High "normal" blood glucose is associated with decreased brain volume and cognitive performance in the 60s: the PATH through life study.

<h4>Context</h4>Type 2 diabetes is associated with cerebral atrophy, cognitive impairment and dementia. We recently showed higher glucose levels in the normal range not to be free of adverse effects and to be associated with greater hippocampal and amygdalar atrophy in older community-dw...

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Autores principales:	Moyra E Mortby, Andrew L Janke, Kaarin J Anstey, Perminder S Sachdev, Nicolas Cherbuin
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/efb9f4b17a18491c9a0ff773c6620b16
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spelling	oai:doaj.org-article:efb9f4b17a18491c9a0ff773c6620b162021-11-18T08:56:54ZHigh "normal" blood glucose is associated with decreased brain volume and cognitive performance in the 60s: the PATH through life study.1932-620310.1371/journal.pone.0073697https://doaj.org/article/efb9f4b17a18491c9a0ff773c6620b162013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24023897/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Context</h4>Type 2 diabetes is associated with cerebral atrophy, cognitive impairment and dementia. We recently showed higher glucose levels in the normal range not to be free of adverse effects and to be associated with greater hippocampal and amygdalar atrophy in older community-dwelling individuals free of diabetes.<h4>Objective</h4>This study aimed to determine whether blood glucose levels in the normal range (<6.1 mmol/L) were associated with cerebral volumes in structures other than the hippocampus and amygdale, and whether these glucose-related regional volumes were associated with cognitive performance.<h4>Design setting and participants</h4>210 cognitively healthy individuals (68-73 years) without diabetes, glucose intolerance or metabolic syndrome were assessed in the large, community-based Personality and Total Health Through Life (PATH) study.<h4>Main outcome measure</h4>Baseline blood glucose levels in the normal range (3.2-6.1 mmol/l) were used to determine regional brain volumes and associated cognitive function at wave 3.<h4>Results</h4>Higher blood glucose levels in the normal range were associated with lower grey/white matter regional volumes in the frontal cortices (middle frontal gyrus, inferior frontal gyrus precentral gyrus). Moreover, identified cerebral regions were associated with poorer cognitive performance and the structure-function associations were gender specific to men.<h4>Conclusion</h4>These findings stress the need to re-evaluate what is considered as healthy blood glucose levels, and consider the role of higher normal blood glucose as a risk factor for cerebral health, cognitive function and dementia. A better lifetime management of blood glucose levels may contribute to improved cerebral and cognitive health in later life and possibly protect against dementia.Moyra E MortbyAndrew L JankeKaarin J AnsteyPerminder S SachdevNicolas CherbuinPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 9, p e73697 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Moyra E Mortby Andrew L Janke Kaarin J Anstey Perminder S Sachdev Nicolas Cherbuin High "normal" blood glucose is associated with decreased brain volume and cognitive performance in the 60s: the PATH through life study.
description	<h4>Context</h4>Type 2 diabetes is associated with cerebral atrophy, cognitive impairment and dementia. We recently showed higher glucose levels in the normal range not to be free of adverse effects and to be associated with greater hippocampal and amygdalar atrophy in older community-dwelling individuals free of diabetes.<h4>Objective</h4>This study aimed to determine whether blood glucose levels in the normal range (<6.1 mmol/L) were associated with cerebral volumes in structures other than the hippocampus and amygdale, and whether these glucose-related regional volumes were associated with cognitive performance.<h4>Design setting and participants</h4>210 cognitively healthy individuals (68-73 years) without diabetes, glucose intolerance or metabolic syndrome were assessed in the large, community-based Personality and Total Health Through Life (PATH) study.<h4>Main outcome measure</h4>Baseline blood glucose levels in the normal range (3.2-6.1 mmol/l) were used to determine regional brain volumes and associated cognitive function at wave 3.<h4>Results</h4>Higher blood glucose levels in the normal range were associated with lower grey/white matter regional volumes in the frontal cortices (middle frontal gyrus, inferior frontal gyrus precentral gyrus). Moreover, identified cerebral regions were associated with poorer cognitive performance and the structure-function associations were gender specific to men.<h4>Conclusion</h4>These findings stress the need to re-evaluate what is considered as healthy blood glucose levels, and consider the role of higher normal blood glucose as a risk factor for cerebral health, cognitive function and dementia. A better lifetime management of blood glucose levels may contribute to improved cerebral and cognitive health in later life and possibly protect against dementia.
format	article
author	Moyra E Mortby Andrew L Janke Kaarin J Anstey Perminder S Sachdev Nicolas Cherbuin
author_facet	Moyra E Mortby Andrew L Janke Kaarin J Anstey Perminder S Sachdev Nicolas Cherbuin
author_sort	Moyra E Mortby
title	High "normal" blood glucose is associated with decreased brain volume and cognitive performance in the 60s: the PATH through life study.
title_short	High "normal" blood glucose is associated with decreased brain volume and cognitive performance in the 60s: the PATH through life study.
title_full	High "normal" blood glucose is associated with decreased brain volume and cognitive performance in the 60s: the PATH through life study.
title_fullStr	High "normal" blood glucose is associated with decreased brain volume and cognitive performance in the 60s: the PATH through life study.
title_full_unstemmed	High "normal" blood glucose is associated with decreased brain volume and cognitive performance in the 60s: the PATH through life study.
title_sort	high "normal" blood glucose is associated with decreased brain volume and cognitive performance in the 60s: the path through life study.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/efb9f4b17a18491c9a0ff773c6620b16
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High "normal" blood glucose is associated with decreased brain volume and cognitive performance in the 60s: the PATH through life study.

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