A Novel Alloy Development Approach: Biomedical Equiatomic Ta-Nb-Ti Alloy

In the present manuscript, we report on the properties of an equiatomic Ta-Nb-Ti alloy as the basis for a novel, biomedical, multi-component alloy development. The alloy was produced using an arc melting furnace under Ar atmosphere, metallographically prepared, and investigated respectively. Further...

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Autores principales:	Maximilian Regenberg, Janett Schmelzer, Georg Hasemann, Jessica Bertrand, Manja Krüger
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	high-entropy alloys refractory elements biocompatibility biomedical materials cell cultivation Mining engineering. Metallurgy TN1-997
Acceso en línea:	https://doaj.org/article/efd2d2dcde5c45c7bbe4ee9de4b301ba
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spelling	oai:doaj.org-article:efd2d2dcde5c45c7bbe4ee9de4b301ba2021-11-25T18:21:52ZA Novel Alloy Development Approach: Biomedical Equiatomic Ta-Nb-Ti Alloy10.3390/met111117782075-4701https://doaj.org/article/efd2d2dcde5c45c7bbe4ee9de4b301ba2021-11-01T00:00:00Zhttps://www.mdpi.com/2075-4701/11/11/1778https://doaj.org/toc/2075-4701In the present manuscript, we report on the properties of an equiatomic Ta-Nb-Ti alloy as the basis for a novel, biomedical, multi-component alloy development. The alloy was produced using an arc melting furnace under Ar atmosphere, metallographically prepared, and investigated respectively. Furthermore, the alloy produced, as well as samples of elemental Ta, Nb, alloy Co-28Cr-6Mo, and alloy Ti-6Al-4V, were prepared with defined 1200 grit SiC grinding paper. The topography of the surfaces was evaluated using confocal microscopy and contact angle measurements subsequently. Afterwards, the biocompatibility of the novel alloy Ta-Nb-Ti was evaluated by means of cell (osteoblast) attachment as well as monocyte inflammatory response analysis. First results indicate competitive osteoblast attachment, as well as comparable expressions of fibrosis markers in comparison to conventionally used biomedical materials. In addition, the Ta-Nb-Ti alloy showed a markedly reduced inflammatory capacity, indicating a high potential for use as a prospective biomedical material.Maximilian RegenbergJanett SchmelzerGeorg HasemannJessica BertrandManja KrügerMDPI AGarticlehigh-entropy alloysrefractory elementsbiocompatibilitybiomedical materialscell cultivationMining engineering. MetallurgyTN1-997ENMetals, Vol 11, Iss 1778, p 1778 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	high-entropy alloys refractory elements biocompatibility biomedical materials cell cultivation Mining engineering. Metallurgy TN1-997
spellingShingle	high-entropy alloys refractory elements biocompatibility biomedical materials cell cultivation Mining engineering. Metallurgy TN1-997 Maximilian Regenberg Janett Schmelzer Georg Hasemann Jessica Bertrand Manja Krüger A Novel Alloy Development Approach: Biomedical Equiatomic Ta-Nb-Ti Alloy
description	In the present manuscript, we report on the properties of an equiatomic Ta-Nb-Ti alloy as the basis for a novel, biomedical, multi-component alloy development. The alloy was produced using an arc melting furnace under Ar atmosphere, metallographically prepared, and investigated respectively. Furthermore, the alloy produced, as well as samples of elemental Ta, Nb, alloy Co-28Cr-6Mo, and alloy Ti-6Al-4V, were prepared with defined 1200 grit SiC grinding paper. The topography of the surfaces was evaluated using confocal microscopy and contact angle measurements subsequently. Afterwards, the biocompatibility of the novel alloy Ta-Nb-Ti was evaluated by means of cell (osteoblast) attachment as well as monocyte inflammatory response analysis. First results indicate competitive osteoblast attachment, as well as comparable expressions of fibrosis markers in comparison to conventionally used biomedical materials. In addition, the Ta-Nb-Ti alloy showed a markedly reduced inflammatory capacity, indicating a high potential for use as a prospective biomedical material.
format	article
author	Maximilian Regenberg Janett Schmelzer Georg Hasemann Jessica Bertrand Manja Krüger
author_facet	Maximilian Regenberg Janett Schmelzer Georg Hasemann Jessica Bertrand Manja Krüger
author_sort	Maximilian Regenberg
title	A Novel Alloy Development Approach: Biomedical Equiatomic Ta-Nb-Ti Alloy
title_short	A Novel Alloy Development Approach: Biomedical Equiatomic Ta-Nb-Ti Alloy
title_full	A Novel Alloy Development Approach: Biomedical Equiatomic Ta-Nb-Ti Alloy
title_fullStr	A Novel Alloy Development Approach: Biomedical Equiatomic Ta-Nb-Ti Alloy
title_full_unstemmed	A Novel Alloy Development Approach: Biomedical Equiatomic Ta-Nb-Ti Alloy
title_sort	novel alloy development approach: biomedical equiatomic ta-nb-ti alloy
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/efd2d2dcde5c45c7bbe4ee9de4b301ba
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A Novel Alloy Development Approach: Biomedical Equiatomic Ta-Nb-Ti Alloy

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