Occupational exposure to heavy metals, alcohol intake, and risk of type 2 diabetes and prediabetes among Chinese male workers
Objective: Both exposure to heavy metals and alcohol intake have been related to the risk of type 2 diabetes (T2D). In this study, we aimed to assess the potential interactions between metal exposure and alcohol intake on the risk of T2D and prediabetes in a cohort of Chinese male workers. Methods:...
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KeAi Communications Co., Ltd.
2019
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oai:doaj.org-article:efbde399eb724f79951bc3b0cf84349f2021-12-02T12:53:55ZOccupational exposure to heavy metals, alcohol intake, and risk of type 2 diabetes and prediabetes among Chinese male workers2095-882X10.1016/j.cdtm.2019.05.002https://doaj.org/article/efbde399eb724f79951bc3b0cf84349f2019-06-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2095882X19300349https://doaj.org/toc/2095-882XObjective: Both exposure to heavy metals and alcohol intake have been related to the risk of type 2 diabetes (T2D). In this study, we aimed to assess the potential interactions between metal exposure and alcohol intake on the risk of T2D and prediabetes in a cohort of Chinese male workers. Methods: We conducted a cross-sectional analysis of 26,008 Chinese male workers in an occupational cohort study from 2011 to 2013. We assessed metal exposure and alcohol consumption at baseline in these workers who were aged ≥20 years. Based on occupations which were categorized according to measured urine metal levels, multiple logistic regression analyses were used to evaluate the independent and joint effects of metal and alcohol exposure on the risk of T2D and prediabetes. Results: Risks of T2D (Ptrend = 0.001) and prediabetes (Ptrend = 0.001) were significantly elevated with increasing number of standard drinks per week, years of drinking, and lifetime alcohol consumption. An adjusted odds ratio (OR) of 6.1 (95% confidence interval [CI]: 4.8–7.8) was observed for the smelting/refining workers (highest metal exposure levels) who had the highest lifetime alcohol consumption (>873 kg) (Pinteraction = 0.018), whereas no statistically significant joint effect was found for prediabetes (Pinteraction = 0.515). Conclusions: Both exposures to metal and heavy alcohol intake were associated with the risk of diabetes in this large cohort of male workers. There was a strong interaction between these two exposures in affecting diabetes risk that needs to be confirmed in future studies. Keywords: Metals, Alcohol, Type 2 diabetes, Prediabetes, InteractionAi-Min YangXiao-Bin HuSimin LiuNing ChengDe-Sheng ZhangJuan-Sheng LiHai-Yan LiXiao-Wei RenNa LiXi-Pin ShengJiao DingShan ZhengMin-Zheng WangTong-Zhang ZhengYa-Na BaiKeAi Communications Co., Ltd.articleMedicine (General)R5-920ENChronic Diseases and Translational Medicine, Vol 5, Iss 2, Pp 97-104 (2019) |
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DOAJ |
| collection |
DOAJ |
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EN |
| topic |
Medicine (General) R5-920 |
| spellingShingle |
Medicine (General) R5-920 Ai-Min Yang Xiao-Bin Hu Simin Liu Ning Cheng De-Sheng Zhang Juan-Sheng Li Hai-Yan Li Xiao-Wei Ren Na Li Xi-Pin Sheng Jiao Ding Shan Zheng Min-Zheng Wang Tong-Zhang Zheng Ya-Na Bai Occupational exposure to heavy metals, alcohol intake, and risk of type 2 diabetes and prediabetes among Chinese male workers |
| description |
Objective: Both exposure to heavy metals and alcohol intake have been related to the risk of type 2 diabetes (T2D). In this study, we aimed to assess the potential interactions between metal exposure and alcohol intake on the risk of T2D and prediabetes in a cohort of Chinese male workers. Methods: We conducted a cross-sectional analysis of 26,008 Chinese male workers in an occupational cohort study from 2011 to 2013. We assessed metal exposure and alcohol consumption at baseline in these workers who were aged ≥20 years. Based on occupations which were categorized according to measured urine metal levels, multiple logistic regression analyses were used to evaluate the independent and joint effects of metal and alcohol exposure on the risk of T2D and prediabetes. Results: Risks of T2D (Ptrend = 0.001) and prediabetes (Ptrend = 0.001) were significantly elevated with increasing number of standard drinks per week, years of drinking, and lifetime alcohol consumption. An adjusted odds ratio (OR) of 6.1 (95% confidence interval [CI]: 4.8–7.8) was observed for the smelting/refining workers (highest metal exposure levels) who had the highest lifetime alcohol consumption (>873 kg) (Pinteraction = 0.018), whereas no statistically significant joint effect was found for prediabetes (Pinteraction = 0.515). Conclusions: Both exposures to metal and heavy alcohol intake were associated with the risk of diabetes in this large cohort of male workers. There was a strong interaction between these two exposures in affecting diabetes risk that needs to be confirmed in future studies. Keywords: Metals, Alcohol, Type 2 diabetes, Prediabetes, Interaction |
| format |
article |
| author |
Ai-Min Yang Xiao-Bin Hu Simin Liu Ning Cheng De-Sheng Zhang Juan-Sheng Li Hai-Yan Li Xiao-Wei Ren Na Li Xi-Pin Sheng Jiao Ding Shan Zheng Min-Zheng Wang Tong-Zhang Zheng Ya-Na Bai |
| author_facet |
Ai-Min Yang Xiao-Bin Hu Simin Liu Ning Cheng De-Sheng Zhang Juan-Sheng Li Hai-Yan Li Xiao-Wei Ren Na Li Xi-Pin Sheng Jiao Ding Shan Zheng Min-Zheng Wang Tong-Zhang Zheng Ya-Na Bai |
| author_sort |
Ai-Min Yang |
| title |
Occupational exposure to heavy metals, alcohol intake, and risk of type 2 diabetes and prediabetes among Chinese male workers |
| title_short |
Occupational exposure to heavy metals, alcohol intake, and risk of type 2 diabetes and prediabetes among Chinese male workers |
| title_full |
Occupational exposure to heavy metals, alcohol intake, and risk of type 2 diabetes and prediabetes among Chinese male workers |
| title_fullStr |
Occupational exposure to heavy metals, alcohol intake, and risk of type 2 diabetes and prediabetes among Chinese male workers |
| title_full_unstemmed |
Occupational exposure to heavy metals, alcohol intake, and risk of type 2 diabetes and prediabetes among Chinese male workers |
| title_sort |
occupational exposure to heavy metals, alcohol intake, and risk of type 2 diabetes and prediabetes among chinese male workers |
| publisher |
KeAi Communications Co., Ltd. |
| publishDate |
2019 |
| url |
https://doaj.org/article/efbde399eb724f79951bc3b0cf84349f |
| work_keys_str_mv |
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