Vascular Endothelial Growth Factor in Unstimulated Saliva of the Patients with Minor Aphtha

BACKGROUND AND OBJECTIVE: Vascular endothelial growth factor (VEGF) is a heterodimeric glycoprotein that stimulates angiogenesis and plays a role in ulcer healing. The pathogenesis of the aphtha is unknown and few studies have been undertaken on the subject and have reported conflicting results. The...

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Autores principales:	S Seifi, M Motallebnejad, GH Maliji, A Bijani, S Farnia
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2012
Materias:	vascular endothelial growth factor saliva aphthous ulcer Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/efd12778fff346acbb05e6d1bd676905
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spelling	oai:doaj.org-article:efd12778fff346acbb05e6d1bd6769052021-11-10T08:53:26ZVascular Endothelial Growth Factor in Unstimulated Saliva of the Patients with Minor Aphtha1561-41072251-7170https://doaj.org/article/efd12778fff346acbb05e6d1bd6769052012-09-01T00:00:00Zhttp://jbums.org/article-1-4182-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND AND OBJECTIVE: Vascular endothelial growth factor (VEGF) is a heterodimeric glycoprotein that stimulates angiogenesis and plays a role in ulcer healing. The pathogenesis of the aphtha is unknown and few studies have been undertaken on the subject and have reported conflicting results. The present study aimed to determine the level and role of VEGF in four clinical stages and pathogenesis of the minor aphtha.METHODS: In this case-control study, unstimulated saliva of the 18 patients with minor aphtha in four clinical stages (prodromal, preulcerous, ulcerative and healing) and 18 persons of control group, by asking them to spit their saliva was collected. Saliva VEGF (pg/ml) level were assessed using ELISA method. The results were compared with each other and with control group.FINDINGS: Saliva VEGF level (pg/ml) in prodromal, preulcerous, ulcerative and healing stages was 21.32±12.94, 14.5±11.1, 10.49±9.46 and 13.26±12.06, respectively, and in control group was 20.15±57.83 pg/ml. Statistically significant differences in clinical aphtha (4 stages) were seen (p=0.002). The lowest VEGF level was observed in ulcerative stage in comparison to control group (p= 0.02). VEGF level in prodromal stage was higher than ulcerative (p=0.006) and healing stages (p=0.014), but no significant VEGF difference was observed between healing and ulcerative stages (p=0.158), healing and preulcerous stages (p=0.619) or prodromal and preulcerous stages. (p=0.066)CONCLUSION: According to the results of this study, the changes in VEGF level especially its decrease in ulcerative stage have a role in the pathogenesis of the formation of minor aphthous ulcer but the minor aphtha is not resulted from high angiogenesis.S Seifi,M Motallebnejad,GH Maliji,A Bijani,S FarniaBabol University of Medical Sciencesarticlevascular endothelial growth factorsalivaaphthous ulcerMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 14, Iss 5, Pp 64-69 (2012)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	vascular endothelial growth factor saliva aphthous ulcer Medicine R Medicine (General) R5-920
spellingShingle	vascular endothelial growth factor saliva aphthous ulcer Medicine R Medicine (General) R5-920 S Seifi, M Motallebnejad, GH Maliji, A Bijani, S Farnia Vascular Endothelial Growth Factor in Unstimulated Saliva of the Patients with Minor Aphtha
description	BACKGROUND AND OBJECTIVE: Vascular endothelial growth factor (VEGF) is a heterodimeric glycoprotein that stimulates angiogenesis and plays a role in ulcer healing. The pathogenesis of the aphtha is unknown and few studies have been undertaken on the subject and have reported conflicting results. The present study aimed to determine the level and role of VEGF in four clinical stages and pathogenesis of the minor aphtha.METHODS: In this case-control study, unstimulated saliva of the 18 patients with minor aphtha in four clinical stages (prodromal, preulcerous, ulcerative and healing) and 18 persons of control group, by asking them to spit their saliva was collected. Saliva VEGF (pg/ml) level were assessed using ELISA method. The results were compared with each other and with control group.FINDINGS: Saliva VEGF level (pg/ml) in prodromal, preulcerous, ulcerative and healing stages was 21.32±12.94, 14.5±11.1, 10.49±9.46 and 13.26±12.06, respectively, and in control group was 20.15±57.83 pg/ml. Statistically significant differences in clinical aphtha (4 stages) were seen (p=0.002). The lowest VEGF level was observed in ulcerative stage in comparison to control group (p= 0.02). VEGF level in prodromal stage was higher than ulcerative (p=0.006) and healing stages (p=0.014), but no significant VEGF difference was observed between healing and ulcerative stages (p=0.158), healing and preulcerous stages (p=0.619) or prodromal and preulcerous stages. (p=0.066)CONCLUSION: According to the results of this study, the changes in VEGF level especially its decrease in ulcerative stage have a role in the pathogenesis of the formation of minor aphthous ulcer but the minor aphtha is not resulted from high angiogenesis.
format	article
author	S Seifi, M Motallebnejad, GH Maliji, A Bijani, S Farnia
author_facet	S Seifi, M Motallebnejad, GH Maliji, A Bijani, S Farnia
author_sort	S Seifi,
title	Vascular Endothelial Growth Factor in Unstimulated Saliva of the Patients with Minor Aphtha
title_short	Vascular Endothelial Growth Factor in Unstimulated Saliva of the Patients with Minor Aphtha
title_full	Vascular Endothelial Growth Factor in Unstimulated Saliva of the Patients with Minor Aphtha
title_fullStr	Vascular Endothelial Growth Factor in Unstimulated Saliva of the Patients with Minor Aphtha
title_full_unstemmed	Vascular Endothelial Growth Factor in Unstimulated Saliva of the Patients with Minor Aphtha
title_sort	vascular endothelial growth factor in unstimulated saliva of the patients with minor aphtha
publisher	Babol University of Medical Sciences
publishDate	2012
url	https://doaj.org/article/efd12778fff346acbb05e6d1bd676905
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Vascular Endothelial Growth Factor in Unstimulated Saliva of the Patients with Minor Aphtha

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