Flexible Neural Probes with Electrochemical Modified Microelectrodes for Artifact-Free Optogenetic Applications

With the rapid increase in the use of optogenetics to investigate nervous systems, there is high demand for neural interfaces that can simultaneously perform optical stimulation and electrophysiological recording. However, high-magnitude stimulation artifacts have prevented experiments from being co...

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Autores principales:	Bangbang Guo, Ye Fan, Minghao Wang, Yuhua Cheng, Bowen Ji, Ying Chen, Gaofeng Wang
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	optogenetics photoelectric artifact Pt-Black/PEDOT-GO neural recording optical stimulation Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/efc14e8170ae43f9856ee1844eece807
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id	oai:doaj.org-article:efc14e8170ae43f9856ee1844eece807
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spelling	oai:doaj.org-article:efc14e8170ae43f9856ee1844eece8072021-11-11T16:59:18ZFlexible Neural Probes with Electrochemical Modified Microelectrodes for Artifact-Free Optogenetic Applications10.3390/ijms2221115281422-00671661-6596https://doaj.org/article/efc14e8170ae43f9856ee1844eece8072021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11528https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067With the rapid increase in the use of optogenetics to investigate nervous systems, there is high demand for neural interfaces that can simultaneously perform optical stimulation and electrophysiological recording. However, high-magnitude stimulation artifacts have prevented experiments from being conducted at a desirably high temporal resolution. Here, a flexible polyimide-based neural probe with polyethylene glycol (PEG) packaged optical fiber and Pt-Black/PEDOT-GO (graphene oxide doped poly(3,4-ethylene-dioxythiophene)) modified microelectrodes was developed to reduce the stimulation artifacts that are induced by photoelectrochemical (PEC) and photovoltaic (PV) effects. The advantages of this design include quick and accurate implantation and high-resolution recording capacities. Firstly, electrochemical performance of the modified microelectrodes is significantly improved due to the large specific surface area of the GO layer. Secondly, good mechanical and electrochemical stability of the modified microelectrodes is obtained by using Pt-Black as bonding layer. Lastly, bench noise recordings revealed that PEC noise amplitude of the modified neural probes could be reduced to less than 50 µV and no PV noise was detected when compared to silicon-based neural probes. The results indicate that this device is a promising optogenetic tool for studying local neural circuits.Bangbang GuoYe FanMinghao WangYuhua ChengBowen JiYing ChenGaofeng WangMDPI AGarticleoptogeneticsphotoelectric artifactPt-Black/PEDOT-GOneural recordingoptical stimulationBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11528, p 11528 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	optogenetics photoelectric artifact Pt-Black/PEDOT-GO neural recording optical stimulation Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	optogenetics photoelectric artifact Pt-Black/PEDOT-GO neural recording optical stimulation Biology (General) QH301-705.5 Chemistry QD1-999 Bangbang Guo Ye Fan Minghao Wang Yuhua Cheng Bowen Ji Ying Chen Gaofeng Wang Flexible Neural Probes with Electrochemical Modified Microelectrodes for Artifact-Free Optogenetic Applications
description	With the rapid increase in the use of optogenetics to investigate nervous systems, there is high demand for neural interfaces that can simultaneously perform optical stimulation and electrophysiological recording. However, high-magnitude stimulation artifacts have prevented experiments from being conducted at a desirably high temporal resolution. Here, a flexible polyimide-based neural probe with polyethylene glycol (PEG) packaged optical fiber and Pt-Black/PEDOT-GO (graphene oxide doped poly(3,4-ethylene-dioxythiophene)) modified microelectrodes was developed to reduce the stimulation artifacts that are induced by photoelectrochemical (PEC) and photovoltaic (PV) effects. The advantages of this design include quick and accurate implantation and high-resolution recording capacities. Firstly, electrochemical performance of the modified microelectrodes is significantly improved due to the large specific surface area of the GO layer. Secondly, good mechanical and electrochemical stability of the modified microelectrodes is obtained by using Pt-Black as bonding layer. Lastly, bench noise recordings revealed that PEC noise amplitude of the modified neural probes could be reduced to less than 50 µV and no PV noise was detected when compared to silicon-based neural probes. The results indicate that this device is a promising optogenetic tool for studying local neural circuits.
format	article
author	Bangbang Guo Ye Fan Minghao Wang Yuhua Cheng Bowen Ji Ying Chen Gaofeng Wang
author_facet	Bangbang Guo Ye Fan Minghao Wang Yuhua Cheng Bowen Ji Ying Chen Gaofeng Wang
author_sort	Bangbang Guo
title	Flexible Neural Probes with Electrochemical Modified Microelectrodes for Artifact-Free Optogenetic Applications
title_short	Flexible Neural Probes with Electrochemical Modified Microelectrodes for Artifact-Free Optogenetic Applications
title_full	Flexible Neural Probes with Electrochemical Modified Microelectrodes for Artifact-Free Optogenetic Applications
title_fullStr	Flexible Neural Probes with Electrochemical Modified Microelectrodes for Artifact-Free Optogenetic Applications
title_full_unstemmed	Flexible Neural Probes with Electrochemical Modified Microelectrodes for Artifact-Free Optogenetic Applications
title_sort	flexible neural probes with electrochemical modified microelectrodes for artifact-free optogenetic applications
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/efc14e8170ae43f9856ee1844eece807
work_keys_str_mv	AT bangbangguo flexibleneuralprobeswithelectrochemicalmodifiedmicroelectrodesforartifactfreeoptogeneticapplications AT yefan flexibleneuralprobeswithelectrochemicalmodifiedmicroelectrodesforartifactfreeoptogeneticapplications AT minghaowang flexibleneuralprobeswithelectrochemicalmodifiedmicroelectrodesforartifactfreeoptogeneticapplications AT yuhuacheng flexibleneuralprobeswithelectrochemicalmodifiedmicroelectrodesforartifactfreeoptogeneticapplications AT bowenji flexibleneuralprobeswithelectrochemicalmodifiedmicroelectrodesforartifactfreeoptogeneticapplications AT yingchen flexibleneuralprobeswithelectrochemicalmodifiedmicroelectrodesforartifactfreeoptogeneticapplications AT gaofengwang flexibleneuralprobeswithelectrochemicalmodifiedmicroelectrodesforartifactfreeoptogeneticapplications
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Flexible Neural Probes with Electrochemical Modified Microelectrodes for Artifact-Free Optogenetic Applications

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