CaMKII-mediated Beclin 1 phosphorylation regulates autophagy that promotes degradation of Id and neuroblastoma cell differentiation

CaMKII-mediated Beclin 1 phosphorylation regulates autophagy that promotes degradation of Id and neuroblastoma cell differentiation

Neuroblastoma cell differentiation is regulated by Id proteins. Here, the authors show that CaMKII-mediated phosphorylation of Beclin 1 can activate K63-linked ubiquitination and autophagic degradation of Id proteins uncovering a role for autophagy in cell differentiation.

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Detalles Bibliográficos
Autores principales: Xuan Li, Xiao-Qi Wu, Rong Deng, Dan-Dan Li, Jun Tang, Wen-Dan Chen, Jing-Hong Chen, Jiao Ji, Lin Jiao, Shan Jiang, Fen Yang, Gong-Kan Feng, Ravichandran Senthilkumar, Fei Yue, Hai-Liang Zhang, Rui-Yan Wu, Yan Yu, Xue-Lian Xu, Jia Mai, Zhi-Ling Li, Xiao-Dan Peng, Yun Huang, Xiang Huang, Ning-Fang Ma, Qian Tao, Yi-Xin Zeng, Xiao-Feng Zhu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Science
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Acceso en línea:https://doaj.org/article/efa154aa063f4ab3b297d24aa034cdbf
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Sumario:Neuroblastoma cell differentiation is regulated by Id proteins. Here, the authors show that CaMKII-mediated phosphorylation of Beclin 1 can activate K63-linked ubiquitination and autophagic degradation of Id proteins uncovering a role for autophagy in cell differentiation.

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