Ginsenoside Rg1 ameliorates cardiac oxidative stress and inflammation in streptozotocin-induced diabetic rats

Qiaoji Qin, Nan Lin, Huan Huang, Xuezhi Zhang, Xuelei Cao, Yongbin Wang, Peng LiEmergency Department, The Affiliated Hospital of Qingdao University, Qingdao 266003, Shandong, People’s Republic of ChinaBackground and purpose: Ginsenoside Rg1 (GS Rg1), as an important active substance of Pan...

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Autores principales:	Qin Q, Lin N, Huang H, Zhang X, Cao X, Wang Y, Li P
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Ginsenoside Rg1 Oxidative stress Inflammation AMPK Nrf HO-1 Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/efc66707b9904b46aa6afb688f7b2d93
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spelling	oai:doaj.org-article:efc66707b9904b46aa6afb688f7b2d932021-12-02T05:39:17ZGinsenoside Rg1 ameliorates cardiac oxidative stress and inflammation in streptozotocin-induced diabetic rats1178-7007https://doaj.org/article/efc66707b9904b46aa6afb688f7b2d932019-07-01T00:00:00Zhttps://www.dovepress.com/ginsenoside-rg1-ameliorates-cardiac-oxidative-stress-and-inflammation--peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Qiaoji Qin, Nan Lin, Huan Huang, Xuezhi Zhang, Xuelei Cao, Yongbin Wang, Peng LiEmergency Department, The Affiliated Hospital of Qingdao University, Qingdao 266003, Shandong, People’s Republic of ChinaBackground and purpose: Ginsenoside Rg1 (GS Rg1), as an important active substance of Panax ginseng, has been proven to have elaborate cardioprotective effects. The purpose of this study was to detect that GS Rg1 attenuates cardiac oxidative stress and inflammation in streptozotocin (STZ)-induced diabetic rats (DM).Methods: Cardiac function was assessed by heart rate and blood pressure. Markers relevant to myocardial oxidative stress and antioxidant capacity, and inflammatory reaction factors were detected. The mRNA and protein expression were detected by RT-qPCR and Western blot, respectively.Results: GS Rg1 treatment signiﬁcantly reduced the symptoms of cardiac hypertrophy and hypertension, and also decreased oxidative stress, inflammation response, NF-κB expression and NLRP3 inflammasome expression. GS Rg1 enhanced mitochondrial biogenesis by increasing PGC-1α, complex III and complex Ⅳ expression. GS Rg1 treatment significantly increased the expression of AMPK, Nrf2 and HO-1 in cardiac tissues.Conclusion: GS Rg1 exhibited protective effect against STZ-induced cardiac dysfunction, which is potentially associated with AMPK/Nrf2/HO-1 signal pathway.Keywords: Ginsenoside Rg1, oxidative stress, inflammation, AMPK, Nrf, HO-1Qin QLin NHuang HZhang XCao XWang YLi PDove Medical PressarticleGinsenoside Rg1Oxidative stressInflammationAMPKNrfHO-1Specialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 12, Pp 1091-1103 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ginsenoside Rg1 Oxidative stress Inflammation AMPK Nrf HO-1 Specialties of internal medicine RC581-951
spellingShingle	Ginsenoside Rg1 Oxidative stress Inflammation AMPK Nrf HO-1 Specialties of internal medicine RC581-951 Qin Q Lin N Huang H Zhang X Cao X Wang Y Li P Ginsenoside Rg1 ameliorates cardiac oxidative stress and inflammation in streptozotocin-induced diabetic rats
description	Qiaoji Qin, Nan Lin, Huan Huang, Xuezhi Zhang, Xuelei Cao, Yongbin Wang, Peng LiEmergency Department, The Affiliated Hospital of Qingdao University, Qingdao 266003, Shandong, People’s Republic of ChinaBackground and purpose: Ginsenoside Rg1 (GS Rg1), as an important active substance of Panax ginseng, has been proven to have elaborate cardioprotective effects. The purpose of this study was to detect that GS Rg1 attenuates cardiac oxidative stress and inflammation in streptozotocin (STZ)-induced diabetic rats (DM).Methods: Cardiac function was assessed by heart rate and blood pressure. Markers relevant to myocardial oxidative stress and antioxidant capacity, and inflammatory reaction factors were detected. The mRNA and protein expression were detected by RT-qPCR and Western blot, respectively.Results: GS Rg1 treatment signiﬁcantly reduced the symptoms of cardiac hypertrophy and hypertension, and also decreased oxidative stress, inflammation response, NF-κB expression and NLRP3 inflammasome expression. GS Rg1 enhanced mitochondrial biogenesis by increasing PGC-1α, complex III and complex Ⅳ expression. GS Rg1 treatment significantly increased the expression of AMPK, Nrf2 and HO-1 in cardiac tissues.Conclusion: GS Rg1 exhibited protective effect against STZ-induced cardiac dysfunction, which is potentially associated with AMPK/Nrf2/HO-1 signal pathway.Keywords: Ginsenoside Rg1, oxidative stress, inflammation, AMPK, Nrf, HO-1
format	article
author	Qin Q Lin N Huang H Zhang X Cao X Wang Y Li P
author_facet	Qin Q Lin N Huang H Zhang X Cao X Wang Y Li P
author_sort	Qin Q
title	Ginsenoside Rg1 ameliorates cardiac oxidative stress and inflammation in streptozotocin-induced diabetic rats
title_short	Ginsenoside Rg1 ameliorates cardiac oxidative stress and inflammation in streptozotocin-induced diabetic rats
title_full	Ginsenoside Rg1 ameliorates cardiac oxidative stress and inflammation in streptozotocin-induced diabetic rats
title_fullStr	Ginsenoside Rg1 ameliorates cardiac oxidative stress and inflammation in streptozotocin-induced diabetic rats
title_full_unstemmed	Ginsenoside Rg1 ameliorates cardiac oxidative stress and inflammation in streptozotocin-induced diabetic rats
title_sort	ginsenoside rg1 ameliorates cardiac oxidative stress and inflammation in streptozotocin-induced diabetic rats
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/efc66707b9904b46aa6afb688f7b2d93
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Ginsenoside Rg1 ameliorates cardiac oxidative stress and inflammation in streptozotocin-induced diabetic rats

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