Novel pH-sensitive zinc phthalocyanine assembled with albumin for tumor targeting and treatment

Ying Wang,1,2 Ke Zheng,1 Guangshan Xuan,1 Mingdong Huang,3 Jinping Xue3 1College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao, Shandong, China; 2Key Lab of Inorganic Synthetic and Applied Chemistry, State Key Lab Base of Eco-Chemical Engineering, College of Chemist...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Wang Y, Zheng K, Xuan G, Huang M, Xue J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	photodynamic therapy drug delivery system chemotherapy antitumor activity Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/ef8a53ce9c4549c196c103122a67f673
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ef8a53ce9c4549c196c103122a67f673
record_format	dspace
spelling	oai:doaj.org-article:ef8a53ce9c4549c196c103122a67f6732021-12-02T03:49:59ZNovel pH-sensitive zinc phthalocyanine assembled with albumin for tumor targeting and treatment1178-2013https://doaj.org/article/ef8a53ce9c4549c196c103122a67f6732018-11-01T00:00:00Zhttps://www.dovepress.com/novel-ph-sensitive-zinc-phthalocyanine-assembled-with-albumin-for-tumo-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Ying Wang,1,2 Ke Zheng,1 Guangshan Xuan,1 Mingdong Huang,3 Jinping Xue3 1College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao, Shandong, China; 2Key Lab of Inorganic Synthetic and Applied Chemistry, State Key Lab Base of Eco-Chemical Engineering, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao, Shandong, China; 3College of Chemistry, Fuzhou University, Fuzhou, Fujian, China Purpose: Zinc phthalocyanine (ZnPc) has been applied widely in photodynamic therapy (PDT) with high ROS-production capacity and intense absorption in the near-infrared region. However, weak tumor targeting and the aggregation tendency of ZnPc seriously affect the therapeutic effect of PDT. Therefore, overcoming the aggregation of ZnPc and enhancing its antitumor effect were the purpose of this study.Methods: In this study, we first found that the aggregation behaviors of the photosensitizer ZnPc(TAP)4, ZnPc substituted by tertiary amine groups, were regulated finely by pH and that ZnPc(TAP)4 could be disaggregated gradually as the pH descended. ZnPc(TAP)4 and human serum albumin (HSA) molecules were assembled into nanoparticles (NPs) for tumor targeting. Meanwhile, the chemotherapy drug paclitaxel (Ptx) was loaded into HSA NPs together with ZnPc(TAP)4 for dual antitumor effects. HSA NPs loading both ZnPc(TAP)4 and Ptx (NP–ZnPc[TAP]4–Ptx) were characterized by particle size and in vitro release. Cytotoxicity, subcellular localization, tumor targeting, and anticancer effect in vivo were investigated respectively.Results: We found that NP–ZnPc(TAP)4–Ptx had good stability with qualifying particle size. Interestingly, ZnPc(TAP)4 was released from the NPs and the photodynamic activity enhanced in the acidic environment of tumor. In addition, NP–ZnPc(TAP)4–Ptx had prominent cytotoxicity and time-dependent subcellular localization characteristics. Through a three-dimensional animal imaging system, NP–ZnPc(TAP)4–Ptx showed much-enhanced tumor targeting in tumor-bearing mice. Above all, NP–ZnPc(TAP)4–Ptx was demonstrated to have the synergistic anticancer effect of PDT and chemotherapy.Conclusion: NP–ZnPc(TAP)4–Ptx had enhanced tumor targeting for the pH-sensitive property of ZnPc(TAP)4 and the transport function of HSA. NP–ZnPc(TAP)4–Ptx possessed a double-anticancer effect through the combination of ZnPc(TAP)4 and Ptx. This drug-delivery system may also be used to carry chemotherapy drugs other than Ptx for improving antitumor effects. Keywords: photodynamic therapy, drug-delivery system, controlled release, chemotherapy, antitumor activity, combination therapyWang YZheng KXuan GHuang MXue JDove Medical Pressarticlephotodynamic therapydrug delivery systemchemotherapyantitumor activityMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 7681-7695 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	photodynamic therapy drug delivery system chemotherapy antitumor activity Medicine (General) R5-920
