Association between FGFR1OP2/wit3.0 polymorphisms and residual ridge resorption of mandible in Korean population.

<h4>Background</h4>A previous study on the genetic association between single nucleotide polymorphisms in FGFR1OP2/wit3.0 and the long term atrophy of edentulous mandible hypothesized that the excessive jawbone atrophy after dental extraction may be associated with abnormal oral mucosa c...

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Autores principales:	Jee Hwan Kim, Min Young Oh, Janghyun Paek, Jaehoon Lee
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/efc74e16acee41c78d3de3f3ccb1b66f
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spelling	oai:doaj.org-article:efc74e16acee41c78d3de3f3ccb1b66f2021-11-18T07:09:32ZAssociation between FGFR1OP2/wit3.0 polymorphisms and residual ridge resorption of mandible in Korean population.1932-620310.1371/journal.pone.0042734https://doaj.org/article/efc74e16acee41c78d3de3f3ccb1b66f2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22880093/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>A previous study on the genetic association between single nucleotide polymorphisms in FGFR1OP2/wit3.0 and the long term atrophy of edentulous mandible hypothesized that the excessive jawbone atrophy after dental extraction may be associated with abnormal oral mucosa contraction induced by the FGFR1OP2/wit 3.0 gene. It was reported that the minor allele of rs840869 or rs859024 in FGFR1OP2/wit3.0 was associated with the excessive atrophy of edentulous mandible. The present study represents an attempt to replicate the results of this previous study and to examine the genetic association between polymorphisms in FGFR1OP2 and residual ridge resorption of mandible in a Korean population.<h4>Methodology/principal findings</h4>134 subjects (70.46 ± 9.02 years) with partially or completely edentulous mandible were recruited. The mandibular bone height was measured following the protocol of the American College of Prosthodontists (ACP). From 24 subjects, seven variants in FGFR1OP2 were discovered and four of them were novel. Selected SNPs that are not in high LD at r2 threshold of 0.8 were genotyped for the remaining population. There was no frequency of the minor allele of SNP rs859024 in Korean population. SNP rs840869 was not associated with residual ridge resorption (p = 0.479). The bone height of the subject with the ss518063493 minor allele (8.52 mm) was shorter than that of those subjects with major alleles (18.96 ± 5.33 mm, p = 0.053).<h4>Conclusions/significance</h4>The patient with minor allele of ss518063493 may be associated with excessive atrophy of edentulous mandible whereas the patients with that of rs840869 are not associated in Korean population. The result from this study may assist in developing a novel genetic diagnostic test and be useful in identifying Koreans susceptible to developing excessive jawbone atrophy after dental extraction.Jee Hwan KimMin Young OhJanghyun PaekJaehoon LeePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 8, p e42734 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jee Hwan Kim Min Young Oh Janghyun Paek Jaehoon Lee Association between FGFR1OP2/wit3.0 polymorphisms and residual ridge resorption of mandible in Korean population.
description	<h4>Background</h4>A previous study on the genetic association between single nucleotide polymorphisms in FGFR1OP2/wit3.0 and the long term atrophy of edentulous mandible hypothesized that the excessive jawbone atrophy after dental extraction may be associated with abnormal oral mucosa contraction induced by the FGFR1OP2/wit 3.0 gene. It was reported that the minor allele of rs840869 or rs859024 in FGFR1OP2/wit3.0 was associated with the excessive atrophy of edentulous mandible. The present study represents an attempt to replicate the results of this previous study and to examine the genetic association between polymorphisms in FGFR1OP2 and residual ridge resorption of mandible in a Korean population.<h4>Methodology/principal findings</h4>134 subjects (70.46 ± 9.02 years) with partially or completely edentulous mandible were recruited. The mandibular bone height was measured following the protocol of the American College of Prosthodontists (ACP). From 24 subjects, seven variants in FGFR1OP2 were discovered and four of them were novel. Selected SNPs that are not in high LD at r2 threshold of 0.8 were genotyped for the remaining population. There was no frequency of the minor allele of SNP rs859024 in Korean population. SNP rs840869 was not associated with residual ridge resorption (p = 0.479). The bone height of the subject with the ss518063493 minor allele (8.52 mm) was shorter than that of those subjects with major alleles (18.96 ± 5.33 mm, p = 0.053).<h4>Conclusions/significance</h4>The patient with minor allele of ss518063493 may be associated with excessive atrophy of edentulous mandible whereas the patients with that of rs840869 are not associated in Korean population. The result from this study may assist in developing a novel genetic diagnostic test and be useful in identifying Koreans susceptible to developing excessive jawbone atrophy after dental extraction.
format	article
author	Jee Hwan Kim Min Young Oh Janghyun Paek Jaehoon Lee
author_facet	Jee Hwan Kim Min Young Oh Janghyun Paek Jaehoon Lee
author_sort	Jee Hwan Kim
title	Association between FGFR1OP2/wit3.0 polymorphisms and residual ridge resorption of mandible in Korean population.
title_short	Association between FGFR1OP2/wit3.0 polymorphisms and residual ridge resorption of mandible in Korean population.
title_full	Association between FGFR1OP2/wit3.0 polymorphisms and residual ridge resorption of mandible in Korean population.
title_fullStr	Association between FGFR1OP2/wit3.0 polymorphisms and residual ridge resorption of mandible in Korean population.
title_full_unstemmed	Association between FGFR1OP2/wit3.0 polymorphisms and residual ridge resorption of mandible in Korean population.
title_sort	association between fgfr1op2/wit3.0 polymorphisms and residual ridge resorption of mandible in korean population.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/efc74e16acee41c78d3de3f3ccb1b66f
work_keys_str_mv	AT jeehwankim associationbetweenfgfr1op2wit30polymorphismsandresidualridgeresorptionofmandibleinkoreanpopulation AT minyoungoh associationbetweenfgfr1op2wit30polymorphismsandresidualridgeresorptionofmandibleinkoreanpopulation AT janghyunpaek associationbetweenfgfr1op2wit30polymorphismsandresidualridgeresorptionofmandibleinkoreanpopulation AT jaehoonlee associationbetweenfgfr1op2wit30polymorphismsandresidualridgeresorptionofmandibleinkoreanpopulation
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Association between FGFR1OP2/wit3.0 polymorphisms and residual ridge resorption of mandible in Korean population.

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