Non-canonical Wnt signalling regulates scarring in biliary disease via the planar cell polarity receptors

In fibrotic biliary disease, portal fibroblasts promote both biliary scarring and bile duct regeneration. Here, the authors report that the non-canonical Wnt-PCP signalling promotes bile duct scarring in mice, and inhibition of Wnt-ligands reduces the scarring without impairing regeneration.

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Main Authors:	D. H. Wilson, E. J. Jarman, R. P. Mellin, M. L. Wilson, S. H. Waddell, P. Tsokkou, N. T. Younger, A. Raven, S. R. Bhalla, A. T. R. Noll, S. W. Olde Damink, F. G. Schaap, P. Chen, D. O. Bates, J. M. Banales, C. H. Dean, D. J. Henderson, O. J. Sansom, T. J. Kendall, L. Boulter
Format:	article
Language:	EN
Published:	Nature Portfolio 2020
Subjects:	Science Q
Online Access:	https://doaj.org/article/efac863794d6438ba5adb94c1e3b8e19
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spelling	oai:doaj.org-article:efac863794d6438ba5adb94c1e3b8e192021-12-02T17:31:40ZNon-canonical Wnt signalling regulates scarring in biliary disease via the planar cell polarity receptors10.1038/s41467-020-14283-32041-1723https://doaj.org/article/efac863794d6438ba5adb94c1e3b8e192020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14283-3https://doaj.org/toc/2041-1723In fibrotic biliary disease, portal fibroblasts promote both biliary scarring and bile duct regeneration. Here, the authors report that the non-canonical Wnt-PCP signalling promotes bile duct scarring in mice, and inhibition of Wnt-ligands reduces the scarring without impairing regeneration.D. H. WilsonE. J. JarmanR. P. MellinM. L. WilsonS. H. WaddellP. TsokkouN. T. YoungerA. RavenS. R. BhallaA. T. R. NollS. W. Olde DaminkF. G. SchaapP. ChenD. O. BatesJ. M. BanalesC. H. DeanD. J. HendersonO. J. SansomT. J. KendallL. BoulterNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q D. H. Wilson E. J. Jarman R. P. Mellin M. L. Wilson S. H. Waddell P. Tsokkou N. T. Younger A. Raven S. R. Bhalla A. T. R. Noll S. W. Olde Damink F. G. Schaap P. Chen D. O. Bates J. M. Banales C. H. Dean D. J. Henderson O. J. Sansom T. J. Kendall L. Boulter Non-canonical Wnt signalling regulates scarring in biliary disease via the planar cell polarity receptors
description	In fibrotic biliary disease, portal fibroblasts promote both biliary scarring and bile duct regeneration. Here, the authors report that the non-canonical Wnt-PCP signalling promotes bile duct scarring in mice, and inhibition of Wnt-ligands reduces the scarring without impairing regeneration.
format	article
author	D. H. Wilson E. J. Jarman R. P. Mellin M. L. Wilson S. H. Waddell P. Tsokkou N. T. Younger A. Raven S. R. Bhalla A. T. R. Noll S. W. Olde Damink F. G. Schaap P. Chen D. O. Bates J. M. Banales C. H. Dean D. J. Henderson O. J. Sansom T. J. Kendall L. Boulter
author_facet	D. H. Wilson E. J. Jarman R. P. Mellin M. L. Wilson S. H. Waddell P. Tsokkou N. T. Younger A. Raven S. R. Bhalla A. T. R. Noll S. W. Olde Damink F. G. Schaap P. Chen D. O. Bates J. M. Banales C. H. Dean D. J. Henderson O. J. Sansom T. J. Kendall L. Boulter
author_sort	D. H. Wilson
title	Non-canonical Wnt signalling regulates scarring in biliary disease via the planar cell polarity receptors
title_short	Non-canonical Wnt signalling regulates scarring in biliary disease via the planar cell polarity receptors
title_full	Non-canonical Wnt signalling regulates scarring in biliary disease via the planar cell polarity receptors
title_fullStr	Non-canonical Wnt signalling regulates scarring in biliary disease via the planar cell polarity receptors
title_full_unstemmed	Non-canonical Wnt signalling regulates scarring in biliary disease via the planar cell polarity receptors
title_sort	non-canonical wnt signalling regulates scarring in biliary disease via the planar cell polarity receptors
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/efac863794d6438ba5adb94c1e3b8e19
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Non-canonical Wnt signalling regulates scarring in biliary disease via the planar cell polarity receptors

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