Understanding Monoclonal B Cell Lymphocytosis: An Interplay of Genetic and Microenvironmental Factors

The term monoclonal B-cell lymphocytosis (MBL) describes the presence of a clonal B cell population with a count of less than 5 × 109/L and no symptoms or signs of disease. Based on the B cell count, MBL is further classified into 2 distinct subtypes: ‘low-count’ and ‘high-count’ MBL. High-count MBL...

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Autores principales:	Chrysi Galigalidou, Laura Zaragoza-Infante, Anastasia Iatrou, Anastasia Chatzidimitriou, Kostas Stamatopoulos, Andreas Agathangelidis
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	monoclonal B cell lymphocytosis (MBL) chronic Lymphocutic Leukemia (CLL) genetics immunogenetics tumor microenvironment ontogenesis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/efa67e0fa42246998d881be6f07618f4
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spelling	oai:doaj.org-article:efa67e0fa42246998d881be6f07618f42021-11-11T04:42:52ZUnderstanding Monoclonal B Cell Lymphocytosis: An Interplay of Genetic and Microenvironmental Factors2234-943X10.3389/fonc.2021.769612https://doaj.org/article/efa67e0fa42246998d881be6f07618f42021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.769612/fullhttps://doaj.org/toc/2234-943XThe term monoclonal B-cell lymphocytosis (MBL) describes the presence of a clonal B cell population with a count of less than 5 × 109/L and no symptoms or signs of disease. Based on the B cell count, MBL is further classified into 2 distinct subtypes: ‘low-count’ and ‘high-count’ MBL. High-count MBL shares a series of biological and clinical features with chronic lymphocytic leukemia (CLL), at least of the indolent type, and evolves to CLL requiring treatment at a rate of 1-2% per year, whereas ‘low-count’ MBL seems to be distinct, likely representing an immunological rather than a pre-malignant condition. That notwithstanding, both subtypes of MBL can carry ‘CLL-specific’ genomic aberrations such as cytogenetic abnormalities and gene mutations, yet to a much lesser extent compared to CLL. These findings suggest that such aberrations are mostly relevant for disease progression rather than disease onset, indirectly pointing to microenvironmental drive as a key contributor to the emergence of MBL. Understanding microenvironmental interactions is therefore anticipated to elucidate MBL ontogeny and, most importantly, the relationship between MBL and CLL.Chrysi GaligalidouChrysi GaligalidouLaura Zaragoza-InfanteLaura Zaragoza-InfanteAnastasia IatrouAnastasia ChatzidimitriouAnastasia ChatzidimitriouKostas StamatopoulosKostas StamatopoulosAndreas AgathangelidisAndreas AgathangelidisFrontiers Media S.A.articlemonoclonal B cell lymphocytosis (MBL)chronic Lymphocutic Leukemia (CLL)geneticsimmunogeneticstumor microenvironmentontogenesisNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	monoclonal B cell lymphocytosis (MBL) chronic Lymphocutic Leukemia (CLL) genetics immunogenetics tumor microenvironment ontogenesis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	monoclonal B cell lymphocytosis (MBL) chronic Lymphocutic Leukemia (CLL) genetics immunogenetics tumor microenvironment ontogenesis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Chrysi Galigalidou Chrysi Galigalidou Laura Zaragoza-Infante Laura Zaragoza-Infante Anastasia Iatrou Anastasia Chatzidimitriou Anastasia Chatzidimitriou Kostas Stamatopoulos Kostas Stamatopoulos Andreas Agathangelidis Andreas Agathangelidis Understanding Monoclonal B Cell Lymphocytosis: An Interplay of Genetic and Microenvironmental Factors
description	The term monoclonal B-cell lymphocytosis (MBL) describes the presence of a clonal B cell population with a count of less than 5 × 109/L and no symptoms or signs of disease. Based on the B cell count, MBL is further classified into 2 distinct subtypes: ‘low-count’ and ‘high-count’ MBL. High-count MBL shares a series of biological and clinical features with chronic lymphocytic leukemia (CLL), at least of the indolent type, and evolves to CLL requiring treatment at a rate of 1-2% per year, whereas ‘low-count’ MBL seems to be distinct, likely representing an immunological rather than a pre-malignant condition. That notwithstanding, both subtypes of MBL can carry ‘CLL-specific’ genomic aberrations such as cytogenetic abnormalities and gene mutations, yet to a much lesser extent compared to CLL. These findings suggest that such aberrations are mostly relevant for disease progression rather than disease onset, indirectly pointing to microenvironmental drive as a key contributor to the emergence of MBL. Understanding microenvironmental interactions is therefore anticipated to elucidate MBL ontogeny and, most importantly, the relationship between MBL and CLL.
format	article
author	Chrysi Galigalidou Chrysi Galigalidou Laura Zaragoza-Infante Laura Zaragoza-Infante Anastasia Iatrou Anastasia Chatzidimitriou Anastasia Chatzidimitriou Kostas Stamatopoulos Kostas Stamatopoulos Andreas Agathangelidis Andreas Agathangelidis
author_facet	Chrysi Galigalidou Chrysi Galigalidou Laura Zaragoza-Infante Laura Zaragoza-Infante Anastasia Iatrou Anastasia Chatzidimitriou Anastasia Chatzidimitriou Kostas Stamatopoulos Kostas Stamatopoulos Andreas Agathangelidis Andreas Agathangelidis
author_sort	Chrysi Galigalidou
title	Understanding Monoclonal B Cell Lymphocytosis: An Interplay of Genetic and Microenvironmental Factors
title_short	Understanding Monoclonal B Cell Lymphocytosis: An Interplay of Genetic and Microenvironmental Factors
title_full	Understanding Monoclonal B Cell Lymphocytosis: An Interplay of Genetic and Microenvironmental Factors
title_fullStr	Understanding Monoclonal B Cell Lymphocytosis: An Interplay of Genetic and Microenvironmental Factors
title_full_unstemmed	Understanding Monoclonal B Cell Lymphocytosis: An Interplay of Genetic and Microenvironmental Factors
title_sort	understanding monoclonal b cell lymphocytosis: an interplay of genetic and microenvironmental factors
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/efa67e0fa42246998d881be6f07618f4
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Understanding Monoclonal B Cell Lymphocytosis: An Interplay of Genetic and Microenvironmental Factors

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