Retrograde degeneration of retinal ganglion cells in homonymous hemianopsia

Angela M Herro, Byron L Lam Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami Miller School of Medicine, Miami, FL, USA Background: The aim of this study was to demonstrate the relationship between topographic reduction in macular ganglion cell complex (GCC) th...

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Autores principales:	Herro AM, Lam BL
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/efaafd6cd32449d689cda6e10795ded6
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spelling	oai:doaj.org-article:efaafd6cd32449d689cda6e10795ded62021-12-02T05:36:57ZRetrograde degeneration of retinal ganglion cells in homonymous hemianopsia1177-5483https://doaj.org/article/efaafd6cd32449d689cda6e10795ded62015-06-01T00:00:00Zhttp://www.dovepress.com/retrograde-degeneration-of-retinal-ganglion-cells-in-homonymous-hemian-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Angela M Herro, Byron L Lam Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami Miller School of Medicine, Miami, FL, USA Background: The aim of this study was to demonstrate the relationship between topographic reduction in macular ganglion cell complex (GCC) thickness as detected with spectral-domain optical coherence tomography and visual field defects caused by ischemic occipital cortical injury.Methods: This study was a retrospective review of all patients who presented to our eye institution between January 2012 and July 2014 with visual field defects secondary to ischemic cortical injury. The visual field defect pattern and mean deviation were analyzed. Retinal nerve fiber layer (RNFL) and macular GCC were both assessed with spectral-domain optical coherence tomography. Patients with any ocular pathology that could affect these measurements were excluded. The topographic relationship of visual field defect to reduction in GCC was specifically analyzed. Results: Nine patients met the inclusion criteria. Their average age was 65 (57–73) years; eight were men and six had right hemianopsias. The laterality of the visual field defect was used to assign an affected and unaffected side of analysis for RNFL and GCC layer thickness. A right hemianopsia meant that the nasal fibers of the right eye and temporal fibers of the left eye were assigned as the “affected side”, and the temporal fibers of the right eye and nasal fibers of the left eye were assigned as “unaffected”. There was no statistically significant difference between affected and unaffected RNFL. However, there was a significant difference in GCC layer reduction between the affected and unaffected sides (P=0.029).Conclusion: There is evidence of retrograde trans-synaptic retinal ganglion cell loss in patients with homonymous hemianopsias from cortical visual impairment. This relationship is reflected in thinning of the GCC and maintains the topographic relationship of the visual field defect. Keywords: homonymous hemianopsia, ganglion cell complex, occipital lobeHerro AMLam BLDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2015, Iss default, Pp 1057-1064 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Herro AM Lam BL Retrograde degeneration of retinal ganglion cells in homonymous hemianopsia
description	Angela M Herro, Byron L Lam Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami Miller School of Medicine, Miami, FL, USA Background: The aim of this study was to demonstrate the relationship between topographic reduction in macular ganglion cell complex (GCC) thickness as detected with spectral-domain optical coherence tomography and visual field defects caused by ischemic occipital cortical injury.Methods: This study was a retrospective review of all patients who presented to our eye institution between January 2012 and July 2014 with visual field defects secondary to ischemic cortical injury. The visual field defect pattern and mean deviation were analyzed. Retinal nerve fiber layer (RNFL) and macular GCC were both assessed with spectral-domain optical coherence tomography. Patients with any ocular pathology that could affect these measurements were excluded. The topographic relationship of visual field defect to reduction in GCC was specifically analyzed. Results: Nine patients met the inclusion criteria. Their average age was 65 (57–73) years; eight were men and six had right hemianopsias. The laterality of the visual field defect was used to assign an affected and unaffected side of analysis for RNFL and GCC layer thickness. A right hemianopsia meant that the nasal fibers of the right eye and temporal fibers of the left eye were assigned as the “affected side”, and the temporal fibers of the right eye and nasal fibers of the left eye were assigned as “unaffected”. There was no statistically significant difference between affected and unaffected RNFL. However, there was a significant difference in GCC layer reduction between the affected and unaffected sides (P=0.029).Conclusion: There is evidence of retrograde trans-synaptic retinal ganglion cell loss in patients with homonymous hemianopsias from cortical visual impairment. This relationship is reflected in thinning of the GCC and maintains the topographic relationship of the visual field defect. Keywords: homonymous hemianopsia, ganglion cell complex, occipital lobe
format	article
author	Herro AM Lam BL
author_facet	Herro AM Lam BL
author_sort	Herro AM
title	Retrograde degeneration of retinal ganglion cells in homonymous hemianopsia
title_short	Retrograde degeneration of retinal ganglion cells in homonymous hemianopsia
title_full	Retrograde degeneration of retinal ganglion cells in homonymous hemianopsia
title_fullStr	Retrograde degeneration of retinal ganglion cells in homonymous hemianopsia
title_full_unstemmed	Retrograde degeneration of retinal ganglion cells in homonymous hemianopsia
title_sort	retrograde degeneration of retinal ganglion cells in homonymous hemianopsia
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/efaafd6cd32449d689cda6e10795ded6
work_keys_str_mv	AT herroam retrogradedegenerationofretinalganglioncellsinhomonymoushemianopsia AT lambl retrogradedegenerationofretinalganglioncellsinhomonymoushemianopsia
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Retrograde degeneration of retinal ganglion cells in homonymous hemianopsia

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