Transdermal Patches for Delivery of Beta-Blockers
Transdermal matrices containing 1.258 mg/cm2 of propranolol and consisting of ethylcellulose (EC), castor oil, and hydroxypropylmethylcellulose (HPMC) or halloysite (HA) were prepared. They were evaluated by tests such as folding endurance, moisture content and absorption, and paddle dissolution tes...
Guardado en:
| Autores principales: | , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Sciendo
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/ef854997127245a7b27e5023d42cfdad |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| Sumario: | Transdermal matrices containing 1.258 mg/cm2 of propranolol and consisting of ethylcellulose (EC), castor oil, and hydroxypropylmethylcellulose (HPMC) or halloysite (HA) were prepared. They were evaluated by tests such as folding endurance, moisture content and absorption, and paddle dissolution test. Of the total amount of propranolol in the samples (20 mg), 28.41% ± 3.30% was released from the EC film after 24 hours, the addition of HA 20.94% ± 1.52% (f1 = 61.82 ± 7.70, f2 = 53.61 ± 4.25) or HPMC 36.05% ± 6.18% (f1 = 34.48 ± 8.79, f2 = 65.02 ± 5.33). The dissolution profiles of HA and HPMC films were compared with each other (f1 = 51.35 ± 12.56, f2 = 59.20 ± 9.43). |
|---|