Green nanotechnology of MGF-AuNPs for immunomodulatory intervention in prostate cancer therapy

Abstract Men with castration-resistant prostate cancer (CRPC) face poor prognosis and increased risk of treatment-incurred adverse effects resulting in one of the highest mortalities among patient population globally. Immune cells act as double-edged sword depending on the tumor microenvironment, wh...

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Autores principales:	Menka Khoobchandani, Aslam Khan, Kavita K. Katti, Velaphi C. Thipe, Amal Y. Al-Yasiri, Darsha K. D. MohanDoss, Michael B. Nicholl, Ademar B. Lugão, Chetan P. Hans, Kattesh V. Katti
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ef899c3a3d244a9498313b92a71d0d3c
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spelling	oai:doaj.org-article:ef899c3a3d244a9498313b92a71d0d3c2021-12-02T16:45:40ZGreen nanotechnology of MGF-AuNPs for immunomodulatory intervention in prostate cancer therapy10.1038/s41598-021-96224-82045-2322https://doaj.org/article/ef899c3a3d244a9498313b92a71d0d3c2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96224-8https://doaj.org/toc/2045-2322Abstract Men with castration-resistant prostate cancer (CRPC) face poor prognosis and increased risk of treatment-incurred adverse effects resulting in one of the highest mortalities among patient population globally. Immune cells act as double-edged sword depending on the tumor microenvironment, which leads to increased infiltration of pro-tumor (M2) macrophages. Development of new immunomodulatory therapeutic agents capable of targeting the tumor microenvironment, and hence orchestrating the transformation of pro-tumor M2 macrophages to anti-tumor M1, would substantially improve treatment outcomes of CRPC patients. We report, herein, Mangiferin functionalized gold nanoparticulate agent (MGF-AuNPs) and its immunomodulatory characteristics in treating prostate cancer. We provide evidence of immunomodulatory intervention of MGF-AuNPs in prostate cancers through observations of enhanced levels of anti-tumor cytokines (IL-12 and TNF-α) with concomitant reductions in the levels of pro-tumor cytokines (IL-10 and IL-6). In the MGF-AuNPs treated groups, IL-12 was elevated to ten-fold while TNF-α was elevated to about 50-fold, while IL-10 and IL-6 were reduced by two-fold. Ability of MGF-AuNPs to target splenic macrophages is invoked via targeting of NF-kB signaling pathway. Finally, therapeutic efficacy of MGF-AuNPs, in treating prostate cancer in vivo in tumor bearing mice, is described taking into consideration various immunomodulatory interventions triggered by this green nanotechnology-based nanomedicine agent.Menka KhoobchandaniAslam KhanKavita K. KattiVelaphi C. ThipeAmal Y. Al-YasiriDarsha K. D. MohanDossMichael B. NichollAdemar B. LugãoChetan P. HansKattesh V. KattiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-30 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Menka Khoobchandani Aslam Khan Kavita K. Katti Velaphi C. Thipe Amal Y. Al-Yasiri Darsha K. D. MohanDoss Michael B. Nicholl Ademar B. Lugão Chetan P. Hans Kattesh V. Katti Green nanotechnology of MGF-AuNPs for immunomodulatory intervention in prostate cancer therapy
description	Abstract Men with castration-resistant prostate cancer (CRPC) face poor prognosis and increased risk of treatment-incurred adverse effects resulting in one of the highest mortalities among patient population globally. Immune cells act as double-edged sword depending on the tumor microenvironment, which leads to increased infiltration of pro-tumor (M2) macrophages. Development of new immunomodulatory therapeutic agents capable of targeting the tumor microenvironment, and hence orchestrating the transformation of pro-tumor M2 macrophages to anti-tumor M1, would substantially improve treatment outcomes of CRPC patients. We report, herein, Mangiferin functionalized gold nanoparticulate agent (MGF-AuNPs) and its immunomodulatory characteristics in treating prostate cancer. We provide evidence of immunomodulatory intervention of MGF-AuNPs in prostate cancers through observations of enhanced levels of anti-tumor cytokines (IL-12 and TNF-α) with concomitant reductions in the levels of pro-tumor cytokines (IL-10 and IL-6). In the MGF-AuNPs treated groups, IL-12 was elevated to ten-fold while TNF-α was elevated to about 50-fold, while IL-10 and IL-6 were reduced by two-fold. Ability of MGF-AuNPs to target splenic macrophages is invoked via targeting of NF-kB signaling pathway. Finally, therapeutic efficacy of MGF-AuNPs, in treating prostate cancer in vivo in tumor bearing mice, is described taking into consideration various immunomodulatory interventions triggered by this green nanotechnology-based nanomedicine agent.
format	article
author	Menka Khoobchandani Aslam Khan Kavita K. Katti Velaphi C. Thipe Amal Y. Al-Yasiri Darsha K. D. MohanDoss Michael B. Nicholl Ademar B. Lugão Chetan P. Hans Kattesh V. Katti
author_facet	Menka Khoobchandani Aslam Khan Kavita K. Katti Velaphi C. Thipe Amal Y. Al-Yasiri Darsha K. D. MohanDoss Michael B. Nicholl Ademar B. Lugão Chetan P. Hans Kattesh V. Katti
author_sort	Menka Khoobchandani
title	Green nanotechnology of MGF-AuNPs for immunomodulatory intervention in prostate cancer therapy
title_short	Green nanotechnology of MGF-AuNPs for immunomodulatory intervention in prostate cancer therapy
title_full	Green nanotechnology of MGF-AuNPs for immunomodulatory intervention in prostate cancer therapy
title_fullStr	Green nanotechnology of MGF-AuNPs for immunomodulatory intervention in prostate cancer therapy
title_full_unstemmed	Green nanotechnology of MGF-AuNPs for immunomodulatory intervention in prostate cancer therapy
title_sort	green nanotechnology of mgf-aunps for immunomodulatory intervention in prostate cancer therapy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ef899c3a3d244a9498313b92a71d0d3c
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Green nanotechnology of MGF-AuNPs for immunomodulatory intervention in prostate cancer therapy

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