Generation of mesenchyme free intestinal organoids from human induced pluripotent stem cells

Human induced pluripotent stem cell-derived intestinal organoids (HIOs) are powerful tools to study development and diseases of the gastrointestinal tract. Here, the authors develop a directed differentiation protocol to generate mesenchyme-free HIOs that can be patterned towards proximal small inte...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Aditya Mithal, Amalia Capilla, Dar Heinze, Andrew Berical, Carlos Villacorta-Martin, Marall Vedaie, Anjali Jacob, Kristine Abo, Aleksander Szymaniak, Megan Peasley, Alexander Stuffer, John Mahoney, Darrell N. Kotton, Finn Hawkins, Gustavo Mostoslavsky
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/efa815c9f57c43c1a9355336f273c3c9
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:efa815c9f57c43c1a9355336f273c3c9
record_format	dspace
spelling	oai:doaj.org-article:efa815c9f57c43c1a9355336f273c3c92021-12-02T14:40:38ZGeneration of mesenchyme free intestinal organoids from human induced pluripotent stem cells10.1038/s41467-019-13916-62041-1723https://doaj.org/article/efa815c9f57c43c1a9355336f273c3c92020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13916-6https://doaj.org/toc/2041-1723Human induced pluripotent stem cell-derived intestinal organoids (HIOs) are powerful tools to study development and diseases of the gastrointestinal tract. Here, the authors develop a directed differentiation protocol to generate mesenchyme-free HIOs that can be patterned towards proximal small intestine or colonic epithelium, and demonstrated their utility in modeling CFTR function.Aditya MithalAmalia CapillaDar HeinzeAndrew BericalCarlos Villacorta-MartinMarall VedaieAnjali JacobKristine AboAleksander SzymaniakMegan PeasleyAlexander StufferJohn MahoneyDarrell N. KottonFinn HawkinsGustavo MostoslavskyNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Aditya Mithal Amalia Capilla Dar Heinze Andrew Berical Carlos Villacorta-Martin Marall Vedaie Anjali Jacob Kristine Abo Aleksander Szymaniak Megan Peasley Alexander Stuffer John Mahoney Darrell N. Kotton Finn Hawkins Gustavo Mostoslavsky Generation of mesenchyme free intestinal organoids from human induced pluripotent stem cells
description	Human induced pluripotent stem cell-derived intestinal organoids (HIOs) are powerful tools to study development and diseases of the gastrointestinal tract. Here, the authors develop a directed differentiation protocol to generate mesenchyme-free HIOs that can be patterned towards proximal small intestine or colonic epithelium, and demonstrated their utility in modeling CFTR function.
format	article
author	Aditya Mithal Amalia Capilla Dar Heinze Andrew Berical Carlos Villacorta-Martin Marall Vedaie Anjali Jacob Kristine Abo Aleksander Szymaniak Megan Peasley Alexander Stuffer John Mahoney Darrell N. Kotton Finn Hawkins Gustavo Mostoslavsky
author_facet	Aditya Mithal Amalia Capilla Dar Heinze Andrew Berical Carlos Villacorta-Martin Marall Vedaie Anjali Jacob Kristine Abo Aleksander Szymaniak Megan Peasley Alexander Stuffer John Mahoney Darrell N. Kotton Finn Hawkins Gustavo Mostoslavsky
author_sort	Aditya Mithal
title	Generation of mesenchyme free intestinal organoids from human induced pluripotent stem cells
title_short	Generation of mesenchyme free intestinal organoids from human induced pluripotent stem cells
title_full	Generation of mesenchyme free intestinal organoids from human induced pluripotent stem cells
title_fullStr	Generation of mesenchyme free intestinal organoids from human induced pluripotent stem cells
title_full_unstemmed	Generation of mesenchyme free intestinal organoids from human induced pluripotent stem cells
title_sort	generation of mesenchyme free intestinal organoids from human induced pluripotent stem cells
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/efa815c9f57c43c1a9355336f273c3c9
work_keys_str_mv	AT adityamithal generationofmesenchymefreeintestinalorganoidsfromhumaninducedpluripotentstemcells AT amaliacapilla generationofmesenchymefreeintestinalorganoidsfromhumaninducedpluripotentstemcells AT darheinze generationofmesenchymefreeintestinalorganoidsfromhumaninducedpluripotentstemcells AT andrewberical generationofmesenchymefreeintestinalorganoidsfromhumaninducedpluripotentstemcells AT carlosvillacortamartin generationofmesenchymefreeintestinalorganoidsfromhumaninducedpluripotentstemcells AT marallvedaie generationofmesenchymefreeintestinalorganoidsfromhumaninducedpluripotentstemcells AT anjalijacob generationofmesenchymefreeintestinalorganoidsfromhumaninducedpluripotentstemcells AT kristineabo generationofmesenchymefreeintestinalorganoidsfromhumaninducedpluripotentstemcells AT aleksanderszymaniak generationofmesenchymefreeintestinalorganoidsfromhumaninducedpluripotentstemcells AT meganpeasley generationofmesenchymefreeintestinalorganoidsfromhumaninducedpluripotentstemcells AT alexanderstuffer generationofmesenchymefreeintestinalorganoidsfromhumaninducedpluripotentstemcells AT johnmahoney generationofmesenchymefreeintestinalorganoidsfromhumaninducedpluripotentstemcells AT darrellnkotton generationofmesenchymefreeintestinalorganoidsfromhumaninducedpluripotentstemcells AT finnhawkins generationofmesenchymefreeintestinalorganoidsfromhumaninducedpluripotentstemcells AT gustavomostoslavsky generationofmesenchymefreeintestinalorganoidsfromhumaninducedpluripotentstemcells
_version_	1718390209535541248

Generation of mesenchyme free intestinal organoids from human induced pluripotent stem cells

Ejemplares similares