Millisecond-timescale local network coding in the rat primary somatosensory cortex.

Correlation among neocortical neurons is thought to play an indispensable role in mediating sensory processing of external stimuli. The role of temporal precision in this correlation has been hypothesized to enhance information flow along sensory pathways. Its role in mediating the integration of in...

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Autores principales:	Seif Eldawlatly, Karim G Oweiss
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/efbbe0de9f17485caa67a47983364958
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spelling	oai:doaj.org-article:efbbe0de9f17485caa67a479833649582021-11-18T06:50:59ZMillisecond-timescale local network coding in the rat primary somatosensory cortex.1932-620310.1371/journal.pone.0021649https://doaj.org/article/efbbe0de9f17485caa67a479833649582011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21738751/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Correlation among neocortical neurons is thought to play an indispensable role in mediating sensory processing of external stimuli. The role of temporal precision in this correlation has been hypothesized to enhance information flow along sensory pathways. Its role in mediating the integration of information at the output of these pathways, however, remains poorly understood. Here, we examined spike timing correlation between simultaneously recorded layer V neurons within and across columns of the primary somatosensory cortex of anesthetized rats during unilateral whisker stimulation. We used bayesian statistics and information theory to quantify the causal influence between the recorded cells with millisecond precision. For each stimulated whisker, we inferred stable, whisker-specific, dynamic bayesian networks over many repeated trials, with network similarity of 83.3±6% within whisker, compared to only 50.3±18% across whiskers. These networks further provided information about whisker identity that was approximately 6 times higher than what was provided by the latency to first spike and 13 times higher than what was provided by the spike count of individual neurons examined separately. Furthermore, prediction of individual neurons' precise firing conditioned on knowledge of putative pre-synaptic cell firing was 3 times higher than predictions conditioned on stimulus onset alone. Taken together, these results suggest the presence of a temporally precise network coding mechanism that integrates information across neighboring columns within layer V about vibrissa position and whisking kinetics to mediate whisker movement by motor areas innervated by layer V.Seif EldawlatlyKarim G OweissPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 6, p e21649 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Seif Eldawlatly Karim G Oweiss Millisecond-timescale local network coding in the rat primary somatosensory cortex.
description	Correlation among neocortical neurons is thought to play an indispensable role in mediating sensory processing of external stimuli. The role of temporal precision in this correlation has been hypothesized to enhance information flow along sensory pathways. Its role in mediating the integration of information at the output of these pathways, however, remains poorly understood. Here, we examined spike timing correlation between simultaneously recorded layer V neurons within and across columns of the primary somatosensory cortex of anesthetized rats during unilateral whisker stimulation. We used bayesian statistics and information theory to quantify the causal influence between the recorded cells with millisecond precision. For each stimulated whisker, we inferred stable, whisker-specific, dynamic bayesian networks over many repeated trials, with network similarity of 83.3±6% within whisker, compared to only 50.3±18% across whiskers. These networks further provided information about whisker identity that was approximately 6 times higher than what was provided by the latency to first spike and 13 times higher than what was provided by the spike count of individual neurons examined separately. Furthermore, prediction of individual neurons' precise firing conditioned on knowledge of putative pre-synaptic cell firing was 3 times higher than predictions conditioned on stimulus onset alone. Taken together, these results suggest the presence of a temporally precise network coding mechanism that integrates information across neighboring columns within layer V about vibrissa position and whisking kinetics to mediate whisker movement by motor areas innervated by layer V.
format	article
author	Seif Eldawlatly Karim G Oweiss
author_facet	Seif Eldawlatly Karim G Oweiss
author_sort	Seif Eldawlatly
title	Millisecond-timescale local network coding in the rat primary somatosensory cortex.
title_short	Millisecond-timescale local network coding in the rat primary somatosensory cortex.
title_full	Millisecond-timescale local network coding in the rat primary somatosensory cortex.
title_fullStr	Millisecond-timescale local network coding in the rat primary somatosensory cortex.
title_full_unstemmed	Millisecond-timescale local network coding in the rat primary somatosensory cortex.
title_sort	millisecond-timescale local network coding in the rat primary somatosensory cortex.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/efbbe0de9f17485caa67a47983364958
work_keys_str_mv	AT seifeldawlatly millisecondtimescalelocalnetworkcodingintheratprimarysomatosensorycortex AT karimgoweiss millisecondtimescalelocalnetworkcodingintheratprimarysomatosensorycortex
_version_	1718424328267104256

Millisecond-timescale local network coding in the rat primary somatosensory cortex.

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