Dehydration prompts increased activity and blood feeding by mosquitoes

Abstract Current insights into the mosquito dehydration response rely on studies that examine specific responses but ultimately fail to provide an encompassing view of mosquito biology. Here, we examined underlying changes in the biology of mosquitoes associated with dehydration. Specifically, we sh...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Richard W. Hagan, Elise M. Didion, Andrew E. Rosselot, Christopher J. Holmes, Samantha C. Siler, Andrew J. Rosendale, Jacob M. Hendershot, Kiaira S. B. Elliot, Emily C. Jennings, Gabriela A. Nine, Paula L. Perez, Alexandre E. Rizlallah, Miki Watanabe, Lindsey E. Romick-Rosendale, Yanyu Xiao, Jason L. Rasgon, Joshua B. Benoit
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ef8f3a1e2c8145fcaaa38d9e5e466167
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ef8f3a1e2c8145fcaaa38d9e5e466167
record_format	dspace
spelling	oai:doaj.org-article:ef8f3a1e2c8145fcaaa38d9e5e4661672021-12-02T15:08:03ZDehydration prompts increased activity and blood feeding by mosquitoes10.1038/s41598-018-24893-z2045-2322https://doaj.org/article/ef8f3a1e2c8145fcaaa38d9e5e4661672018-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-24893-zhttps://doaj.org/toc/2045-2322Abstract Current insights into the mosquito dehydration response rely on studies that examine specific responses but ultimately fail to provide an encompassing view of mosquito biology. Here, we examined underlying changes in the biology of mosquitoes associated with dehydration. Specifically, we show that dehydration increases blood feeding in the northern house mosquito, Culex pipiens, which was the result of both higher activity and a greater tendency to land on a host. Similar observations were noted for Aedes aegypti and Anopheles quadrimaculatus. RNA-seq and metabolome analyses in C. pipiens following dehydration revealed that factors associated with carbohydrate metabolism are altered, specifically the breakdown of trehalose. Suppression of trehalose breakdown in C. pipiens by RNA interference reduced phenotypes associated with lower hydration levels. Lastly, mesocosm studies for C. pipiens confirmed that dehydrated mosquitoes were more likely to host feed under ecologically relevant conditions. Disease modeling indicates dehydration bouts will likely enhance viral transmission. This dehydration-induced increase in blood feeding is therefore likely to occur regularly and intensify during periods when availability of water is low.Richard W. HaganElise M. DidionAndrew E. RosselotChristopher J. HolmesSamantha C. SilerAndrew J. RosendaleJacob M. HendershotKiaira S. B. ElliotEmily C. JenningsGabriela A. NinePaula L. PerezAlexandre E. RizlallahMiki WatanabeLindsey E. Romick-RosendaleYanyu XiaoJason L. RasgonJoshua B. BenoitNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Richard W. Hagan Elise M. Didion Andrew E. Rosselot Christopher J. Holmes Samantha C. Siler Andrew J. Rosendale Jacob M. Hendershot Kiaira S. B. Elliot Emily C. Jennings Gabriela A. Nine Paula L. Perez Alexandre E. Rizlallah Miki Watanabe Lindsey E. Romick-Rosendale Yanyu Xiao Jason L. Rasgon Joshua B. Benoit Dehydration prompts increased activity and blood feeding by mosquitoes
description	Abstract Current insights into the mosquito dehydration response rely on studies that examine specific responses but ultimately fail to provide an encompassing view of mosquito biology. Here, we examined underlying changes in the biology of mosquitoes associated with dehydration. Specifically, we show that dehydration increases blood feeding in the northern house mosquito, Culex pipiens, which was the result of both higher activity and a greater tendency to land on a host. Similar observations were noted for Aedes aegypti and Anopheles quadrimaculatus. RNA-seq and metabolome analyses in C. pipiens following dehydration revealed that factors associated with carbohydrate metabolism are altered, specifically the breakdown of trehalose. Suppression of trehalose breakdown in C. pipiens by RNA interference reduced phenotypes associated with lower hydration levels. Lastly, mesocosm studies for C. pipiens confirmed that dehydrated mosquitoes were more likely to host feed under ecologically relevant conditions. Disease modeling indicates dehydration bouts will likely enhance viral transmission. This dehydration-induced increase in blood feeding is therefore likely to occur regularly and intensify during periods when availability of water is low.
format	article
author	Richard W. Hagan Elise M. Didion Andrew E. Rosselot Christopher J. Holmes Samantha C. Siler Andrew J. Rosendale Jacob M. Hendershot Kiaira S. B. Elliot Emily C. Jennings Gabriela A. Nine Paula L. Perez Alexandre E. Rizlallah Miki Watanabe Lindsey E. Romick-Rosendale Yanyu Xiao Jason L. Rasgon Joshua B. Benoit
author_facet	Richard W. Hagan Elise M. Didion Andrew E. Rosselot Christopher J. Holmes Samantha C. Siler Andrew J. Rosendale Jacob M. Hendershot Kiaira S. B. Elliot Emily C. Jennings Gabriela A. Nine Paula L. Perez Alexandre E. Rizlallah Miki Watanabe Lindsey E. Romick-Rosendale Yanyu Xiao Jason L. Rasgon Joshua B. Benoit
author_sort	Richard W. Hagan
title	Dehydration prompts increased activity and blood feeding by mosquitoes
title_short	Dehydration prompts increased activity and blood feeding by mosquitoes
title_full	Dehydration prompts increased activity and blood feeding by mosquitoes
title_fullStr	Dehydration prompts increased activity and blood feeding by mosquitoes
title_full_unstemmed	Dehydration prompts increased activity and blood feeding by mosquitoes
title_sort	dehydration prompts increased activity and blood feeding by mosquitoes
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/ef8f3a1e2c8145fcaaa38d9e5e466167
work_keys_str_mv	AT richardwhagan dehydrationpromptsincreasedactivityandbloodfeedingbymosquitoes AT elisemdidion dehydrationpromptsincreasedactivityandbloodfeedingbymosquitoes AT andrewerosselot dehydrationpromptsincreasedactivityandbloodfeedingbymosquitoes AT christopherjholmes dehydrationpromptsincreasedactivityandbloodfeedingbymosquitoes AT samanthacsiler dehydrationpromptsincreasedactivityandbloodfeedingbymosquitoes AT andrewjrosendale dehydrationpromptsincreasedactivityandbloodfeedingbymosquitoes AT jacobmhendershot dehydrationpromptsincreasedactivityandbloodfeedingbymosquitoes AT kiairasbelliot dehydrationpromptsincreasedactivityandbloodfeedingbymosquitoes AT emilycjennings dehydrationpromptsincreasedactivityandbloodfeedingbymosquitoes AT gabrielaanine dehydrationpromptsincreasedactivityandbloodfeedingbymosquitoes AT paulalperez dehydrationpromptsincreasedactivityandbloodfeedingbymosquitoes AT alexandreerizlallah dehydrationpromptsincreasedactivityandbloodfeedingbymosquitoes AT mikiwatanabe dehydrationpromptsincreasedactivityandbloodfeedingbymosquitoes AT lindseyeromickrosendale dehydrationpromptsincreasedactivityandbloodfeedingbymosquitoes AT yanyuxiao dehydrationpromptsincreasedactivityandbloodfeedingbymosquitoes AT jasonlrasgon dehydrationpromptsincreasedactivityandbloodfeedingbymosquitoes AT joshuabbenoit dehydrationpromptsincreasedactivityandbloodfeedingbymosquitoes
_version_	1718388290705424384

Dehydration prompts increased activity and blood feeding by mosquitoes

Ejemplares similares