Cellular uptake of proMMP-2:TIMP-2 complexes by the endocytic receptor megalin/LRP-2

Cellular uptake of proMMP-2:TIMP-2 complexes by the endocytic receptor megalin/LRP-2

Abstract Matrix metalloproteinases (MMPs) are regulated at multiple transcriptional and post-transcriptional levels, among which receptor-mediated endocytic clearance. We previously showed that low-density lipoprotein receptor-related protein-1 (LRP-1) mediates the clearance of a complex between the...

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Autores principales: Manuel Johanns, Pascale Lemoine, Virginie Janssens, Giuseppina Grieco, Soren K. Moestrup, Rikke Nielsen, Erik I. Christensen, Pierre J. Courtoy, Hervé Emonard, Etienne Marbaix, Patrick Henriet
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Medicine
R
Science
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Acceso en línea:https://doaj.org/article/ef8ab5cbd1544d42a3b9b4dc04fabb65
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