Loco-regional deep hyperthermia combined with intravesical Mitomycin instillation reduces the recurrence of non-muscle invasive papillary bladder cancer

Objectives To compare the therapeutic effects of locoregional deep hyperthermia combined with intravesical chemotherapy with those of intravesical chemotherapy alone in patients with intermediate-/high-risk non-muscle invasive bladder cancer (NMIBC). To evaluate the impact of thermal dose in hyperth...

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Autores principales:	Yu-Ching Wen, Liang-Ming Lee, Yung-Wei Lin, Syuan-Hao Syu, Ke-Hsun Lin, Yen-Chun Fan, Hsin-Lun Lee, Benjamin Chung Howe Lai, Hung-Jen Shih
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	mitomycin hyperthermia bladder cancer recurrence thermal dose Medical technology R855-855.5
Acceso en línea:	https://doaj.org/article/ef8eb434c29f47f7921177420b1a3c34
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spelling	oai:doaj.org-article:ef8eb434c29f47f7921177420b1a3c342021-11-17T14:21:55ZLoco-regional deep hyperthermia combined with intravesical Mitomycin instillation reduces the recurrence of non-muscle invasive papillary bladder cancer0265-67361464-515710.1080/02656736.2021.2001582https://doaj.org/article/ef8eb434c29f47f7921177420b1a3c342021-01-01T00:00:00Zhttp://dx.doi.org/10.1080/02656736.2021.2001582https://doaj.org/toc/0265-6736https://doaj.org/toc/1464-5157Objectives To compare the therapeutic effects of locoregional deep hyperthermia combined with intravesical chemotherapy with those of intravesical chemotherapy alone in patients with intermediate-/high-risk non-muscle invasive bladder cancer (NMIBC). To evaluate the impact of thermal dose in hyperthermia treatment. Methods We analyzed data retrieved from the medical records of patients with intermediate-/high-risk NMIBC treated with intravesical mitomycin (IM group) or locoregional deep hyperthermia combined with intravesical mitomycin (CHT group) at a single tertiary care hospital between May 2016 and June 2019. The primary and secondary endpoints were the recurrence-free survival rate and progression-free survival rate, respectively. Thermal dose was evaluated and adverse events were also recorded. Results In total, 43 patients (CHT: 18 patients, IM: 25 patients) were enrolled. The median follow-up durations were 14 and 23 months, respectively. The recurrence rate at 12 months was significantly lower in the CHT group than in the IM group (11.1% vs. 44%, p = .048); this trend persisted at 24 months (CHT: 11.1%, IM: 48%; p = .027). The recurrence-free survival was also significantly higher in the CHT group than in the IM group (p = .028). No tumor recurrence was noted in patients who received a thermal dose of ≥4 CEM43. All adverse events were well tolerated, and there was no treatment-related mortality. Conclusions Intravesical chemotherapy combined with locoregional deep hyperthermia for intermediate-/high-risk papillary NMIBC can significantly decrease the recurrence rate relative to that observed after intravesical chemotherapy alone.Yu-Ching WenLiang-Ming LeeYung-Wei LinSyuan-Hao SyuKe-Hsun LinYen-Chun FanHsin-Lun LeeBenjamin Chung Howe LaiHung-Jen ShihTaylor & Francis Grouparticlemitomycinhyperthermiabladder cancerrecurrencethermal doseMedical technologyR855-855.5ENInternational Journal of Hyperthermia, Vol 38, Iss 1, Pp 1627-1632 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	mitomycin hyperthermia bladder cancer recurrence thermal dose Medical technology R855-855.5
spellingShingle	mitomycin hyperthermia bladder cancer recurrence thermal dose Medical technology R855-855.5 Yu-Ching Wen Liang-Ming Lee Yung-Wei Lin Syuan-Hao Syu Ke-Hsun Lin Yen-Chun Fan Hsin-Lun Lee Benjamin Chung Howe Lai Hung-Jen Shih Loco-regional deep hyperthermia combined with intravesical Mitomycin instillation reduces the recurrence of non-muscle invasive papillary bladder cancer
description	Objectives To compare the therapeutic effects of locoregional deep hyperthermia combined with intravesical chemotherapy with those of intravesical chemotherapy alone in patients with intermediate-/high-risk non-muscle invasive bladder cancer (NMIBC). To evaluate the impact of thermal dose in hyperthermia treatment. Methods We analyzed data retrieved from the medical records of patients with intermediate-/high-risk NMIBC treated with intravesical mitomycin (IM group) or locoregional deep hyperthermia combined with intravesical mitomycin (CHT group) at a single tertiary care hospital between May 2016 and June 2019. The primary and secondary endpoints were the recurrence-free survival rate and progression-free survival rate, respectively. Thermal dose was evaluated and adverse events were also recorded. Results In total, 43 patients (CHT: 18 patients, IM: 25 patients) were enrolled. The median follow-up durations were 14 and 23 months, respectively. The recurrence rate at 12 months was significantly lower in the CHT group than in the IM group (11.1% vs. 44%, p = .048); this trend persisted at 24 months (CHT: 11.1%, IM: 48%; p = .027). The recurrence-free survival was also significantly higher in the CHT group than in the IM group (p = .028). No tumor recurrence was noted in patients who received a thermal dose of ≥4 CEM43. All adverse events were well tolerated, and there was no treatment-related mortality. Conclusions Intravesical chemotherapy combined with locoregional deep hyperthermia for intermediate-/high-risk papillary NMIBC can significantly decrease the recurrence rate relative to that observed after intravesical chemotherapy alone.
format	article
author	Yu-Ching Wen Liang-Ming Lee Yung-Wei Lin Syuan-Hao Syu Ke-Hsun Lin Yen-Chun Fan Hsin-Lun Lee Benjamin Chung Howe Lai Hung-Jen Shih
author_facet	Yu-Ching Wen Liang-Ming Lee Yung-Wei Lin Syuan-Hao Syu Ke-Hsun Lin Yen-Chun Fan Hsin-Lun Lee Benjamin Chung Howe Lai Hung-Jen Shih
author_sort	Yu-Ching Wen
title	Loco-regional deep hyperthermia combined with intravesical Mitomycin instillation reduces the recurrence of non-muscle invasive papillary bladder cancer
title_short	Loco-regional deep hyperthermia combined with intravesical Mitomycin instillation reduces the recurrence of non-muscle invasive papillary bladder cancer
title_full	Loco-regional deep hyperthermia combined with intravesical Mitomycin instillation reduces the recurrence of non-muscle invasive papillary bladder cancer
title_fullStr	Loco-regional deep hyperthermia combined with intravesical Mitomycin instillation reduces the recurrence of non-muscle invasive papillary bladder cancer
title_full_unstemmed	Loco-regional deep hyperthermia combined with intravesical Mitomycin instillation reduces the recurrence of non-muscle invasive papillary bladder cancer
title_sort	loco-regional deep hyperthermia combined with intravesical mitomycin instillation reduces the recurrence of non-muscle invasive papillary bladder cancer
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/ef8eb434c29f47f7921177420b1a3c34
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Loco-regional deep hyperthermia combined with intravesical Mitomycin instillation reduces the recurrence of non-muscle invasive papillary bladder cancer

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