Nanocrystal facet modulation to enhance transferrin binding and cellular delivery

Modulation of exposed crystal facets enhances transferrin binding to chalcogenide nanocrystals and their subsequent delivery into cancer cells. Facet-dependent protein binding occurs through inner-sphere thiol complexation and is affected by the structure of the first solvation shell.

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Autores principales: Yu Qi, Tong Zhang, Chuanyong Jing, Sijin Liu, Chengdong Zhang, Pedro J. J. Alvarez, Wei Chen
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/ef85a9a2b3904083a9ff5d35f3a94434
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spelling oai:doaj.org-article:ef85a9a2b3904083a9ff5d35f3a944342021-12-02T16:49:28ZNanocrystal facet modulation to enhance transferrin binding and cellular delivery10.1038/s41467-020-14972-z2041-1723https://doaj.org/article/ef85a9a2b3904083a9ff5d35f3a944342020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14972-zhttps://doaj.org/toc/2041-1723Modulation of exposed crystal facets enhances transferrin binding to chalcogenide nanocrystals and their subsequent delivery into cancer cells. Facet-dependent protein binding occurs through inner-sphere thiol complexation and is affected by the structure of the first solvation shell.Yu QiTong ZhangChuanyong JingSijin LiuChengdong ZhangPedro J. J. AlvarezWei ChenNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Yu Qi
Tong Zhang
Chuanyong Jing
Sijin Liu
Chengdong Zhang
Pedro J. J. Alvarez
Wei Chen
Nanocrystal facet modulation to enhance transferrin binding and cellular delivery
description Modulation of exposed crystal facets enhances transferrin binding to chalcogenide nanocrystals and their subsequent delivery into cancer cells. Facet-dependent protein binding occurs through inner-sphere thiol complexation and is affected by the structure of the first solvation shell.
format article
author Yu Qi
Tong Zhang
Chuanyong Jing
Sijin Liu
Chengdong Zhang
Pedro J. J. Alvarez
Wei Chen
author_facet Yu Qi
Tong Zhang
Chuanyong Jing
Sijin Liu
Chengdong Zhang
Pedro J. J. Alvarez
Wei Chen
author_sort Yu Qi
title Nanocrystal facet modulation to enhance transferrin binding and cellular delivery
title_short Nanocrystal facet modulation to enhance transferrin binding and cellular delivery
title_full Nanocrystal facet modulation to enhance transferrin binding and cellular delivery
title_fullStr Nanocrystal facet modulation to enhance transferrin binding and cellular delivery
title_full_unstemmed Nanocrystal facet modulation to enhance transferrin binding and cellular delivery
title_sort nanocrystal facet modulation to enhance transferrin binding and cellular delivery
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/ef85a9a2b3904083a9ff5d35f3a94434
work_keys_str_mv AT yuqi nanocrystalfacetmodulationtoenhancetransferrinbindingandcellulardelivery
AT tongzhang nanocrystalfacetmodulationtoenhancetransferrinbindingandcellulardelivery
AT chuanyongjing nanocrystalfacetmodulationtoenhancetransferrinbindingandcellulardelivery
AT sijinliu nanocrystalfacetmodulationtoenhancetransferrinbindingandcellulardelivery
AT chengdongzhang nanocrystalfacetmodulationtoenhancetransferrinbindingandcellulardelivery
AT pedrojjalvarez nanocrystalfacetmodulationtoenhancetransferrinbindingandcellulardelivery
AT weichen nanocrystalfacetmodulationtoenhancetransferrinbindingandcellulardelivery
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