Non-canonical Wnt signalling regulates scarring in biliary disease via the planar cell polarity receptors

Non-canonical Wnt signalling regulates scarring in biliary disease via the planar cell polarity receptors

In fibrotic biliary disease, portal fibroblasts promote both biliary scarring and bile duct regeneration. Here, the authors report that the non-canonical Wnt-PCP signalling promotes bile duct scarring in mice, and inhibition of Wnt-ligands reduces the scarring without impairing regeneration.

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Detalles Bibliográficos
Autores principales: D. H. Wilson, E. J. Jarman, R. P. Mellin, M. L. Wilson, S. H. Waddell, P. Tsokkou, N. T. Younger, A. Raven, S. R. Bhalla, A. T. R. Noll, S. W. Olde Damink, F. G. Schaap, P. Chen, D. O. Bates, J. M. Banales, C. H. Dean, D. J. Henderson, O. J. Sansom, T. J. Kendall, L. Boulter
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
Materias:
Science
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Acceso en línea:https://doaj.org/article/efac863794d6438ba5adb94c1e3b8e19
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Sumario:In fibrotic biliary disease, portal fibroblasts promote both biliary scarring and bile duct regeneration. Here, the authors report that the non-canonical Wnt-PCP signalling promotes bile duct scarring in mice, and inhibition of Wnt-ligands reduces the scarring without impairing regeneration.

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