Inductive interactions mediated by interplay of asymmetric signalling underlie development of adult haematopoietic stem cells

It is unclear how the microenvironment of the aorta-gonad-mesonephros influences haematopoietic stem cell (HSC) production early in mouse development. Here, Souilhol et al. use an in vitroaggregate system as a tool to understand how several pathways, BMP, SCF and Shh, may regulate HSC production.

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Main Authors:	Céline Souilhol, Christèle Gonneau, Javier G. Lendinez, Antoniana Batsivari, Stanislav Rybtsov, Heather Wilson, Lucia Morgado-Palacin, David Hills, Samir Taoudi, Jennifer Antonchuk, Suling Zhao, Alexander Medvinsky
Format:	article
Language:	EN
Published:	Nature Portfolio 2016
Subjects:	Science Q
Online Access:	https://doaj.org/article/efd4191028d64fedbaefeee46e52bec3
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spelling	oai:doaj.org-article:efd4191028d64fedbaefeee46e52bec32021-12-02T14:38:33ZInductive interactions mediated by interplay of asymmetric signalling underlie development of adult haematopoietic stem cells10.1038/ncomms107842041-1723https://doaj.org/article/efd4191028d64fedbaefeee46e52bec32016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms10784https://doaj.org/toc/2041-1723It is unclear how the microenvironment of the aorta-gonad-mesonephros influences haematopoietic stem cell (HSC) production early in mouse development. Here, Souilhol et al. use an in vitroaggregate system as a tool to understand how several pathways, BMP, SCF and Shh, may regulate HSC production.Céline SouilholChristèle GonneauJavier G. LendinezAntoniana BatsivariStanislav RybtsovHeather WilsonLucia Morgado-PalacinDavid HillsSamir TaoudiJennifer AntonchukSuling ZhaoAlexander MedvinskyNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Céline Souilhol Christèle Gonneau Javier G. Lendinez Antoniana Batsivari Stanislav Rybtsov Heather Wilson Lucia Morgado-Palacin David Hills Samir Taoudi Jennifer Antonchuk Suling Zhao Alexander Medvinsky Inductive interactions mediated by interplay of asymmetric signalling underlie development of adult haematopoietic stem cells
description	It is unclear how the microenvironment of the aorta-gonad-mesonephros influences haematopoietic stem cell (HSC) production early in mouse development. Here, Souilhol et al. use an in vitroaggregate system as a tool to understand how several pathways, BMP, SCF and Shh, may regulate HSC production.
format	article
author	Céline Souilhol Christèle Gonneau Javier G. Lendinez Antoniana Batsivari Stanislav Rybtsov Heather Wilson Lucia Morgado-Palacin David Hills Samir Taoudi Jennifer Antonchuk Suling Zhao Alexander Medvinsky
author_facet	Céline Souilhol Christèle Gonneau Javier G. Lendinez Antoniana Batsivari Stanislav Rybtsov Heather Wilson Lucia Morgado-Palacin David Hills Samir Taoudi Jennifer Antonchuk Suling Zhao Alexander Medvinsky
author_sort	Céline Souilhol
title	Inductive interactions mediated by interplay of asymmetric signalling underlie development of adult haematopoietic stem cells
title_short	Inductive interactions mediated by interplay of asymmetric signalling underlie development of adult haematopoietic stem cells
title_full	Inductive interactions mediated by interplay of asymmetric signalling underlie development of adult haematopoietic stem cells
title_fullStr	Inductive interactions mediated by interplay of asymmetric signalling underlie development of adult haematopoietic stem cells
title_full_unstemmed	Inductive interactions mediated by interplay of asymmetric signalling underlie development of adult haematopoietic stem cells
title_sort	inductive interactions mediated by interplay of asymmetric signalling underlie development of adult haematopoietic stem cells
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/efd4191028d64fedbaefeee46e52bec3
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Inductive interactions mediated by interplay of asymmetric signalling underlie development of adult haematopoietic stem cells

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