Facile access to C-glycosyl amino acids and peptides via Ni-catalyzed reductive hydroglycosylation of alkynes

C-Glycosyl peptides/proteins are metabolically stable mimics of the native glycopeptides/proteins of great therapeutic potential, but their chemical synthesis is challenging. Here, the authors report a protocol for the synthesis of vinyl C-glycosyl amino acids and peptides, via a Ni-catalyzed reduct...

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Autores principales:	Yan-Hua Liu, Yu-Nong Xia, Tayyab Gulzar, Bingcheng Wei, Haotian Li, Dapeng Zhu, Zhifei Hu, Peng Xu, Biao Yu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/efcbfbbc3ee54b9096ca86a19866042e
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spelling	oai:doaj.org-article:efcbfbbc3ee54b9096ca86a19866042e2021-12-02T15:07:48ZFacile access to C-glycosyl amino acids and peptides via Ni-catalyzed reductive hydroglycosylation of alkynes10.1038/s41467-021-25127-z2041-1723https://doaj.org/article/efcbfbbc3ee54b9096ca86a19866042e2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25127-zhttps://doaj.org/toc/2041-1723C-Glycosyl peptides/proteins are metabolically stable mimics of the native glycopeptides/proteins of great therapeutic potential, but their chemical synthesis is challenging. Here, the authors report a protocol for the synthesis of vinyl C-glycosyl amino acids and peptides, via a Ni-catalyzed reductive hydroglycosylation reaction of alkyne derivatives of amino acids and peptides with glycosyl bromides.Yan-Hua LiuYu-Nong XiaTayyab GulzarBingcheng WeiHaotian LiDapeng ZhuZhifei HuPeng XuBiao YuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yan-Hua Liu Yu-Nong Xia Tayyab Gulzar Bingcheng Wei Haotian Li Dapeng Zhu Zhifei Hu Peng Xu Biao Yu Facile access to C-glycosyl amino acids and peptides via Ni-catalyzed reductive hydroglycosylation of alkynes
description	C-Glycosyl peptides/proteins are metabolically stable mimics of the native glycopeptides/proteins of great therapeutic potential, but their chemical synthesis is challenging. Here, the authors report a protocol for the synthesis of vinyl C-glycosyl amino acids and peptides, via a Ni-catalyzed reductive hydroglycosylation reaction of alkyne derivatives of amino acids and peptides with glycosyl bromides.
format	article
author	Yan-Hua Liu Yu-Nong Xia Tayyab Gulzar Bingcheng Wei Haotian Li Dapeng Zhu Zhifei Hu Peng Xu Biao Yu
author_facet	Yan-Hua Liu Yu-Nong Xia Tayyab Gulzar Bingcheng Wei Haotian Li Dapeng Zhu Zhifei Hu Peng Xu Biao Yu
author_sort	Yan-Hua Liu
title	Facile access to C-glycosyl amino acids and peptides via Ni-catalyzed reductive hydroglycosylation of alkynes
title_short	Facile access to C-glycosyl amino acids and peptides via Ni-catalyzed reductive hydroglycosylation of alkynes
title_full	Facile access to C-glycosyl amino acids and peptides via Ni-catalyzed reductive hydroglycosylation of alkynes
title_fullStr	Facile access to C-glycosyl amino acids and peptides via Ni-catalyzed reductive hydroglycosylation of alkynes
title_full_unstemmed	Facile access to C-glycosyl amino acids and peptides via Ni-catalyzed reductive hydroglycosylation of alkynes
title_sort	facile access to c-glycosyl amino acids and peptides via ni-catalyzed reductive hydroglycosylation of alkynes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/efcbfbbc3ee54b9096ca86a19866042e
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Facile access to C-glycosyl amino acids and peptides via Ni-catalyzed reductive hydroglycosylation of alkynes

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