CRISPR-Associated Primase-Polymerases are implicated in prokaryotic CRISPR-Cas adaptation

CAPPs are putative Primase-Polymerases associated with CRISPR-Cas operons. Here, the authors show CAPPs genetic and physical association with Cas1 and Cas2, their capacity to function as DNA-dependent DNA primases and DNA polymerases, and that Cas1-Cas2 complex adjacent to CAPP has bona fide spacer...

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Autores principales:	Katerina Zabrady, Matej Zabrady, Peter Kolesar, Arthur W. H. Li, Aidan J. Doherty
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/efc9c689cc494105b57df2aab55a9b23
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spelling	oai:doaj.org-article:efc9c689cc494105b57df2aab55a9b232021-12-02T17:40:24ZCRISPR-Associated Primase-Polymerases are implicated in prokaryotic CRISPR-Cas adaptation10.1038/s41467-021-23535-92041-1723https://doaj.org/article/efc9c689cc494105b57df2aab55a9b232021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23535-9https://doaj.org/toc/2041-1723CAPPs are putative Primase-Polymerases associated with CRISPR-Cas operons. Here, the authors show CAPPs genetic and physical association with Cas1 and Cas2, their capacity to function as DNA-dependent DNA primases and DNA polymerases, and that Cas1-Cas2 complex adjacent to CAPP has bona fide spacer integration activity.Katerina ZabradyMatej ZabradyPeter KolesarArthur W. H. LiAidan J. DohertyNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Katerina Zabrady Matej Zabrady Peter Kolesar Arthur W. H. Li Aidan J. Doherty CRISPR-Associated Primase-Polymerases are implicated in prokaryotic CRISPR-Cas adaptation
description	CAPPs are putative Primase-Polymerases associated with CRISPR-Cas operons. Here, the authors show CAPPs genetic and physical association with Cas1 and Cas2, their capacity to function as DNA-dependent DNA primases and DNA polymerases, and that Cas1-Cas2 complex adjacent to CAPP has bona fide spacer integration activity.
format	article
author	Katerina Zabrady Matej Zabrady Peter Kolesar Arthur W. H. Li Aidan J. Doherty
author_facet	Katerina Zabrady Matej Zabrady Peter Kolesar Arthur W. H. Li Aidan J. Doherty
author_sort	Katerina Zabrady
title	CRISPR-Associated Primase-Polymerases are implicated in prokaryotic CRISPR-Cas adaptation
title_short	CRISPR-Associated Primase-Polymerases are implicated in prokaryotic CRISPR-Cas adaptation
title_full	CRISPR-Associated Primase-Polymerases are implicated in prokaryotic CRISPR-Cas adaptation
title_fullStr	CRISPR-Associated Primase-Polymerases are implicated in prokaryotic CRISPR-Cas adaptation
title_full_unstemmed	CRISPR-Associated Primase-Polymerases are implicated in prokaryotic CRISPR-Cas adaptation
title_sort	crispr-associated primase-polymerases are implicated in prokaryotic crispr-cas adaptation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/efc9c689cc494105b57df2aab55a9b23
work_keys_str_mv	AT katerinazabrady crisprassociatedprimasepolymerasesareimplicatedinprokaryoticcrisprcasadaptation AT matejzabrady crisprassociatedprimasepolymerasesareimplicatedinprokaryoticcrisprcasadaptation AT peterkolesar crisprassociatedprimasepolymerasesareimplicatedinprokaryoticcrisprcasadaptation AT arthurwhli crisprassociatedprimasepolymerasesareimplicatedinprokaryoticcrisprcasadaptation AT aidanjdoherty crisprassociatedprimasepolymerasesareimplicatedinprokaryoticcrisprcasadaptation
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CRISPR-Associated Primase-Polymerases are implicated in prokaryotic CRISPR-Cas adaptation

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