Boosting functionality of synthetic DNA circuits with tailored deactivation

Nonlinearity in synthetic molecular circuits is usually achieved by manipulation of network topology or of production kinetics. Here, the authors achieve bistability and other nonlinear behaviours by manipulating the individual degradation rate laws of circuit components using saturable pathways.

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Detalles Bibliográficos
Autores principales: Kevin Montagne, Guillaume Gines, Teruo Fujii, Yannick Rondelez
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/ef972807c48a42ea878801ff6c0110c9
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Descripción
Sumario:Nonlinearity in synthetic molecular circuits is usually achieved by manipulation of network topology or of production kinetics. Here, the authors achieve bistability and other nonlinear behaviours by manipulating the individual degradation rate laws of circuit components using saturable pathways.