Gender-related differences in the dysfunctional resting networks of migraine suffers.

<h4>Background</h4>Migraine shows gender-specific incidence and has a higher prevalence in females. However, little is known about gender-related differences in dysfunctional brain organization, which may account for gender-specific vulnerability and characteristics of migraine. In this...

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Autores principales:	Jixin Liu, Wei Qin, Jiaofen Nan, Jing Li, Kai Yuan, Ling Zhao, Fang Zeng, Jinbo Sun, Dahua Yu, Minghao Dong, Peng Liu, Karen M von Deneen, Qiyong Gong, Fanrong Liang, Jie Tian
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/efd5f19838b444d48bb165b048dbe30b
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spelling	oai:doaj.org-article:efd5f19838b444d48bb165b048dbe30b2021-11-18T07:35:08ZGender-related differences in the dysfunctional resting networks of migraine suffers.1932-620310.1371/journal.pone.0027049https://doaj.org/article/efd5f19838b444d48bb165b048dbe30b2011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22073251/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Migraine shows gender-specific incidence and has a higher prevalence in females. However, little is known about gender-related differences in dysfunctional brain organization, which may account for gender-specific vulnerability and characteristics of migraine. In this study, we considered gender-related differences in the topological property of resting functional networks.<h4>Methodology/principal findings</h4>Data was obtained from 38 migraine patients (18 males and 20 females) and 38 healthy subjects (18 males and 20 females). We used the graph theory analysis, which becomes a powerful tool in investigating complex brain networks on a whole brain scale and could describe functional interactions between brain regions. Using this approach, we compared the brain functional networks between these two groups, and several network properties were investigated, such as small-worldness, network resilience, nodal centrality, and interregional connections. In our findings, these network characters were all disrupted in patients suffering from chronic migraine. More importantly, these functional damages in the migraine-affected brain had a skewed balance between males and females. In female patients, brain functional networks showed worse resilience, more regions exhibited decreased nodal centrality, and more functional connections revealed abnormalities than in male patients.<h4>Conclusions</h4>These results indicated that migraine may have an additional influence on females and lead to more dysfunctional organization in their resting functional networks.Jixin LiuWei QinJiaofen NanJing LiKai YuanLing ZhaoFang ZengJinbo SunDahua YuMinghao DongPeng LiuKaren M von DeneenQiyong GongFanrong LiangJie TianPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 11, p e27049 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jixin Liu Wei Qin Jiaofen Nan Jing Li Kai Yuan Ling Zhao Fang Zeng Jinbo Sun Dahua Yu Minghao Dong Peng Liu Karen M von Deneen Qiyong Gong Fanrong Liang Jie Tian Gender-related differences in the dysfunctional resting networks of migraine suffers.
description	<h4>Background</h4>Migraine shows gender-specific incidence and has a higher prevalence in females. However, little is known about gender-related differences in dysfunctional brain organization, which may account for gender-specific vulnerability and characteristics of migraine. In this study, we considered gender-related differences in the topological property of resting functional networks.<h4>Methodology/principal findings</h4>Data was obtained from 38 migraine patients (18 males and 20 females) and 38 healthy subjects (18 males and 20 females). We used the graph theory analysis, which becomes a powerful tool in investigating complex brain networks on a whole brain scale and could describe functional interactions between brain regions. Using this approach, we compared the brain functional networks between these two groups, and several network properties were investigated, such as small-worldness, network resilience, nodal centrality, and interregional connections. In our findings, these network characters were all disrupted in patients suffering from chronic migraine. More importantly, these functional damages in the migraine-affected brain had a skewed balance between males and females. In female patients, brain functional networks showed worse resilience, more regions exhibited decreased nodal centrality, and more functional connections revealed abnormalities than in male patients.<h4>Conclusions</h4>These results indicated that migraine may have an additional influence on females and lead to more dysfunctional organization in their resting functional networks.
format	article
author	Jixin Liu Wei Qin Jiaofen Nan Jing Li Kai Yuan Ling Zhao Fang Zeng Jinbo Sun Dahua Yu Minghao Dong Peng Liu Karen M von Deneen Qiyong Gong Fanrong Liang Jie Tian
author_facet	Jixin Liu Wei Qin Jiaofen Nan Jing Li Kai Yuan Ling Zhao Fang Zeng Jinbo Sun Dahua Yu Minghao Dong Peng Liu Karen M von Deneen Qiyong Gong Fanrong Liang Jie Tian
author_sort	Jixin Liu
title	Gender-related differences in the dysfunctional resting networks of migraine suffers.
title_short	Gender-related differences in the dysfunctional resting networks of migraine suffers.
title_full	Gender-related differences in the dysfunctional resting networks of migraine suffers.
title_fullStr	Gender-related differences in the dysfunctional resting networks of migraine suffers.
title_full_unstemmed	Gender-related differences in the dysfunctional resting networks of migraine suffers.
title_sort	gender-related differences in the dysfunctional resting networks of migraine suffers.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/efd5f19838b444d48bb165b048dbe30b
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Gender-related differences in the dysfunctional resting networks of migraine suffers.

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