Colon Cancer-Related Genes Identification and Function Study Based on Single-Cell Multi-Omics Integration

Transcriptomes and DNA methylation of colon cancer at the single-cell level are used to identify marker genes and improve diagnoses and therapies. Seven colon cancer subtypes are recognized based on the single-cell RNA sequence, and the differentially expressed genes regulated by dysregulated methyl...

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Autores principales:	Xuepu Sun, Yu Guo, Yu Zhang, Peng Zhao, Zhaoqing Wang, Zheng Wei, Haiquan Qiao
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	colon cancer single cell transcriptome methylation comprehensive analysis marker genes Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/efc026ddae1b40488cf0c8cf454075f8
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spelling	oai:doaj.org-article:efc026ddae1b40488cf0c8cf454075f82021-12-01T02:50:05ZColon Cancer-Related Genes Identification and Function Study Based on Single-Cell Multi-Omics Integration2296-634X10.3389/fcell.2021.789587https://doaj.org/article/efc026ddae1b40488cf0c8cf454075f82021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcell.2021.789587/fullhttps://doaj.org/toc/2296-634XTranscriptomes and DNA methylation of colon cancer at the single-cell level are used to identify marker genes and improve diagnoses and therapies. Seven colon cancer subtypes are recognized based on the single-cell RNA sequence, and the differentially expressed genes regulated by dysregulated methylation are identified as marker genes for different types of colon cancer. Compared with normal colon cells, marker genes of different types show very obvious specificity, especially upregulated genes in tumors. Functional enrichment analysis for marker genes indicates a possible relation between colon cancer and nervous system disease, moreover, the weak immune system is verified in colon cancer. The heightened expression of markers and the reduction of methylation in colon cancer promote tumor development in an extensive mechanism so that there is no biological process that can be enriched in different types.Xuepu SunYu GuoYu ZhangPeng ZhaoZhaoqing WangZheng WeiHaiquan QiaoFrontiers Media S.A.articlecolon cancersingle celltranscriptomemethylationcomprehensive analysismarker genesBiology (General)QH301-705.5ENFrontiers in Cell and Developmental Biology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	colon cancer single cell transcriptome methylation comprehensive analysis marker genes Biology (General) QH301-705.5
spellingShingle	colon cancer single cell transcriptome methylation comprehensive analysis marker genes Biology (General) QH301-705.5 Xuepu Sun Yu Guo Yu Zhang Peng Zhao Zhaoqing Wang Zheng Wei Haiquan Qiao Colon Cancer-Related Genes Identification and Function Study Based on Single-Cell Multi-Omics Integration
description	Transcriptomes and DNA methylation of colon cancer at the single-cell level are used to identify marker genes and improve diagnoses and therapies. Seven colon cancer subtypes are recognized based on the single-cell RNA sequence, and the differentially expressed genes regulated by dysregulated methylation are identified as marker genes for different types of colon cancer. Compared with normal colon cells, marker genes of different types show very obvious specificity, especially upregulated genes in tumors. Functional enrichment analysis for marker genes indicates a possible relation between colon cancer and nervous system disease, moreover, the weak immune system is verified in colon cancer. The heightened expression of markers and the reduction of methylation in colon cancer promote tumor development in an extensive mechanism so that there is no biological process that can be enriched in different types.
format	article
author	Xuepu Sun Yu Guo Yu Zhang Peng Zhao Zhaoqing Wang Zheng Wei Haiquan Qiao
author_facet	Xuepu Sun Yu Guo Yu Zhang Peng Zhao Zhaoqing Wang Zheng Wei Haiquan Qiao
author_sort	Xuepu Sun
title	Colon Cancer-Related Genes Identification and Function Study Based on Single-Cell Multi-Omics Integration
title_short	Colon Cancer-Related Genes Identification and Function Study Based on Single-Cell Multi-Omics Integration
title_full	Colon Cancer-Related Genes Identification and Function Study Based on Single-Cell Multi-Omics Integration
title_fullStr	Colon Cancer-Related Genes Identification and Function Study Based on Single-Cell Multi-Omics Integration
title_full_unstemmed	Colon Cancer-Related Genes Identification and Function Study Based on Single-Cell Multi-Omics Integration
title_sort	colon cancer-related genes identification and function study based on single-cell multi-omics integration
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/efc026ddae1b40488cf0c8cf454075f8
work_keys_str_mv	AT xuepusun coloncancerrelatedgenesidentificationandfunctionstudybasedonsinglecellmultiomicsintegration AT yuguo coloncancerrelatedgenesidentificationandfunctionstudybasedonsinglecellmultiomicsintegration AT yuzhang coloncancerrelatedgenesidentificationandfunctionstudybasedonsinglecellmultiomicsintegration AT pengzhao coloncancerrelatedgenesidentificationandfunctionstudybasedonsinglecellmultiomicsintegration AT zhaoqingwang coloncancerrelatedgenesidentificationandfunctionstudybasedonsinglecellmultiomicsintegration AT zhengwei coloncancerrelatedgenesidentificationandfunctionstudybasedonsinglecellmultiomicsintegration AT haiquanqiao coloncancerrelatedgenesidentificationandfunctionstudybasedonsinglecellmultiomicsintegration
_version_	1718405936254550016

Colon Cancer-Related Genes Identification and Function Study Based on Single-Cell Multi-Omics Integration

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