Negative 18F-FET PET/CT in brain metastasis recurrence: a teaching case report

Abstract Positron emission tomography (PET) using O-(2-[18F]fluoroethyl)-L-tyrosine (18F-FET) PET has been shown to be a useful tool for differentiating radiation therapy outcomes, such as brain metastasis recurrence or radiation necrosis. We present the case of a female patient with brain metastase...

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Autores principales:	Samirah Alshehri, John Prior, Mohammed Moshebah, Luis Schiappacasse, Vincent Dunet
Formato:	article
Lenguaje:	EN
Publicado:	SpringerOpen 2021
Materias:	Radiation Necrosis Brain Metastasis Medical physics. Medical radiology. Nuclear medicine R895-920
Acceso en línea:	https://doaj.org/article/ef9868e2e8fe49a0a5bc78d664ad469a
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spelling	oai:doaj.org-article:ef9868e2e8fe49a0a5bc78d664ad469a2021-11-28T12:25:26ZNegative 18F-FET PET/CT in brain metastasis recurrence: a teaching case report10.1186/s41824-021-00115-02510-3636https://doaj.org/article/ef9868e2e8fe49a0a5bc78d664ad469a2021-11-01T00:00:00Zhttps://doi.org/10.1186/s41824-021-00115-0https://doaj.org/toc/2510-3636Abstract Positron emission tomography (PET) using O-(2-[18F]fluoroethyl)-L-tyrosine (18F-FET) PET has been shown to be a useful tool for differentiating radiation therapy outcomes, such as brain metastasis recurrence or radiation necrosis. We present the case of a female patient with brain metastases from pulmonary mucinous adenocarcinoma with suspicion of tumor recurrence on follow-up magnetic resonance imaging (MRI) after radiosurgery. 18F-FET PET/computed tomography (CT) was indicative of radiation necrosis. Due to the patient's medical history and the discrepancy between the brain MRI and PET/CT results, surgical biopsies were decided, which were positive for brain metastasis recurrence. The diagnosis of metastasis recurrence may also be challenging on 18F-FET PET/CT. In case of discrepancies between MRI and PET/CT results, false-negative 18F-FET PET/CT remains a possibility and requires careful follow-up or biopsy.Samirah AlshehriJohn PriorMohammed MoshebahLuis SchiappacasseVincent DunetSpringerOpenarticleRadiationNecrosisBrainMetastasisMedical physics. Medical radiology. Nuclear medicineR895-920ENEuropean Journal of Hybrid Imaging, Vol 5, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Radiation Necrosis Brain Metastasis Medical physics. Medical radiology. Nuclear medicine R895-920
spellingShingle	Radiation Necrosis Brain Metastasis Medical physics. Medical radiology. Nuclear medicine R895-920 Samirah Alshehri John Prior Mohammed Moshebah Luis Schiappacasse Vincent Dunet Negative 18F-FET PET/CT in brain metastasis recurrence: a teaching case report
description	Abstract Positron emission tomography (PET) using O-(2-[18F]fluoroethyl)-L-tyrosine (18F-FET) PET has been shown to be a useful tool for differentiating radiation therapy outcomes, such as brain metastasis recurrence or radiation necrosis. We present the case of a female patient with brain metastases from pulmonary mucinous adenocarcinoma with suspicion of tumor recurrence on follow-up magnetic resonance imaging (MRI) after radiosurgery. 18F-FET PET/computed tomography (CT) was indicative of radiation necrosis. Due to the patient's medical history and the discrepancy between the brain MRI and PET/CT results, surgical biopsies were decided, which were positive for brain metastasis recurrence. The diagnosis of metastasis recurrence may also be challenging on 18F-FET PET/CT. In case of discrepancies between MRI and PET/CT results, false-negative 18F-FET PET/CT remains a possibility and requires careful follow-up or biopsy.
format	article
author	Samirah Alshehri John Prior Mohammed Moshebah Luis Schiappacasse Vincent Dunet
author_facet	Samirah Alshehri John Prior Mohammed Moshebah Luis Schiappacasse Vincent Dunet
author_sort	Samirah Alshehri
title	Negative 18F-FET PET/CT in brain metastasis recurrence: a teaching case report
title_short	Negative 18F-FET PET/CT in brain metastasis recurrence: a teaching case report
title_full	Negative 18F-FET PET/CT in brain metastasis recurrence: a teaching case report
title_fullStr	Negative 18F-FET PET/CT in brain metastasis recurrence: a teaching case report
title_full_unstemmed	Negative 18F-FET PET/CT in brain metastasis recurrence: a teaching case report
title_sort	negative 18f-fet pet/ct in brain metastasis recurrence: a teaching case report
publisher	SpringerOpen
publishDate	2021
url	https://doaj.org/article/ef9868e2e8fe49a0a5bc78d664ad469a
work_keys_str_mv	AT samirahalshehri negative18ffetpetctinbrainmetastasisrecurrenceateachingcasereport AT johnprior negative18ffetpetctinbrainmetastasisrecurrenceateachingcasereport AT mohammedmoshebah negative18ffetpetctinbrainmetastasisrecurrenceateachingcasereport AT luisschiappacasse negative18ffetpetctinbrainmetastasisrecurrenceateachingcasereport AT vincentdunet negative18ffetpetctinbrainmetastasisrecurrenceateachingcasereport
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Negative 18F-FET PET/CT in brain metastasis recurrence: a teaching case report

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