HIF1α inhibition facilitates Leflunomide-AHR-CRP signaling to attenuate bone erosion in CRP-aberrant rheumatoid arthritis

HIF1α inhibition facilitates Leflunomide-AHR-CRP signaling to attenuate bone erosion in CRP-aberrant rheumatoid arthritis

Leflunomide is used for the treatment of rheumatoid arthritis. Here, the authors show that effectiveness is limited in patients with higher levels of serum c-reactive protein (CRP). Using animal models, they show that higher CRP induces HIF1a expression, which in turn interferes with Leflunomide sig...

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Autores principales: Chao Liang, Jie Li, Cheng Lu, Duoli Xie, Jin Liu, Chuanxin Zhong, Xiaohao Wu, Rongchen Dai, Huarui Zhang, Daogang Guan, Baosheng Guo, Bing He, Fangfei Li, Xiaojuan He, Wandong Zhang, Bao-Ting Zhang, Ge Zhang, Aiping Lu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/efd52d5facbd414982f94122c9661d92
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spelling oai:doaj.org-article:efd52d5facbd414982f94122c9661d922021-12-02T16:57:09ZHIF1α inhibition facilitates Leflunomide-AHR-CRP signaling to attenuate bone erosion in CRP-aberrant rheumatoid arthritis10.1038/s41467-019-12163-z2041-1723https://doaj.org/article/efd52d5facbd414982f94122c9661d922019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12163-zhttps://doaj.org/toc/2041-1723Leflunomide is used for the treatment of rheumatoid arthritis. Here, the authors show that effectiveness is limited in patients with higher levels of serum c-reactive protein (CRP). Using animal models, they show that higher CRP induces HIF1a expression, which in turn interferes with Leflunomide signalling, and that effectiveness of the drug is restored when HIF1a is pharmacologically inhibited.Chao LiangJie LiCheng LuDuoli XieJin LiuChuanxin ZhongXiaohao WuRongchen DaiHuarui ZhangDaogang GuanBaosheng GuoBing HeFangfei LiXiaojuan HeWandong ZhangBao-Ting ZhangGe ZhangAiping LuNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Chao Liang
Jie Li
Cheng Lu
Duoli Xie
Jin Liu
Chuanxin Zhong
Xiaohao Wu
Rongchen Dai
Huarui Zhang
Daogang Guan
Baosheng Guo
Bing He
Fangfei Li
Xiaojuan He
Wandong Zhang
Bao-Ting Zhang
Ge Zhang
Aiping Lu
HIF1α inhibition facilitates Leflunomide-AHR-CRP signaling to attenuate bone erosion in CRP-aberrant rheumatoid arthritis
description Leflunomide is used for the treatment of rheumatoid arthritis. Here, the authors show that effectiveness is limited in patients with higher levels of serum c-reactive protein (CRP). Using animal models, they show that higher CRP induces HIF1a expression, which in turn interferes with Leflunomide signalling, and that effectiveness of the drug is restored when HIF1a is pharmacologically inhibited.
format article
author Chao Liang
Jie Li
Cheng Lu
Duoli Xie
Jin Liu
Chuanxin Zhong
Xiaohao Wu
Rongchen Dai
Huarui Zhang
Daogang Guan
Baosheng Guo
Bing He
Fangfei Li
Xiaojuan He
Wandong Zhang
Bao-Ting Zhang
Ge Zhang
Aiping Lu
author_facet Chao Liang
Jie Li
Cheng Lu
Duoli Xie
Jin Liu
Chuanxin Zhong
Xiaohao Wu
Rongchen Dai
Huarui Zhang
Daogang Guan
Baosheng Guo
Bing He
Fangfei Li
Xiaojuan He
Wandong Zhang
Bao-Ting Zhang
Ge Zhang
Aiping Lu
author_sort Chao Liang
title HIF1α inhibition facilitates Leflunomide-AHR-CRP signaling to attenuate bone erosion in CRP-aberrant rheumatoid arthritis
title_short HIF1α inhibition facilitates Leflunomide-AHR-CRP signaling to attenuate bone erosion in CRP-aberrant rheumatoid arthritis
title_full HIF1α inhibition facilitates Leflunomide-AHR-CRP signaling to attenuate bone erosion in CRP-aberrant rheumatoid arthritis
title_fullStr HIF1α inhibition facilitates Leflunomide-AHR-CRP signaling to attenuate bone erosion in CRP-aberrant rheumatoid arthritis
title_full_unstemmed HIF1α inhibition facilitates Leflunomide-AHR-CRP signaling to attenuate bone erosion in CRP-aberrant rheumatoid arthritis
title_sort hif1α inhibition facilitates leflunomide-ahr-crp signaling to attenuate bone erosion in crp-aberrant rheumatoid arthritis
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/efd52d5facbd414982f94122c9661d92
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