Monoallelic expression and epigenetic inheritance sustained by a Trypanosoma brucei variant surface glycoprotein exclusion complex

Monoallelic expression of variant surface glycoprotein genes (VSGs) is essential for immune evasion by Trypanosoma brucei. Here, Faria et al. show that the VEX protein complex controls VSG allelic exclusion, and that CAF‐1 sustains inheritance of the VEX‐complex in association with the active VSG....

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Autores principales:	Joana Faria, Lucy Glover, Sebastian Hutchinson, Cordula Boehm, Mark C. Field, David Horn
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/efa215bb5b8341a084cb1cc4eee142c9
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spelling	oai:doaj.org-article:efa215bb5b8341a084cb1cc4eee142c92021-12-02T17:33:11ZMonoallelic expression and epigenetic inheritance sustained by a Trypanosoma brucei variant surface glycoprotein exclusion complex10.1038/s41467-019-10823-82041-1723https://doaj.org/article/efa215bb5b8341a084cb1cc4eee142c92019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10823-8https://doaj.org/toc/2041-1723Monoallelic expression of variant surface glycoprotein genes (VSGs) is essential for immune evasion by Trypanosoma brucei. Here, Faria et al. show that the VEX protein complex controls VSG allelic exclusion, and that CAF‐1 sustains inheritance of the VEX‐complex in association with the active VSG.Joana FariaLucy GloverSebastian HutchinsonCordula BoehmMark C. FieldDavid HornNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Joana Faria Lucy Glover Sebastian Hutchinson Cordula Boehm Mark C. Field David Horn Monoallelic expression and epigenetic inheritance sustained by a Trypanosoma brucei variant surface glycoprotein exclusion complex
description	Monoallelic expression of variant surface glycoprotein genes (VSGs) is essential for immune evasion by Trypanosoma brucei. Here, Faria et al. show that the VEX protein complex controls VSG allelic exclusion, and that CAF‐1 sustains inheritance of the VEX‐complex in association with the active VSG.
format	article
author	Joana Faria Lucy Glover Sebastian Hutchinson Cordula Boehm Mark C. Field David Horn
author_facet	Joana Faria Lucy Glover Sebastian Hutchinson Cordula Boehm Mark C. Field David Horn
author_sort	Joana Faria
title	Monoallelic expression and epigenetic inheritance sustained by a Trypanosoma brucei variant surface glycoprotein exclusion complex
title_short	Monoallelic expression and epigenetic inheritance sustained by a Trypanosoma brucei variant surface glycoprotein exclusion complex
title_full	Monoallelic expression and epigenetic inheritance sustained by a Trypanosoma brucei variant surface glycoprotein exclusion complex
title_fullStr	Monoallelic expression and epigenetic inheritance sustained by a Trypanosoma brucei variant surface glycoprotein exclusion complex
title_full_unstemmed	Monoallelic expression and epigenetic inheritance sustained by a Trypanosoma brucei variant surface glycoprotein exclusion complex
title_sort	monoallelic expression and epigenetic inheritance sustained by a trypanosoma brucei variant surface glycoprotein exclusion complex
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/efa215bb5b8341a084cb1cc4eee142c9
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Monoallelic expression and epigenetic inheritance sustained by a Trypanosoma brucei variant surface glycoprotein exclusion complex

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