang Jihoon W. Lee Luke Frankiw Alexander Xu Stephanie Wong Lidia Robert Kaitlyn Takata Dan Yuan Yue Lu Sui Huang Antoni Ribas Raphael Levine Garry P. Nolan Wei Wei Sylvia K. Plevritis Guideng Li David Baltimore James R. Heath |
author_sort |
Yapeng Su |
title |
Multi-omic single-cell snapshots reveal multiple independent trajectories to drug tolerance in a melanoma cell line |
title_short |
Multi-omic single-cell snapshots reveal multiple independent trajectories to drug tolerance in a melanoma cell line |
title_full |
Multi-omic single-cell snapshots reveal multiple independent trajectories to drug tolerance in a melanoma cell line |
title_fullStr |
Multi-omic single-cell snapshots reveal multiple independent trajectories to drug tolerance in a melanoma cell line |
title_full_unstemmed |
Multi-omic single-cell snapshots reveal multiple independent trajectories to drug tolerance in a melanoma cell line |
title_sort |
multi-omic single-cell snapshots reveal multiple independent trajectories to drug tolerance in a melanoma cell line |
publisher |
Nature Portfolio |
publishDate |
2020 |
url |
https://doaj.org/article/ef83fd0a40a640fbb4a0b6caefb26789 |
work_keys_str_mv |
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