Perfusion CT detects alterations in local cerebral flow of glioma related to IDH, MGMT and TERT status

Abstract Background The aim of this study was to investigate the relationship between tumor biology and values of cerebral blood volume (CBV), cerebral blood flow (CBF), mean transit time (MTT), time to peak (TTP), permeability surface (PS) of tumor in patients with glioma. Methods Forty-six patient...

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Autores principales:	Ke Wang, Yeming Li, Haiyang Cheng, Shenjie Li, Wei Xiang, Yang Ming, Ligang Chen, Jie Zhou
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Glioma Molecular pathology Perfusion CT Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/efb3f54f719c4ae4994ed1d175e1c5c1
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spelling	oai:doaj.org-article:efb3f54f719c4ae4994ed1d175e1c5c12021-11-28T12:11:31ZPerfusion CT detects alterations in local cerebral flow of glioma related to IDH, MGMT and TERT status10.1186/s12883-021-02490-41471-2377https://doaj.org/article/efb3f54f719c4ae4994ed1d175e1c5c12021-11-01T00:00:00Zhttps://doi.org/10.1186/s12883-021-02490-4https://doaj.org/toc/1471-2377Abstract Background The aim of this study was to investigate the relationship between tumor biology and values of cerebral blood volume (CBV), cerebral blood flow (CBF), mean transit time (MTT), time to peak (TTP), permeability surface (PS) of tumor in patients with glioma. Methods Forty-six patients with glioma were involved in the study. Histopathologic and molecular pathology diagnoses were obtained by tumor resection, and all patients accepted perfusion computed tomography (PCT) before operation. Regions of interests were placed manually at tumor and contralateral normal-appearing thalamus. The parameters of tumor were divided by those of contralateral normal-appearing thalamus to normalize at tumor (relative [r] CBV, rCBF, rMTT, rTTP, rPS). The relationships of the parameters, world health organization (WHO) grade, molecular pathological findings were analysed. Results The rCBV, rMTT and rPS of patients are positively related to the pathological classification (P < 0.05). The values of rCBV and rPS in IDH mutated patients were lower than those IDH wild-type. The values of rCBF in patients with MGMT methylation were lower than those MGMT unmethylation (P < 0.05). The MVD of TERT wild-type group was lower than TERT mutated group (P < 0.05). The values of rCBV were significant difference in the four molecular groups divided by the combined IDH/TERT classification (P < 0.05). The progression free survival (PFS) and overall survival (OS) were significant difference in the four molecular groups divided by the combined IDH/TERT classification (P < 0.05). Conclusions Our study introduces and supports the changes of glioma flow perfusion may be closely related to its biological characteristics.Ke WangYeming LiHaiyang ChengShenjie LiWei XiangYang MingLigang ChenJie ZhouBMCarticleGliomaMolecular pathologyPerfusion CTNeurology. Diseases of the nervous systemRC346-429ENBMC Neurology, Vol 21, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Glioma Molecular pathology Perfusion CT Neurology. Diseases of the nervous system RC346-429
spellingShingle	Glioma Molecular pathology Perfusion CT Neurology. Diseases of the nervous system RC346-429 Ke Wang Yeming Li Haiyang Cheng Shenjie Li Wei Xiang Yang Ming Ligang Chen Jie Zhou Perfusion CT detects alterations in local cerebral flow of glioma related to IDH, MGMT and TERT status
description	Abstract Background The aim of this study was to investigate the relationship between tumor biology and values of cerebral blood volume (CBV), cerebral blood flow (CBF), mean transit time (MTT), time to peak (TTP), permeability surface (PS) of tumor in patients with glioma. Methods Forty-six patients with glioma were involved in the study. Histopathologic and molecular pathology diagnoses were obtained by tumor resection, and all patients accepted perfusion computed tomography (PCT) before operation. Regions of interests were placed manually at tumor and contralateral normal-appearing thalamus. The parameters of tumor were divided by those of contralateral normal-appearing thalamus to normalize at tumor (relative [r] CBV, rCBF, rMTT, rTTP, rPS). The relationships of the parameters, world health organization (WHO) grade, molecular pathological findings were analysed. Results The rCBV, rMTT and rPS of patients are positively related to the pathological classification (P < 0.05). The values of rCBV and rPS in IDH mutated patients were lower than those IDH wild-type. The values of rCBF in patients with MGMT methylation were lower than those MGMT unmethylation (P < 0.05). The MVD of TERT wild-type group was lower than TERT mutated group (P < 0.05). The values of rCBV were significant difference in the four molecular groups divided by the combined IDH/TERT classification (P < 0.05). The progression free survival (PFS) and overall survival (OS) were significant difference in the four molecular groups divided by the combined IDH/TERT classification (P < 0.05). Conclusions Our study introduces and supports the changes of glioma flow perfusion may be closely related to its biological characteristics.
format	article
author	Ke Wang Yeming Li Haiyang Cheng Shenjie Li Wei Xiang Yang Ming Ligang Chen Jie Zhou
author_facet	Ke Wang Yeming Li Haiyang Cheng Shenjie Li Wei Xiang Yang Ming Ligang Chen Jie Zhou
author_sort	Ke Wang
title	Perfusion CT detects alterations in local cerebral flow of glioma related to IDH, MGMT and TERT status
title_short	Perfusion CT detects alterations in local cerebral flow of glioma related to IDH, MGMT and TERT status
title_full	Perfusion CT detects alterations in local cerebral flow of glioma related to IDH, MGMT and TERT status
title_fullStr	Perfusion CT detects alterations in local cerebral flow of glioma related to IDH, MGMT and TERT status
title_full_unstemmed	Perfusion CT detects alterations in local cerebral flow of glioma related to IDH, MGMT and TERT status
title_sort	perfusion ct detects alterations in local cerebral flow of glioma related to idh, mgmt and tert status
publisher	BMC
publishDate	2021
url	https://doaj.org/article/efb3f54f719c4ae4994ed1d175e1c5c1
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Perfusion CT detects alterations in local cerebral flow of glioma related to IDH, MGMT and TERT status

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