Inductive interactions mediated by interplay of asymmetric signalling underlie development of adult haematopoietic stem cells
It is unclear how the microenvironment of the aorta-gonad-mesonephros influences haematopoietic stem cell (HSC) production early in mouse development. Here, Souilhol et al. use an in vitroaggregate system as a tool to understand how several pathways, BMP, SCF and Shh, may regulate HSC production.
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| Autores principales: | , , , , , , , , , , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2016
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/efd4191028d64fedbaefeee46e52bec3 |
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| Sumario: | It is unclear how the microenvironment of the aorta-gonad-mesonephros influences haematopoietic stem cell (HSC) production early in mouse development. Here, Souilhol et al. use an in vitroaggregate system as a tool to understand how several pathways, BMP, SCF and Shh, may regulate HSC production. |
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