Effects of pre-pregnancy body mass index on pregnancy and perinatal outcomes in women based on a retrospective cohort

Abstract To investigate the prevalence of underweight, overweight and obesity as defined by pre-pregnancy body mass index (BMI) and the relationship between pre-pregnancy BMI and pregnancy and perinatal outcomes in women based on a retrospective cohort. Women registered via the Free Pre-pregnancy He...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Donghua Xie, Wenzhen Yang, Aihua Wang, Lili Xiong, Fanjuan Kong, Zhiyu Liu, Zhiqun Xie, Hua Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ef91febedaea4e508f64b9e691468f40
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ef91febedaea4e508f64b9e691468f40
record_format	dspace
spelling	oai:doaj.org-article:ef91febedaea4e508f64b9e691468f402021-12-02T19:16:19ZEffects of pre-pregnancy body mass index on pregnancy and perinatal outcomes in women based on a retrospective cohort10.1038/s41598-021-98892-y2045-2322https://doaj.org/article/ef91febedaea4e508f64b9e691468f402021-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98892-yhttps://doaj.org/toc/2045-2322Abstract To investigate the prevalence of underweight, overweight and obesity as defined by pre-pregnancy body mass index (BMI) and the relationship between pre-pregnancy BMI and pregnancy and perinatal outcomes in women based on a retrospective cohort. Women registered via the Free Pre-pregnancy Health Check (FPHC) program from 2017 to 2019 in Hunan Province, China, were included to the study cohort. The data regarding maternal characteristics, pregnancy outcomes, and infant characteristics were retrieved from the surveillance system of the FPHC program. Logistic regressions were performed to calculate odds ratios (ORs) and adjusted odds ratios (AORs) with 95% confidence intervals (95% CIs) to assess the associations between pre-pregnancy BMIs and the outcomes. Among a total of 398,368 women, 54,238 (13.62%) were underweight (BMI < 18.5 kg/m2), 51,251 (12.87%) were overweight (24.0 kg/m2 ≤ BMI < 28.0 kg/m2), and 10,399 (2.61%) were obese (BMI ≥ 28.0 kg/m2). Underweight occurred more commonly in the 20–24 years old (17.98%), Han Chinese (13.89), college-educated (16.09%), rural (13.74%), and teacher/public servant/office clerk (16.09%) groups. Obesity occurred more often in the older than 35-year-old (4.48%), minority (3.64%), primary school or below (4.98%), urban (3.06%), and housewife (3.14%) groups (P < 0.001). Compared with the normal BMI group, underweight was associated with increased risk of low birth weight (LBW) (AOR = 1.25) and small-for-gestational age (SGA) (AOR = 1.11), but protected against gestational hypertensive disorder (GHD) (AOR = 0.85), gestational diabetes mellitus (GDM) (AOR = 0.69), macrosomia (AOR = 0.67), post-term pregnancy (AOR = 0.76), and cesarean-section (AOR = 0.81). Overweight and obesity were associated with increased risk of GHD (AOR = 1.28, 2.47), GDM (AOR = 1.63, 3.02), preterm birth (AOR = 1.18, 1.47), macrosomia (AOR = 1.51, 2.11), large-for-gestational age (LGA) (AOR = 1.19, 1.35), post-term pregnancy (AOR = 1.39, 1.66), and cesarean- section (AOR = 1.60, 2.05). Pre-pregnancy underweight is relatively common in Hunan Province, China. Pre-pregnancy underweight to some extent is associated with better maternal outcomes, but it has certain adverse effects on neonatal outcomes. Pre-pregnancy overweight, especially obesity, has a substantial adverse effect on pregnancy and perinatal outcomes.Donghua XieWenzhen YangAihua WangLili XiongFanjuan KongZhiyu LiuZhiqun XieHua WangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Donghua Xie Wenzhen Yang Aihua Wang Lili Xiong Fanjuan Kong Zhiyu Liu Zhiqun Xie Hua Wang Effects of pre-pregnancy body mass index on pregnancy and perinatal outcomes in women based on a retrospective cohort