spellingShingle	photodynamic therapy drug delivery system chemotherapy antitumor activity Medicine (General) R5-920 Wang Y Zheng K Xuan G Huang M Xue J Novel pH-sensitive zinc phthalocyanine assembled with albumin for tumor targeting and treatment
description	Ying Wang,1,2 Ke Zheng,1 Guangshan Xuan,1 Mingdong Huang,3 Jinping Xue3 1College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao, Shandong, China; 2Key Lab of Inorganic Synthetic and Applied Chemistry, State Key Lab Base of Eco-Chemical Engineering, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao, Shandong, China; 3College of Chemistry, Fuzhou University, Fuzhou, Fujian, China Purpose: Zinc phthalocyanine (ZnPc) has been applied widely in photodynamic therapy (PDT) with high ROS-production capacity and intense absorption in the near-infrared region. However, weak tumor targeting and the aggregation tendency of ZnPc seriously affect the therapeutic effect of PDT. Therefore, overcoming the aggregation of ZnPc and enhancing its antitumor effect were the purpose of this study.Methods: In this study, we first found that the aggregation behaviors of the photosensitizer ZnPc(TAP)4, ZnPc substituted by tertiary amine groups, were regulated finely by pH and that ZnPc(TAP)4 could be disaggregated gradually as the pH descended. ZnPc(TAP)4 and human serum albumin (HSA) molecules were assembled into nanoparticles (NPs) for tumor targeting. Meanwhile, the chemotherapy drug paclitaxel (Ptx) was loaded into HSA NPs together with ZnPc(TAP)4 for dual antitumor effects. HSA NPs loading both ZnPc(TAP)4 and Ptx (NP–ZnPc[TAP]4–Ptx) were characterized by particle size and in vitro release. Cytotoxicity, subcellular localization, tumor targeting, and anticancer effect in vivo were investigated respectively.Results: We found that NP–ZnPc(TAP)4–Ptx had good stability with qualifying particle size. Interestingly, ZnPc(TAP)4 was released from the NPs and the photodynamic activity enhanced in the acidic environment of tumor. In addition, NP–ZnPc(TAP)4–Ptx had prominent cytotoxicity and time-dependent subcellular localization characteristics. Through a three-dimensional animal imaging system, NP–ZnPc(TAP)4–Ptx showed much-enhanced tumor targeting in tumor-bearing mice. Above all, NP–ZnPc(TAP)4–Ptx was demonstrated to have the synergistic anticancer effect of PDT and chemotherapy.Conclusion: NP–ZnPc(TAP)4–Ptx had enhanced tumor targeting for the pH-sensitive property of ZnPc(TAP)4 and the transport function of HSA. NP–ZnPc(TAP)4–Ptx possessed a double-anticancer effect through the combination of ZnPc(TAP)4 and Ptx. This drug-delivery system may also be used to carry chemotherapy drugs other than Ptx for improving antitumor effects. Keywords: photodynamic therapy, drug-delivery system, controlled release, chemotherapy, antitumor activity, combination therapy
format	article
author	Wang Y Zheng K Xuan G Huang M Xue J
author_facet	Wang Y Zheng K Xuan G Huang M Xue J
author_sort	Wang Y
title	Novel pH-sensitive zinc phthalocyanine assembled with albumin for tumor targeting and treatment
title_short	Novel pH-sensitive zinc phthalocyanine assembled with albumin for tumor targeting and treatment
title_full	Novel pH-sensitive zinc phthalocyanine assembled with albumin for tumor targeting and treatment
title_fullStr	Novel pH-sensitive zinc phthalocyanine assembled with albumin for tumor targeting and treatment
title_full_unstemmed	Novel pH-sensitive zinc phthalocyanine assembled with albumin for tumor targeting and treatment
title_sort	novel ph-sensitive zinc phthalocyanine assembled with albumin for tumor targeting and treatment
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/ef8a53ce9c4549c196c103122a67f673
work_keys_str_mv	AT wangy novelphsensitivezincphthalocyanineassembledwithalbuminfortumortargetingandtreatment AT zhengk novelphsensitivezincphthalocyanineassembledwithalbuminfortumortargetingandtreatment AT xuang novelphsensitivezincphthalocyanineassembledwithalbuminfortumortargetingandtreatment AT huangm novelphsensitivezincphthalocyanineassembledwithalbuminfortumortargetingandtreatment AT xuej novelphsensitivezincphthalocyanineassembledwithalbuminfortumortargetingandtreatment
_version_	1718401620632403968

Novel pH-sensitive zinc phthalocyanine assembled with albumin for tumor targeting and treatment

Ejemplares similares