CaMKII-mediated Beclin 1 phosphorylation regulates autophagy that promotes degradation of Id and neuroblastoma cell differentiation

CaMKII-mediated Beclin 1 phosphorylation regulates autophagy that promotes degradation of Id and neuroblastoma cell differentiation

Neuroblastoma cell differentiation is regulated by Id proteins. Here, the authors show that CaMKII-mediated phosphorylation of Beclin 1 can activate K63-linked ubiquitination and autophagic degradation of Id proteins uncovering a role for autophagy in cell differentiation.

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Autores principales: Xuan Li, Xiao-Qi Wu, Rong Deng, Dan-Dan Li, Jun Tang, Wen-Dan Chen, Jing-Hong Chen, Jiao Ji, Lin Jiao, Shan Jiang, Fen Yang, Gong-Kan Feng, Ravichandran Senthilkumar, Fei Yue, Hai-Liang Zhang, Rui-Yan Wu, Yan Yu, Xue-Lian Xu, Jia Mai, Zhi-Ling Li, Xiao-Dan Peng, Yun Huang, Xiang Huang, Ning-Fang Ma, Qian Tao, Yi-Xin Zeng, Xiao-Feng Zhu
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Lenguaje:EN
Publicado: Nature Portfolio 2017
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spelling oai:doaj.org-article:efa154aa063f4ab3b297d24aa034cdbf2021-12-02T14:41:59ZCaMKII-mediated Beclin 1 phosphorylation regulates autophagy that promotes degradation of Id and neuroblastoma cell differentiation10.1038/s41467-017-01272-22041-1723https://doaj.org/article/efa154aa063f4ab3b297d24aa034cdbf2017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01272-2https://doaj.org/toc/2041-1723Neuroblastoma cell differentiation is regulated by Id proteins. Here, the authors show that CaMKII-mediated phosphorylation of Beclin 1 can activate K63-linked ubiquitination and autophagic degradation of Id proteins uncovering a role for autophagy in cell differentiation.Xuan LiXiao-Qi WuRong DengDan-Dan LiJun TangWen-Dan ChenJing-Hong ChenJiao JiLin JiaoShan JiangFen YangGong-Kan FengRavichandran SenthilkumarFei YueHai-Liang ZhangRui-Yan WuYan YuXue-Lian XuJia MaiZhi-Ling LiXiao-Dan PengYun HuangXiang HuangNing-Fang MaQian TaoYi-Xin ZengXiao-Feng ZhuNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Xuan Li
Xiao-Qi Wu
Rong Deng
Dan-Dan Li
Jun Tang
Wen-Dan Chen
Jing-Hong Chen
Jiao Ji
Lin Jiao
Shan Jiang
Fen Yang
Gong-Kan Feng
Ravichandran Senthilkumar
Fei Yue
Hai-Liang Zhang
Rui-Yan Wu
Yan Yu
Xue-Lian Xu
Jia Mai
Zhi-Ling Li
Xiao-Dan Peng
Yun Huang
Xiang Huang
Ning-Fang Ma
Qian Tao
Yi-Xin Zeng
Xiao-Feng Zhu
CaMKII-mediated Beclin 1 phosphorylation regulates autophagy that promotes degradation of Id and neuroblastoma cell differentiation
description Neuroblastoma cell differentiation is regulated by Id proteins. Here, the authors show that CaMKII-mediated phosphorylation of Beclin 1 can activate K63-linked ubiquitination and autophagic degradation of Id proteins uncovering a role for autophagy in cell differentiation.
format article
author Xuan Li
Xiao-Qi Wu
Rong Deng
Dan-Dan Li
Jun Tang
Wen-Dan Chen
Jing-Hong Chen
Jiao Ji
Lin Jiao
Shan Jiang
Fen Yang
Gong-Kan Feng
Ravichandran Senthilkumar
Fei Yue
Hai-Liang Zhang
Rui-Yan Wu
Yan Yu
Xue-Lian Xu
Jia Mai
Zhi-Ling Li
Xiao-Dan Peng
Yun Huang
Xiang Huang
Ning-Fang Ma
Qian Tao
Yi-Xin Zeng
Xiao-Feng Zhu
author_facet Xuan Li
Xiao-Qi Wu
Rong Deng
Dan-Dan Li
Jun Tang
Wen-Dan Chen
Jing-Hong Chen
Jiao Ji
Lin Jiao
Shan Jiang
Fen Yang
Gong-Kan Feng
Ravichandran Senthilkumar
Fei Yue
Hai-Liang Zhang
Rui-Yan Wu
Yan Yu
Xue-Lian Xu
Jia Mai
Zhi-Ling Li
Xiao-Dan Peng
Yun Huang
Xiang Huang
Ning-Fang Ma
Qian Tao
Yi-Xin Zeng
Xiao-Feng Zhu
author_sort Xuan Li
title CaMKII-mediated Beclin 1 phosphorylation regulates autophagy that promotes degradation of Id and neuroblastoma cell differentiation
title_short CaMKII-mediated Beclin 1 phosphorylation regulates autophagy that promotes degradation of Id and neuroblastoma cell differentiation
title_full CaMKII-mediated Beclin 1 phosphorylation regulates autophagy that promotes degradation of Id and neuroblastoma cell differentiation
title_fullStr CaMKII-mediated Beclin 1 phosphorylation regulates autophagy that promotes degradation of Id and neuroblastoma cell differentiation
title_full_unstemmed CaMKII-mediated Beclin 1 phosphorylation regulates autophagy that promotes degradation of Id and neuroblastoma cell differentiation
title_sort camkii-mediated beclin 1 phosphorylation regulates autophagy that promotes degradation of id and neuroblastoma cell differentiation
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/efa154aa063f4ab3b297d24aa034cdbf
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