EZH1 and EZH2 promote skeletal growth by repressing inhibitors of chondrocyte proliferation and hypertrophy

EZH1 and EZH2 are associated with epigenetic bone and cartilage developmental defects. Here the authors show that cartilage-specific double knockout mice have reduced skeletal growth and how these histone methyltransferases regulate chondrogenesis and endochondral bone development.

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Autores principales:	Julian C. Lui, Presley Garrison, Quang Nguyen, Michal Ad, Chithra Keembiyehetty, Weiping Chen, Youn Hee Jee, Ellie Landman, Ola Nilsson, Kevin M. Barnes, Jeffrey Baron
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/efa3d063166f4765ab0158eaae143a1b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:efa3d063166f4765ab0158eaae143a1b2021-12-02T17:32:36ZEZH1 and EZH2 promote skeletal growth by repressing inhibitors of chondrocyte proliferation and hypertrophy10.1038/ncomms136852041-1723https://doaj.org/article/efa3d063166f4765ab0158eaae143a1b2016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13685https://doaj.org/toc/2041-1723EZH1 and EZH2 are associated with epigenetic bone and cartilage developmental defects. Here the authors show that cartilage-specific double knockout mice have reduced skeletal growth and how these histone methyltransferases regulate chondrogenesis and endochondral bone development.Julian C. LuiPresley GarrisonQuang NguyenMichal AdChithra KeembiyehettyWeiping ChenYoun Hee JeeEllie LandmanOla NilssonKevin M. BarnesJeffrey BaronNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Julian C. Lui Presley Garrison Quang Nguyen Michal Ad Chithra Keembiyehetty Weiping Chen Youn Hee Jee Ellie Landman Ola Nilsson Kevin M. Barnes Jeffrey Baron EZH1 and EZH2 promote skeletal growth by repressing inhibitors of chondrocyte proliferation and hypertrophy
description	EZH1 and EZH2 are associated with epigenetic bone and cartilage developmental defects. Here the authors show that cartilage-specific double knockout mice have reduced skeletal growth and how these histone methyltransferases regulate chondrogenesis and endochondral bone development.
format	article
author	Julian C. Lui Presley Garrison Quang Nguyen Michal Ad Chithra Keembiyehetty Weiping Chen Youn Hee Jee Ellie Landman Ola Nilsson Kevin M. Barnes Jeffrey Baron
author_facet	Julian C. Lui Presley Garrison Quang Nguyen Michal Ad Chithra Keembiyehetty Weiping Chen Youn Hee Jee Ellie Landman Ola Nilsson Kevin M. Barnes Jeffrey Baron
author_sort	Julian C. Lui
title	EZH1 and EZH2 promote skeletal growth by repressing inhibitors of chondrocyte proliferation and hypertrophy
title_short	EZH1 and EZH2 promote skeletal growth by repressing inhibitors of chondrocyte proliferation and hypertrophy
title_full	EZH1 and EZH2 promote skeletal growth by repressing inhibitors of chondrocyte proliferation and hypertrophy
title_fullStr	EZH1 and EZH2 promote skeletal growth by repressing inhibitors of chondrocyte proliferation and hypertrophy
title_full_unstemmed	EZH1 and EZH2 promote skeletal growth by repressing inhibitors of chondrocyte proliferation and hypertrophy
title_sort	ezh1 and ezh2 promote skeletal growth by repressing inhibitors of chondrocyte proliferation and hypertrophy
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/efa3d063166f4765ab0158eaae143a1b
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EZH1 and EZH2 promote skeletal growth by repressing inhibitors of chondrocyte proliferation and hypertrophy

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