Platelets reduce anoikis and promote metastasis by activating YAP1 signaling

Platelets have been associated with increased tumor growth and metastasis but the mechanistic details of this interaction are still unclear. Here the authors show that platelets improve anoikis resistance of cancer cells and increase metastasis by activating Yap through a RhoA/MYPT-PP1 pathway.

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Autores principales:	Monika Haemmerle, Morgan L. Taylor, Tony Gutschner, Sunila Pradeep, Min Soon Cho, Jianting Sheng, Yasmin M. Lyons, Archana S. Nagaraja, Robert L. Dood, Yunfei Wen, Lingegowda S. Mangala, Jean M. Hansen, Rajesha Rupaimoole, Kshipra M. Gharpure, Cristian Rodriguez-Aguayo, Sun Young Yim, Ju-Seog Lee, Cristina Ivan, Wei Hu, Gabriel Lopez-Berestein, Stephen T. Wong, Beth Y. Karlan, Douglas A. Levine, Jinsong Liu, Vahid Afshar-Kharghan, Anil K. Sood
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/efca299554474b9dba711b2ea7a0c35f
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spelling	oai:doaj.org-article:efca299554474b9dba711b2ea7a0c35f2021-12-02T13:24:23ZPlatelets reduce anoikis and promote metastasis by activating YAP1 signaling10.1038/s41467-017-00411-z2041-1723https://doaj.org/article/efca299554474b9dba711b2ea7a0c35f2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00411-zhttps://doaj.org/toc/2041-1723Platelets have been associated with increased tumor growth and metastasis but the mechanistic details of this interaction are still unclear. Here the authors show that platelets improve anoikis resistance of cancer cells and increase metastasis by activating Yap through a RhoA/MYPT-PP1 pathway.Monika HaemmerleMorgan L. TaylorTony GutschnerSunila PradeepMin Soon ChoJianting ShengYasmin M. LyonsArchana S. NagarajaRobert L. DoodYunfei WenLingegowda S. MangalaJean M. HansenRajesha RupaimooleKshipra M. GharpureCristian Rodriguez-AguayoSun Young YimJu-Seog LeeCristina IvanWei HuGabriel Lopez-BeresteinStephen T. WongBeth Y. KarlanDouglas A. LevineJinsong LiuVahid Afshar-KharghanAnil K. SoodNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Monika Haemmerle Morgan L. Taylor Tony Gutschner Sunila Pradeep Min Soon Cho Jianting Sheng Yasmin M. Lyons Archana S. Nagaraja Robert L. Dood Yunfei Wen Lingegowda S. Mangala Jean M. Hansen Rajesha Rupaimoole Kshipra M. Gharpure Cristian Rodriguez-Aguayo Sun Young Yim Ju-Seog Lee Cristina Ivan Wei Hu Gabriel Lopez-Berestein Stephen T. Wong Beth Y. Karlan Douglas A. Levine Jinsong Liu Vahid Afshar-Kharghan Anil K. Sood Platelets reduce anoikis and promote metastasis by activating YAP1 signaling
description	Platelets have been associated with increased tumor growth and metastasis but the mechanistic details of this interaction are still unclear. Here the authors show that platelets improve anoikis resistance of cancer cells and increase metastasis by activating Yap through a RhoA/MYPT-PP1 pathway.
format	article
author	Monika Haemmerle Morgan L. Taylor Tony Gutschner Sunila Pradeep Min Soon Cho Jianting Sheng Yasmin M. Lyons Archana S. Nagaraja Robert L. Dood Yunfei Wen Lingegowda S. Mangala Jean M. Hansen Rajesha Rupaimoole Kshipra M. Gharpure Cristian Rodriguez-Aguayo Sun Young Yim Ju-Seog Lee Cristina Ivan Wei Hu Gabriel Lopez-Berestein Stephen T. Wong Beth Y. Karlan Douglas A. Levine Jinsong Liu Vahid Afshar-Kharghan Anil K. Sood
author_facet	Monika Haemmerle Morgan L. Taylor Tony Gutschner Sunila Pradeep Min Soon Cho Jianting Sheng Yasmin M. Lyons Archana S. Nagaraja Robert L. Dood Yunfei Wen Lingegowda S. Mangala Jean M. Hansen Rajesha Rupaimoole Kshipra M. Gharpure Cristian Rodriguez-Aguayo Sun Young Yim Ju-Seog Lee Cristina Ivan Wei Hu Gabriel Lopez-Berestein Stephen T. Wong Beth Y. Karlan Douglas A. Levine Jinsong Liu Vahid Afshar-Kharghan Anil K. Sood
author_sort	Monika Haemmerle
title	Platelets reduce anoikis and promote metastasis by activating YAP1 signaling
title_short	Platelets reduce anoikis and promote metastasis by activating YAP1 signaling
title_full	Platelets reduce anoikis and promote metastasis by activating YAP1 signaling
title_fullStr	Platelets reduce anoikis and promote metastasis by activating YAP1 signaling
title_full_unstemmed	Platelets reduce anoikis and promote metastasis by activating YAP1 signaling
title_sort	platelets reduce anoikis and promote metastasis by activating yap1 signaling
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/efca299554474b9dba711b2ea7a0c35f
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Platelets reduce anoikis and promote metastasis by activating YAP1 signaling

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