Decrease with aging of the microcirculatory function of the lumbar vertebral marrow preceding the loss of bone material density and the onset of intervertebral discal degeneration: A study about the potential cause

Objective: Using a dynamic computed tomographic perfusion (CTP) imaging method to explore the age-related distribution of the microcirculation perfusion function in the vertebral marrow, the bone material density (BMD), and the intervertebral discal degeneration (IDD). Further, to discuss a possible...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Lin Ou-yang, Guang-ming Lu
Formato: article
Lenguaje:EN
Publicado: KeAi Communications Co., Ltd. 2015
Materias:
Acceso en línea:https://doaj.org/article/efa7880d029b43fe89d2337119ce065e
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:efa7880d029b43fe89d2337119ce065e
record_format dspace
spelling oai:doaj.org-article:efa7880d029b43fe89d2337119ce065e2021-12-02T10:50:49ZDecrease with aging of the microcirculatory function of the lumbar vertebral marrow preceding the loss of bone material density and the onset of intervertebral discal degeneration: A study about the potential cause2095-882X10.1016/j.cdtm.2015.02.007https://doaj.org/article/efa7880d029b43fe89d2337119ce065e2015-06-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2095882X15000080https://doaj.org/toc/2095-882XObjective: Using a dynamic computed tomographic perfusion (CTP) imaging method to explore the age-related distribution of the microcirculation perfusion function in the vertebral marrow, the bone material density (BMD), and the intervertebral discal degeneration (IDD). Further, to discuss a possible causation relationship between them. Methods: One hundred and eighty-six people were randomly enrolled by stratified sampling and grouped by age: â¤15, 16â25, 26â35, 36â45, 46â55, 56â65, 66â75, and â¥76 years old. The average CTP and BMD of the third and fourth lumbar vertebrae marrow were measured and the IDD incidence of the third-fourth vertebrae was assessed. The temporalâspatial distribution patterns of the age-related changes of the CTP, BMD, and IDD were described, and the correlations between them were calculated. Results: The microcirculatory perfusion function of the vertebral marrow develops to maturity by 25 years and is maintained until age 35, then declines with aging. The BMD grew to a peak from 26 to 45 years old, then decreased yearly. The IDD showed a sudden increase after 45 years of age. The CTP [BF (r = 0.806, P = 0.000), BV (r = 0.685, P = 0.005) and PMB (r = 0.619, P = 0.001)] showed strong positive correlations and CTP [TTP (r = â0.211, P = 0.322) and MTT (r = â0.598, P = 0.002)] showed negative correlations with BMD. The CTP [BF (r = â0.815, P = 0.000), BV (r = â0.753, P = 0.000) and PMB (r = â0.690, P = 0.000)] had strong negative correlations, and CTP [TTP (r = 0.323, P = 0.126) and MTT (r = 0.628, P = 0.001)] had positive correlations with the incidence of IDD. Conclusion: The decrease with aging of the microcirculatory perfusion in the lumbar vertebral marrow preceded, and is a potential causative factor for the loss of BMD and the onset of IDD. Keywords: Lumbar spinal degeneration, Microcirculatory function, Hemodynamics, CT perfusion (CTP)Lin Ou-yangGuang-ming LuKeAi Communications Co., Ltd.articleMedicine (General)R5-920ENChronic Diseases and Translational Medicine, Vol 1, Iss 2, Pp 96-104 (2015)
institution DOAJ
collection DOAJ
language EN
topic Medicine (General)
R5-920
spellingShingle Medicine (General)
R5-920
Lin Ou-yang
Guang-ming Lu
Decrease with aging of the microcirculatory function of the lumbar vertebral marrow preceding the loss of bone material density and the onset of intervertebral discal degeneration: A study about the potential cause
description Objective: Using a dynamic computed tomographic perfusion (CTP) imaging method to explore the age-related distribution of the microcirculation perfusion function in the vertebral marrow, the bone material density (BMD), and the intervertebral discal degeneration (IDD). Further, to discuss a possible causation relationship between them. Methods: One hundred and eighty-six people were randomly enrolled by stratified sampling and grouped by age: â¤15, 16â25, 26â35, 36â45, 46â55, 56â65, 66â75, and â¥76 years old. The average CTP and BMD of the third and fourth lumbar vertebrae marrow were measured and the IDD incidence of the third-fourth vertebrae was assessed. The temporalâspatial distribution patterns of the age-related changes of the CTP, BMD, and IDD were described, and the correlations between them were calculated. Results: The microcirculatory perfusion function of the vertebral marrow develops to maturity by 25 years and is maintained until age 35, then declines with aging. The BMD grew to a peak from 26 to 45 years old, then decreased yearly. The IDD showed a sudden increase after 45 years of age. The CTP [BF (r = 0.806, P = 0.000), BV (r = 0.685, P = 0.005) and PMB (r = 0.619, P = 0.001)] showed strong positive correlations and CTP [TTP (r = â0.211, P = 0.322) and MTT (r = â0.598, P = 0.002)] showed negative correlations with BMD. The CTP [BF (r = â0.815, P = 0.000), BV (r = â0.753, P = 0.000) and PMB (r = â0.690, P = 0.000)] had strong negative correlations, and CTP [TTP (r = 0.323, P = 0.126) and MTT (r = 0.628, P = 0.001)] had positive correlations with the incidence of IDD. Conclusion: The decrease with aging of the microcirculatory perfusion in the lumbar vertebral marrow preceded, and is a potential causative factor for the loss of BMD and the onset of IDD. Keywords: Lumbar spinal degeneration, Microcirculatory function, Hemodynamics, CT perfusion (CTP)
format article
author Lin Ou-yang
Guang-ming Lu
author_facet Lin Ou-yang
Guang-ming Lu
author_sort Lin Ou-yang
title Decrease with aging of the microcirculatory function of the lumbar vertebral marrow preceding the loss of bone material density and the onset of intervertebral discal degeneration: A study about the potential cause
title_short Decrease with aging of the microcirculatory function of the lumbar vertebral marrow preceding the loss of bone material density and the onset of intervertebral discal degeneration: A study about the potential cause
title_full Decrease with aging of the microcirculatory function of the lumbar vertebral marrow preceding the loss of bone material density and the onset of intervertebral discal degeneration: A study about the potential cause
title_fullStr Decrease with aging of the microcirculatory function of the lumbar vertebral marrow preceding the loss of bone material density and the onset of intervertebral discal degeneration: A study about the potential cause
title_full_unstemmed Decrease with aging of the microcirculatory function of the lumbar vertebral marrow preceding the loss of bone material density and the onset of intervertebral discal degeneration: A study about the potential cause
title_sort decrease with aging of the microcirculatory function of the lumbar vertebral marrow preceding the loss of bone material density and the onset of intervertebral discal degeneration: a study about the potential cause
publisher KeAi Communications Co., Ltd.
publishDate 2015
url https://doaj.org/article/efa7880d029b43fe89d2337119ce065e
work_keys_str_mv AT linouyang decreasewithagingofthemicrocirculatoryfunctionofthelumbarvertebralmarrowprecedingthelossofbonematerialdensityandtheonsetofintervertebraldiscaldegenerationastudyaboutthepotentialcause
AT guangminglu decreasewithagingofthemicrocirculatoryfunctionofthelumbarvertebralmarrowprecedingthelossofbonematerialdensityandtheonsetofintervertebraldiscaldegenerationastudyaboutthepotentialcause
_version_ 1718396563954335744