How peptic ulcer disease could potentially lead to the lifelong, debilitating effects of chronic fatigue syndrome: an insight

Abstract Chronic Fatigue Syndrome (CFS) has been defined as unexplained relapsing or persistent fatigue for at least 6 consecutive months. Immuno-inflammatory pathway, bacterial infection, and other causes play essential roles in CFS. Helicobacter pylori infection is one of the most common causes of...

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Autores principales:	Chien-Feng Kuo, Leiyu Shi, Cheng-Li Lin, Wei-Cheng Yao, Hsiang-Ting Chen, Chon-Fu Lio, Yu-Ting Tina Wang, Ching-Huang Su, Nai-Wei Hsu, Shin-Yi Tsai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ef9ed67f08de474c9e4fec612b7bd57b
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spelling	oai:doaj.org-article:ef9ed67f08de474c9e4fec612b7bd57b2021-12-02T14:17:19ZHow peptic ulcer disease could potentially lead to the lifelong, debilitating effects of chronic fatigue syndrome: an insight10.1038/s41598-021-87018-z2045-2322https://doaj.org/article/ef9ed67f08de474c9e4fec612b7bd57b2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87018-zhttps://doaj.org/toc/2045-2322Abstract Chronic Fatigue Syndrome (CFS) has been defined as unexplained relapsing or persistent fatigue for at least 6 consecutive months. Immuno-inflammatory pathway, bacterial infection, and other causes play essential roles in CFS. Helicobacter pylori infection is one of the most common causes of foregut inflammation, leading to peptic ulcer disease (PUD). This study aimed to analyze the risk of CFS development between patients with and without PUD. Other related factors were also analyzed. We performed a retrospective, nationwide cohort study identifying patients with or without PUD respectively by analyzing the Longitudinal Health Insurance Database 2000 (LHID2000), Taiwan. The overall incidence of CFS was higher in the PUD cohort than in the non- PUD cohort (HR = 2.01, 95% CI = 1.75–2.30), with the same adjusted HR (aHR) when adjusting for age, sex, and comorbidities. The sex-specific PUD cohort to the non-PUD cohort relative risk of CFS was significant in both genders. The age-specific incidence of CFS showed incidence density increasing with age in both cohorts. There is an increased risk of developing CFS following PUD, especially in females and the aging population. Hopefully, these findings can prevent common infections from progressing to debilitating, chronic conditions such as CFS.Chien-Feng KuoLeiyu ShiCheng-Li LinWei-Cheng YaoHsiang-Ting ChenChon-Fu LioYu-Ting Tina WangChing-Huang SuNai-Wei HsuShin-Yi TsaiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Chien-Feng Kuo Leiyu Shi Cheng-Li Lin Wei-Cheng Yao Hsiang-Ting Chen Chon-Fu Lio Yu-Ting Tina Wang Ching-Huang Su Nai-Wei Hsu Shin-Yi Tsai How peptic ulcer disease could potentially lead to the lifelong, debilitating effects of chronic fatigue syndrome: an insight
description	Abstract Chronic Fatigue Syndrome (CFS) has been defined as unexplained relapsing or persistent fatigue for at least 6 consecutive months. Immuno-inflammatory pathway, bacterial infection, and other causes play essential roles in CFS. Helicobacter pylori infection is one of the most common causes of foregut inflammation, leading to peptic ulcer disease (PUD). This study aimed to analyze the risk of CFS development between patients with and without PUD. Other related factors were also analyzed. We performed a retrospective, nationwide cohort study identifying patients with or without PUD respectively by analyzing the Longitudinal Health Insurance Database 2000 (LHID2000), Taiwan. The overall incidence of CFS was higher in the PUD cohort than in the non- PUD cohort (HR = 2.01, 95% CI = 1.75–2.30), with the same adjusted HR (aHR) when adjusting for age, sex, and comorbidities. The sex-specific PUD cohort to the non-PUD cohort relative risk of CFS was significant in both genders. The age-specific incidence of CFS showed incidence density increasing with age in both cohorts. There is an increased risk of developing CFS following PUD, especially in females and the aging population. Hopefully, these findings can prevent common infections from progressing to debilitating, chronic conditions such as CFS.
format	article
author	Chien-Feng Kuo Leiyu Shi Cheng-Li Lin Wei-Cheng Yao Hsiang-Ting Chen Chon-Fu Lio Yu-Ting Tina Wang Ching-Huang Su Nai-Wei Hsu Shin-Yi Tsai
author_facet	Chien-Feng Kuo Leiyu Shi Cheng-Li Lin Wei-Cheng Yao Hsiang-Ting Chen Chon-Fu Lio Yu-Ting Tina Wang Ching-Huang Su Nai-Wei Hsu Shin-Yi Tsai
author_sort	Chien-Feng Kuo
title	How peptic ulcer disease could potentially lead to the lifelong, debilitating effects of chronic fatigue syndrome: an insight
title_short	How peptic ulcer disease could potentially lead to the lifelong, debilitating effects of chronic fatigue syndrome: an insight
title_full	How peptic ulcer disease could potentially lead to the lifelong, debilitating effects of chronic fatigue syndrome: an insight
title_fullStr	How peptic ulcer disease could potentially lead to the lifelong, debilitating effects of chronic fatigue syndrome: an insight
title_full_unstemmed	How peptic ulcer disease could potentially lead to the lifelong, debilitating effects of chronic fatigue syndrome: an insight
title_sort	how peptic ulcer disease could potentially lead to the lifelong, debilitating effects of chronic fatigue syndrome: an insight
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ef9ed67f08de474c9e4fec612b7bd57b
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How peptic ulcer disease could potentially lead to the lifelong, debilitating effects of chronic fatigue syndrome: an insight

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