Effects of Female Sexual Hormones on the Gastric Motility Activity following Traumatic Brain Injury in Female Rats

BACKGROUND AND OBJECTIVE: Gastrointestinal function disorder was seen frequently in traumatic patients. In regarding to useful role of sexual hormones on gastrointestinal motility disorders, the aim of this study was to evaluate the effects of female sexual hormones on the gastric motility following...

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Autores principales:	Z Keshavarzi, M Khaksari Haddad
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2012
Materias:	brain injury estradiol progesterone marmarou Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/efba62e3686949599dd0c1c78ef04477
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spelling	oai:doaj.org-article:efba62e3686949599dd0c1c78ef044772021-11-10T08:53:33ZEffects of Female Sexual Hormones on the Gastric Motility Activity following Traumatic Brain Injury in Female Rats1561-41072251-7170https://doaj.org/article/efba62e3686949599dd0c1c78ef044772012-11-01T00:00:00Zhttp://jbums.org/article-1-4233-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND AND OBJECTIVE: Gastrointestinal function disorder was seen frequently in traumatic patients. In regarding to useful role of sexual hormones on gastrointestinal motility disorders, the aim of this study was to evaluate the effects of female sexual hormones on the gastric motility following TBI induction in female rats.METHODS: This experimental study was done on the 63 Wistar female rats (200-250 g) that they were divided to 9 groups involving: intact, OVX (ovariectomized rat), Sham+OVX, TBI (intact rats under TBI), TBI+OVX (ovariectomized rats under TBI) and OVX+TBI rats treated with vehicle, estradiol, progesterone or estradiol+ progesterone combination. Diffuse TBI was induced by Marmarou method. Intragastric pressure, contraction frequency and motility index were measured 5 days after the TBI induction by power lab device and balloon technique.FINDINGS: The intragastric pressure (IGP) was decreased in OVX (6.98 ± 0.3), TBI (7.34 ± 0.3) and TBI+OVX (6.04 ± 0.1) (p<0.01) and treatment with estradiol (7.58 ± 0.5) and estradiol+progesterone (7.92 ± 0.5) increased IGP (p<0.01). Motility index also was decreased following TBI and estradiol+progesterone combination significantly increased the motility index (4.1± 0.4) (p<0.05, p<0.01). CONCLUSION: The main effects of brain trauma and sexual hormones were done principally by changing of gastric smooth muscle contraction activity not frequency of gastric contractions.Z Keshavarzi,M Khaksari HaddadBabol University of Medical Sciencesarticlebrain injuryestradiolprogesteronemarmarouMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 14, Iss 6, Pp 68-76 (2012)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	brain injury estradiol progesterone marmarou Medicine R Medicine (General) R5-920
spellingShingle	brain injury estradiol progesterone marmarou Medicine R Medicine (General) R5-920 Z Keshavarzi, M Khaksari Haddad Effects of Female Sexual Hormones on the Gastric Motility Activity following Traumatic Brain Injury in Female Rats
description	BACKGROUND AND OBJECTIVE: Gastrointestinal function disorder was seen frequently in traumatic patients. In regarding to useful role of sexual hormones on gastrointestinal motility disorders, the aim of this study was to evaluate the effects of female sexual hormones on the gastric motility following TBI induction in female rats.METHODS: This experimental study was done on the 63 Wistar female rats (200-250 g) that they were divided to 9 groups involving: intact, OVX (ovariectomized rat), Sham+OVX, TBI (intact rats under TBI), TBI+OVX (ovariectomized rats under TBI) and OVX+TBI rats treated with vehicle, estradiol, progesterone or estradiol+ progesterone combination. Diffuse TBI was induced by Marmarou method. Intragastric pressure, contraction frequency and motility index were measured 5 days after the TBI induction by power lab device and balloon technique.FINDINGS: The intragastric pressure (IGP) was decreased in OVX (6.98 ± 0.3), TBI (7.34 ± 0.3) and TBI+OVX (6.04 ± 0.1) (p<0.01) and treatment with estradiol (7.58 ± 0.5) and estradiol+progesterone (7.92 ± 0.5) increased IGP (p<0.01). Motility index also was decreased following TBI and estradiol+progesterone combination significantly increased the motility index (4.1± 0.4) (p<0.05, p<0.01). CONCLUSION: The main effects of brain trauma and sexual hormones were done principally by changing of gastric smooth muscle contraction activity not frequency of gastric contractions.
format	article
author	Z Keshavarzi, M Khaksari Haddad
author_facet	Z Keshavarzi, M Khaksari Haddad
author_sort	Z Keshavarzi,
title	Effects of Female Sexual Hormones on the Gastric Motility Activity following Traumatic Brain Injury in Female Rats
title_short	Effects of Female Sexual Hormones on the Gastric Motility Activity following Traumatic Brain Injury in Female Rats
title_full	Effects of Female Sexual Hormones on the Gastric Motility Activity following Traumatic Brain Injury in Female Rats
title_fullStr	Effects of Female Sexual Hormones on the Gastric Motility Activity following Traumatic Brain Injury in Female Rats
title_full_unstemmed	Effects of Female Sexual Hormones on the Gastric Motility Activity following Traumatic Brain Injury in Female Rats
title_sort	effects of female sexual hormones on the gastric motility activity following traumatic brain injury in female rats
publisher	Babol University of Medical Sciences
publishDate	2012
url	https://doaj.org/article/efba62e3686949599dd0c1c78ef04477
work_keys_str_mv	AT zkeshavarzi effectsoffemalesexualhormonesonthegastricmotilityactivityfollowingtraumaticbraininjuryinfemalerats AT mkhaksarihaddad effectsoffemalesexualhormonesonthegastricmotilityactivityfollowingtraumaticbraininjuryinfemalerats
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Effects of Female Sexual Hormones on the Gastric Motility Activity following Traumatic Brain Injury in Female Rats

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