HbA1c is inversely associated with thyroid cysts in a euthyroid population: A cross-sectional study.

Anti-thyroid peroxidase antibody (TPO-Ab) is revealed to be inversely associated with thyroid cysts among euthyroid population. TPO-Ab causes autoimmune thyroiditis by bolstering thyroid inflammation. Therefore, at least partly, absence of thyroid cysts could indicate latent thyroid damage. Since pa...

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Autores principales:	Yuji Shimizu, Shin-Ya Kawashiri, Yuko Noguchi, Yasuhiro Nagata, Takahiro Maeda, Naomi Hayashida
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/efa81e5be017474dbc20a65b220b59c9
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spelling	oai:doaj.org-article:efa81e5be017474dbc20a65b220b59c92021-12-02T20:15:42ZHbA1c is inversely associated with thyroid cysts in a euthyroid population: A cross-sectional study.1932-620310.1371/journal.pone.0253841https://doaj.org/article/efa81e5be017474dbc20a65b220b59c92021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0253841https://doaj.org/toc/1932-6203Anti-thyroid peroxidase antibody (TPO-Ab) is revealed to be inversely associated with thyroid cysts among euthyroid population. TPO-Ab causes autoimmune thyroiditis by bolstering thyroid inflammation. Therefore, at least partly, absence of thyroid cysts could indicate latent thyroid damage. Since participants with subclinical hypothyroidism are reported to have higher HbA1c than normal healthy controls, HbA1c could be inversely associated with thyroid cysts through a mechanism reflecting latent thyroid damage. To investigate the association between HbA1c and thyroid cysts among a euthyroid population, a cross-sectional study was conducted on 1,724 Japanese individuals who were within the normal range of thyroid function [i.e., normal range of free triiodothyronine (T3) and free thyroxine (T4)] and aged 40-74 years. Among this study population, 564 were diagnosed with thyroid cysts. Independently of thyroid related hormones [thyroid stimulating hormone (TSH), free T3, and free T4] and known cardiovascular risk factors, HbA1c was found to be significantly inversely associated with the presence of thyroid cysts. This association remained significant even after this analysis was limited to participants within a normal range of TSH. The fully adjusted odds ratios (ORs) of thyroid cysts for 1 standard deviation (SD) increment of HbA1c were 0.84 (0.74, 0.95) for total participants and 0.80 (0.70, 0.92) for participants within a normal range of TSH. Among participants with normal thyroid function, HbA1c was inversely associated with the presence of thyroid cysts. The absence of thyroid cysts and higher levels of HbA1c could indicate the latent functional damage of the thyroid.Yuji ShimizuShin-Ya KawashiriYuko NoguchiYasuhiro NagataTakahiro MaedaNaomi HayashidaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 6, p e0253841 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yuji Shimizu Shin-Ya Kawashiri Yuko Noguchi Yasuhiro Nagata Takahiro Maeda Naomi Hayashida HbA1c is inversely associated with thyroid cysts in a euthyroid population: A cross-sectional study.
description	Anti-thyroid peroxidase antibody (TPO-Ab) is revealed to be inversely associated with thyroid cysts among euthyroid population. TPO-Ab causes autoimmune thyroiditis by bolstering thyroid inflammation. Therefore, at least partly, absence of thyroid cysts could indicate latent thyroid damage. Since participants with subclinical hypothyroidism are reported to have higher HbA1c than normal healthy controls, HbA1c could be inversely associated with thyroid cysts through a mechanism reflecting latent thyroid damage. To investigate the association between HbA1c and thyroid cysts among a euthyroid population, a cross-sectional study was conducted on 1,724 Japanese individuals who were within the normal range of thyroid function [i.e., normal range of free triiodothyronine (T3) and free thyroxine (T4)] and aged 40-74 years. Among this study population, 564 were diagnosed with thyroid cysts. Independently of thyroid related hormones [thyroid stimulating hormone (TSH), free T3, and free T4] and known cardiovascular risk factors, HbA1c was found to be significantly inversely associated with the presence of thyroid cysts. This association remained significant even after this analysis was limited to participants within a normal range of TSH. The fully adjusted odds ratios (ORs) of thyroid cysts for 1 standard deviation (SD) increment of HbA1c were 0.84 (0.74, 0.95) for total participants and 0.80 (0.70, 0.92) for participants within a normal range of TSH. Among participants with normal thyroid function, HbA1c was inversely associated with the presence of thyroid cysts. The absence of thyroid cysts and higher levels of HbA1c could indicate the latent functional damage of the thyroid.
format	article
author	Yuji Shimizu Shin-Ya Kawashiri Yuko Noguchi Yasuhiro Nagata Takahiro Maeda Naomi Hayashida
author_facet	Yuji Shimizu Shin-Ya Kawashiri Yuko Noguchi Yasuhiro Nagata Takahiro Maeda Naomi Hayashida
author_sort	Yuji Shimizu
title	HbA1c is inversely associated with thyroid cysts in a euthyroid population: A cross-sectional study.
title_short	HbA1c is inversely associated with thyroid cysts in a euthyroid population: A cross-sectional study.
title_full	HbA1c is inversely associated with thyroid cysts in a euthyroid population: A cross-sectional study.
title_fullStr	HbA1c is inversely associated with thyroid cysts in a euthyroid population: A cross-sectional study.
title_full_unstemmed	HbA1c is inversely associated with thyroid cysts in a euthyroid population: A cross-sectional study.
title_sort	hba1c is inversely associated with thyroid cysts in a euthyroid population: a cross-sectional study.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/efa81e5be017474dbc20a65b220b59c9
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HbA1c is inversely associated with thyroid cysts in a euthyroid population: A cross-sectional study.

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