PARylation prevents the proteasomal degradation of topoisomerase I DNA-protein crosslinks and induces their deubiquitylation

TOP1 resolves DNA supercoils by forming cleavage complexes (TOP1cc) that are trapped by TOP1 inhibitors. Here the authors provide insights into the mechanistic understanding of TOP1cc PARylation, showing that inhibition of PARG results in stabilization of TOP1cc PARylation that blocks the proteasoma...

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Main Authors:	Yilun Sun, Jiji Chen, Shar-yin N. Huang, Yijun P. Su, Wenjie Wang, Keli Agama, Sourav Saha, Lisa M. Jenkins, John M. Pascal, Yves Pommier
Format:	article
Language:	EN
Published:	Nature Portfolio 2021
Subjects:	Science Q
Online Access:	https://doaj.org/article/efd9b3f404b3443ca49e78b32652785a
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spelling	oai:doaj.org-article:efd9b3f404b3443ca49e78b32652785a2021-12-02T15:10:47ZPARylation prevents the proteasomal degradation of topoisomerase I DNA-protein crosslinks and induces their deubiquitylation10.1038/s41467-021-25252-92041-1723https://doaj.org/article/efd9b3f404b3443ca49e78b32652785a2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25252-9https://doaj.org/toc/2041-1723TOP1 resolves DNA supercoils by forming cleavage complexes (TOP1cc) that are trapped by TOP1 inhibitors. Here the authors provide insights into the mechanistic understanding of TOP1cc PARylation, showing that inhibition of PARG results in stabilization of TOP1cc PARylation that blocks the proteasomal degradation of TOP1cc.Yilun SunJiji ChenShar-yin N. HuangYijun P. SuWenjie WangKeli AgamaSourav SahaLisa M. JenkinsJohn M. PascalYves PommierNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yilun Sun Jiji Chen Shar-yin N. Huang Yijun P. Su Wenjie Wang Keli Agama Sourav Saha Lisa M. Jenkins John M. Pascal Yves Pommier PARylation prevents the proteasomal degradation of topoisomerase I DNA-protein crosslinks and induces their deubiquitylation
description	TOP1 resolves DNA supercoils by forming cleavage complexes (TOP1cc) that are trapped by TOP1 inhibitors. Here the authors provide insights into the mechanistic understanding of TOP1cc PARylation, showing that inhibition of PARG results in stabilization of TOP1cc PARylation that blocks the proteasomal degradation of TOP1cc.
format	article
author	Yilun Sun Jiji Chen Shar-yin N. Huang Yijun P. Su Wenjie Wang Keli Agama Sourav Saha Lisa M. Jenkins John M. Pascal Yves Pommier
author_facet	Yilun Sun Jiji Chen Shar-yin N. Huang Yijun P. Su Wenjie Wang Keli Agama Sourav Saha Lisa M. Jenkins John M. Pascal Yves Pommier
author_sort	Yilun Sun
title	PARylation prevents the proteasomal degradation of topoisomerase I DNA-protein crosslinks and induces their deubiquitylation
title_short	PARylation prevents the proteasomal degradation of topoisomerase I DNA-protein crosslinks and induces their deubiquitylation
title_full	PARylation prevents the proteasomal degradation of topoisomerase I DNA-protein crosslinks and induces their deubiquitylation
title_fullStr	PARylation prevents the proteasomal degradation of topoisomerase I DNA-protein crosslinks and induces their deubiquitylation
title_full_unstemmed	PARylation prevents the proteasomal degradation of topoisomerase I DNA-protein crosslinks and induces their deubiquitylation
title_sort	parylation prevents the proteasomal degradation of topoisomerase i dna-protein crosslinks and induces their deubiquitylation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/efd9b3f404b3443ca49e78b32652785a
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PARylation prevents the proteasomal degradation of topoisomerase I DNA-protein crosslinks and induces their deubiquitylation

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