description	Abstract To investigate the prevalence of underweight, overweight and obesity as defined by pre-pregnancy body mass index (BMI) and the relationship between pre-pregnancy BMI and pregnancy and perinatal outcomes in women based on a retrospective cohort. Women registered via the Free Pre-pregnancy Health Check (FPHC) program from 2017 to 2019 in Hunan Province, China, were included to the study cohort. The data regarding maternal characteristics, pregnancy outcomes, and infant characteristics were retrieved from the surveillance system of the FPHC program. Logistic regressions were performed to calculate odds ratios (ORs) and adjusted odds ratios (AORs) with 95% confidence intervals (95% CIs) to assess the associations between pre-pregnancy BMIs and the outcomes. Among a total of 398,368 women, 54,238 (13.62%) were underweight (BMI < 18.5 kg/m2), 51,251 (12.87%) were overweight (24.0 kg/m2 ≤ BMI < 28.0 kg/m2), and 10,399 (2.61%) were obese (BMI ≥ 28.0 kg/m2). Underweight occurred more commonly in the 20–24 years old (17.98%), Han Chinese (13.89), college-educated (16.09%), rural (13.74%), and teacher/public servant/office clerk (16.09%) groups. Obesity occurred more often in the older than 35-year-old (4.48%), minority (3.64%), primary school or below (4.98%), urban (3.06%), and housewife (3.14%) groups (P < 0.001). Compared with the normal BMI group, underweight was associated with increased risk of low birth weight (LBW) (AOR = 1.25) and small-for-gestational age (SGA) (AOR = 1.11), but protected against gestational hypertensive disorder (GHD) (AOR = 0.85), gestational diabetes mellitus (GDM) (AOR = 0.69), macrosomia (AOR = 0.67), post-term pregnancy (AOR = 0.76), and cesarean-section (AOR = 0.81). Overweight and obesity were associated with increased risk of GHD (AOR = 1.28, 2.47), GDM (AOR = 1.63, 3.02), preterm birth (AOR = 1.18, 1.47), macrosomia (AOR = 1.51, 2.11), large-for-gestational age (LGA) (AOR = 1.19, 1.35), post-term pregnancy (AOR = 1.39, 1.66), and cesarean- section (AOR = 1.60, 2.05). Pre-pregnancy underweight is relatively common in Hunan Province, China. Pre-pregnancy underweight to some extent is associated with better maternal outcomes, but it has certain adverse effects on neonatal outcomes. Pre-pregnancy overweight, especially obesity, has a substantial adverse effect on pregnancy and perinatal outcomes.
format	article
author	Donghua Xie Wenzhen Yang Aihua Wang Lili Xiong Fanjuan Kong Zhiyu Liu Zhiqun Xie Hua Wang
author_facet	Donghua Xie Wenzhen Yang Aihua Wang Lili Xiong Fanjuan Kong Zhiyu Liu Zhiqun Xie Hua Wang
author_sort	Donghua Xie
title	Effects of pre-pregnancy body mass index on pregnancy and perinatal outcomes in women based on a retrospective cohort
title_short	Effects of pre-pregnancy body mass index on pregnancy and perinatal outcomes in women based on a retrospective cohort
title_full	Effects of pre-pregnancy body mass index on pregnancy and perinatal outcomes in women based on a retrospective cohort
title_fullStr	Effects of pre-pregnancy body mass index on pregnancy and perinatal outcomes in women based on a retrospective cohort
title_full_unstemmed	Effects of pre-pregnancy body mass index on pregnancy and perinatal outcomes in women based on a retrospective cohort
title_sort	effects of pre-pregnancy body mass index on pregnancy and perinatal outcomes in women based on a retrospective cohort
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ef91febedaea4e508f64b9e691468f40
work_keys_str_mv	AT donghuaxie effectsofprepregnancybodymassindexonpregnancyandperinataloutcomesinwomenbasedonaretrospectivecohort AT wenzhenyang effectsofprepregnancybodymassindexonpregnancyandperinataloutcomesinwomenbasedonaretrospectivecohort AT aihuawang effectsofprepregnancybodymassindexonpregnancyandperinataloutcomesinwomenbasedonaretrospectivecohort AT lilixiong effectsofprepregnancybodymassindexonpregnancyandperinataloutcomesinwomenbasedonaretrospectivecohort AT fanjuankong effectsofprepregnancybodymassindexonpregnancyandperinataloutcomesinwomenbasedonaretrospectivecohort AT zhiyuliu effectsofprepregnancybodymassindexonpregnancyandperinataloutcomesinwomenbasedonaretrospectivecohort AT zhiqunxie effectsofprepregnancybodymassindexonpregnancyandperinataloutcomesinwomenbasedonaretrospectivecohort AT huawang effectsofprepregnancybodymassindexonpregnancyandperinataloutcomesinwomenbasedonaretrospectivecohort
_version_	1718377005935755264

Effects of pre-pregnancy body mass index on pregnancy and perinatal outcomes in women based on a retrospective cohort

Ejemplares similares