Progress on RNAi-based molecular medicines

Progress on RNAi-based molecular medicines

Jing Chen, Jianping XieInstitute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Ministry of Education Eco-Environment of the Three Gorges Reservoir Region, School of Life Sciences, Southwest University, Chongqing, ChinaAbstract: RNA interference (RNAi) is a promising strategy to...

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Autores principales: Chen J, Xie JP
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2012
Materias:
Medicine (General)
R5-920
Acceso en línea:https://doaj.org/article/efa2847a5351490ab47f15dfe5f76028
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spelling oai:doaj.org-article:efa2847a5351490ab47f15dfe5f760282021-12-02T02:49:27ZProgress on RNAi-based molecular medicines1176-91141178-2013https://doaj.org/article/efa2847a5351490ab47f15dfe5f760282012-07-01T00:00:00Zhttp://www.dovepress.com/progress-on-rnai-based-molecular-medicines-a10518https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Jing Chen, Jianping XieInstitute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Ministry of Education Eco-Environment of the Three Gorges Reservoir Region, School of Life Sciences, Southwest University, Chongqing, ChinaAbstract: RNA interference (RNAi) is a promising strategy to suppress the expression of disease-relevant genes and induce post-transcriptional gene silencing. Their simplicity and stability endow RNAi with great advantages in molecular medicine. Several RNAi-based drugs are in various stages of clinical investigation. This review summarizes the ongoing research endeavors on RNAi in molecular medicine, delivery systems for RNAi-based drugs, and a compendium of RNAi drugs in different stages of clinical development. Of special interest are RNAi-based drug target discovery and validation, delivery systems for RNAi-based drugs, such as nanoparticles, rabies virus protein-based vehicles, and bacteriophages for RNA packaging.Keywords: RNA interference, delivery systems, liposome, nanoparticle, molecular medicinesChen JXie JPDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2012, Iss default, Pp 3971-3980 (2012)
institution DOAJ
collection DOAJ
language EN
topic Medicine (General)
R5-920
spellingShingle Medicine (General)
R5-920
Chen J
Xie JP
Progress on RNAi-based molecular medicines
description Jing Chen, Jianping XieInstitute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Ministry of Education Eco-Environment of the Three Gorges Reservoir Region, School of Life Sciences, Southwest University, Chongqing, ChinaAbstract: RNA interference (RNAi) is a promising strategy to suppress the expression of disease-relevant genes and induce post-transcriptional gene silencing. Their simplicity and stability endow RNAi with great advantages in molecular medicine. Several RNAi-based drugs are in various stages of clinical investigation. This review summarizes the ongoing research endeavors on RNAi in molecular medicine, delivery systems for RNAi-based drugs, and a compendium of RNAi drugs in different stages of clinical development. Of special interest are RNAi-based drug target discovery and validation, delivery systems for RNAi-based drugs, such as nanoparticles, rabies virus protein-based vehicles, and bacteriophages for RNA packaging.Keywords: RNA interference, delivery systems, liposome, nanoparticle, molecular medicines
format article
author Chen J
Xie JP
author_facet Chen J
Xie JP
author_sort Chen J
title Progress on RNAi-based molecular medicines
title_short Progress on RNAi-based molecular medicines
title_full Progress on RNAi-based molecular medicines
title_fullStr Progress on RNAi-based molecular medicines
title_full_unstemmed Progress on RNAi-based molecular medicines
title_sort progress on rnai-based molecular medicines
publisher Dove Medical Press
publishDate 2012
url https://doaj.org/article/efa2847a5351490ab47f15dfe5f76028
work_keys_str_mv AT chenj progressonrnaibasedmolecularmedicines
AT xiejp progressonrnaibasedmolecularmedicines
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