Transdermal Patches for Delivery of Beta-Blockers

Transdermal matrices containing 1.258 mg/cm2 of propranolol and consisting of ethylcellulose (EC), castor oil, and hydroxypropylmethylcellulose (HPMC) or halloysite (HA) were prepared. They were evaluated by tests such as folding endurance, moisture content and absorption, and paddle dissolution tes...

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Autores principales:	Rohaľová S., Guman M., Wolaschka T.
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2021
Materias:	ethylcellulose halloysite hypromellose propranolol transdermal therapeutic system Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/ef854997127245a7b27e5023d42cfdad
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spelling	oai:doaj.org-article:ef854997127245a7b27e5023d42cfdad2021-12-05T14:11:05ZTransdermal Patches for Delivery of Beta-Blockers2453-672510.2478/afpuc-2021-0007https://doaj.org/article/ef854997127245a7b27e5023d42cfdad2021-07-01T00:00:00Zhttps://doi.org/10.2478/afpuc-2021-0007https://doaj.org/toc/2453-6725Transdermal matrices containing 1.258 mg/cm2 of propranolol and consisting of ethylcellulose (EC), castor oil, and hydroxypropylmethylcellulose (HPMC) or halloysite (HA) were prepared. They were evaluated by tests such as folding endurance, moisture content and absorption, and paddle dissolution test. Of the total amount of propranolol in the samples (20 mg), 28.41% ± 3.30% was released from the EC film after 24 hours, the addition of HA 20.94% ± 1.52% (f1 = 61.82 ± 7.70, f2 = 53.61 ± 4.25) or HPMC 36.05% ± 6.18% (f1 = 34.48 ± 8.79, f2 = 65.02 ± 5.33). The dissolution profiles of HA and HPMC films were compared with each other (f1 = 51.35 ± 12.56, f2 = 59.20 ± 9.43).Rohaľová S.Guman M.Wolaschka T.Sciendoarticleethylcellulosehalloysitehypromellosepropranololtransdermal therapeutic systemTherapeutics. PharmacologyRM1-950ENEuropean Pharmaceutical Journal, Vol 68, Iss 1, Pp 80-83 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ethylcellulose halloysite hypromellose propranolol transdermal therapeutic system Therapeutics. Pharmacology RM1-950
spellingShingle	ethylcellulose halloysite hypromellose propranolol transdermal therapeutic system Therapeutics. Pharmacology RM1-950 Rohaľová S. Guman M. Wolaschka T. Transdermal Patches for Delivery of Beta-Blockers
description	Transdermal matrices containing 1.258 mg/cm2 of propranolol and consisting of ethylcellulose (EC), castor oil, and hydroxypropylmethylcellulose (HPMC) or halloysite (HA) were prepared. They were evaluated by tests such as folding endurance, moisture content and absorption, and paddle dissolution test. Of the total amount of propranolol in the samples (20 mg), 28.41% ± 3.30% was released from the EC film after 24 hours, the addition of HA 20.94% ± 1.52% (f1 = 61.82 ± 7.70, f2 = 53.61 ± 4.25) or HPMC 36.05% ± 6.18% (f1 = 34.48 ± 8.79, f2 = 65.02 ± 5.33). The dissolution profiles of HA and HPMC films were compared with each other (f1 = 51.35 ± 12.56, f2 = 59.20 ± 9.43).
format	article
author	Rohaľová S. Guman M. Wolaschka T.
author_facet	Rohaľová S. Guman M. Wolaschka T.
author_sort	Rohaľová S.
title	Transdermal Patches for Delivery of Beta-Blockers
title_short	Transdermal Patches for Delivery of Beta-Blockers
title_full	Transdermal Patches for Delivery of Beta-Blockers
title_fullStr	Transdermal Patches for Delivery of Beta-Blockers
title_full_unstemmed	Transdermal Patches for Delivery of Beta-Blockers
title_sort	transdermal patches for delivery of beta-blockers
publisher	Sciendo
publishDate	2021
url	https://doaj.org/article/ef854997127245a7b27e5023d42cfdad
work_keys_str_mv	AT rohalovas transdermalpatchesfordeliveryofbetablockers AT gumanm transdermalpatchesfordeliveryofbetablockers AT wolaschkat transdermalpatchesfordeliveryofbetablockers
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Transdermal Patches for Delivery of Beta-Blockers

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