Airway Basal Cells, Protectors of Epithelial Walls in Health and Respiratory Diseases

The airway epithelium provides a critical barrier to the outside environment. When its integrity is impaired, epithelial cells and residing immune cells collaborate to exclude pathogens and to heal tissue damage. Healing is achieved through tissue-specific stem cells: the airway basal cells. Positio...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Emma Ruysseveldt, Katleen Martens, Brecht Steelant
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	airways basal cells epigenetics immune crosstalk tissue repair respiratory epithelium Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/efd2aaaf01634d62838a141513c8a1f5
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:efd2aaaf01634d62838a141513c8a1f5
record_format	dspace
spelling	oai:doaj.org-article:efd2aaaf01634d62838a141513c8a1f52021-11-19T05:01:43ZAirway Basal Cells, Protectors of Epithelial Walls in Health and Respiratory Diseases2673-610110.3389/falgy.2021.787128https://doaj.org/article/efd2aaaf01634d62838a141513c8a1f52021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/falgy.2021.787128/fullhttps://doaj.org/toc/2673-6101The airway epithelium provides a critical barrier to the outside environment. When its integrity is impaired, epithelial cells and residing immune cells collaborate to exclude pathogens and to heal tissue damage. Healing is achieved through tissue-specific stem cells: the airway basal cells. Positioned near the basal membrane, airway basal cells sense and respond to changes in tissue health by initiating a pro-inflammatory response and tissue repair via complex crosstalks with nearby fibroblasts and specialized immune cells. In addition, basal cells have the capacity to learn from previous encounters with the environment. Inflammation can indeed imprint a certain memory on basal cells by epigenetic changes so that sensitized tissues may respond differently to future assaults and the epithelium becomes better equipped to respond faster and more robustly to barrier defects. This memory can, however, be lost in diseased states. In this review, we discuss airway basal cells in respiratory diseases, the communication network between airway basal cells and tissue-resident and/or recruited immune cells, and how basal cell adaptation to environmental triggers occurs.Emma RuysseveldtKatleen MartensKatleen MartensBrecht SteelantBrecht SteelantFrontiers Media S.A.articleairwaysbasal cellsepigeneticsimmune crosstalktissue repairrespiratory epitheliumImmunologic diseases. AllergyRC581-607ENFrontiers in Allergy, Vol 2 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	airways basal cells epigenetics immune crosstalk tissue repair respiratory epithelium Immunologic diseases. Allergy RC581-607
spellingShingle	airways basal cells epigenetics immune crosstalk tissue repair respiratory epithelium Immunologic diseases. Allergy RC581-607 Emma Ruysseveldt Katleen Martens Katleen Martens Brecht Steelant Brecht Steelant Airway Basal Cells, Protectors of Epithelial Walls in Health and Respiratory Diseases
description	The airway epithelium provides a critical barrier to the outside environment. When its integrity is impaired, epithelial cells and residing immune cells collaborate to exclude pathogens and to heal tissue damage. Healing is achieved through tissue-specific stem cells: the airway basal cells. Positioned near the basal membrane, airway basal cells sense and respond to changes in tissue health by initiating a pro-inflammatory response and tissue repair via complex crosstalks with nearby fibroblasts and specialized immune cells. In addition, basal cells have the capacity to learn from previous encounters with the environment. Inflammation can indeed imprint a certain memory on basal cells by epigenetic changes so that sensitized tissues may respond differently to future assaults and the epithelium becomes better equipped to respond faster and more robustly to barrier defects. This memory can, however, be lost in diseased states. In this review, we discuss airway basal cells in respiratory diseases, the communication network between airway basal cells and tissue-resident and/or recruited immune cells, and how basal cell adaptation to environmental triggers occurs.
format	article
author	Emma Ruysseveldt Katleen Martens Katleen Martens Brecht Steelant Brecht Steelant
author_facet	Emma Ruysseveldt Katleen Martens Katleen Martens Brecht Steelant Brecht Steelant
author_sort	Emma Ruysseveldt
title	Airway Basal Cells, Protectors of Epithelial Walls in Health and Respiratory Diseases
title_short	Airway Basal Cells, Protectors of Epithelial Walls in Health and Respiratory Diseases
title_full	Airway Basal Cells, Protectors of Epithelial Walls in Health and Respiratory Diseases
title_fullStr	Airway Basal Cells, Protectors of Epithelial Walls in Health and Respiratory Diseases
title_full_unstemmed	Airway Basal Cells, Protectors of Epithelial Walls in Health and Respiratory Diseases
title_sort	airway basal cells, protectors of epithelial walls in health and respiratory diseases
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/efd2aaaf01634d62838a141513c8a1f5
work_keys_str_mv	AT emmaruysseveldt airwaybasalcellsprotectorsofepithelialwallsinhealthandrespiratorydiseases AT katleenmartens airwaybasalcellsprotectorsofepithelialwallsinhealthandrespiratorydiseases AT katleenmartens airwaybasalcellsprotectorsofepithelialwallsinhealthandrespiratorydiseases AT brechtsteelant airwaybasalcellsprotectorsofepithelialwallsinhealthandrespiratorydiseases AT brechtsteelant airwaybasalcellsprotectorsofepithelialwallsinhealthandrespiratorydiseases
_version_	1718420409020317696

Airway Basal Cells, Protectors of Epithelial Walls in Health and Respiratory Diseases

Ejemplares similares