PARylation prevents the proteasomal degradation of topoisomerase I DNA-protein crosslinks and induces their deubiquitylation

TOP1 resolves DNA supercoils by forming cleavage complexes (TOP1cc) that are trapped by TOP1 inhibitors. Here the authors provide insights into the mechanistic understanding of TOP1cc PARylation, showing that inhibition of PARG results in stabilization of TOP1cc PARylation that blocks the proteasoma...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Yilun Sun, Jiji Chen, Shar-yin N. Huang, Yijun P. Su, Wenjie Wang, Keli Agama, Sourav Saha, Lisa M. Jenkins, John M. Pascal, Yves Pommier
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Q
Acceso en línea:https://doaj.org/article/efd9b3f404b3443ca49e78b32652785a
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:efd9b3f404b3443ca49e78b32652785a
record_format dspace
spelling oai:doaj.org-article:efd9b3f404b3443ca49e78b32652785a2021-12-02T15:10:47ZPARylation prevents the proteasomal degradation of topoisomerase I DNA-protein crosslinks and induces their deubiquitylation10.1038/s41467-021-25252-92041-1723https://doaj.org/article/efd9b3f404b3443ca49e78b32652785a2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25252-9https://doaj.org/toc/2041-1723TOP1 resolves DNA supercoils by forming cleavage complexes (TOP1cc) that are trapped by TOP1 inhibitors. Here the authors provide insights into the mechanistic understanding of TOP1cc PARylation, showing that inhibition of PARG results in stabilization of TOP1cc PARylation that blocks the proteasomal degradation of TOP1cc.Yilun SunJiji ChenShar-yin N. HuangYijun P. SuWenjie WangKeli AgamaSourav SahaLisa M. JenkinsJohn M. PascalYves PommierNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Yilun Sun
Jiji Chen
Shar-yin N. Huang
Yijun P. Su
Wenjie Wang
Keli Agama
Sourav Saha
Lisa M. Jenkins
John M. Pascal
Yves Pommier
PARylation prevents the proteasomal degradation of topoisomerase I DNA-protein crosslinks and induces their deubiquitylation
description TOP1 resolves DNA supercoils by forming cleavage complexes (TOP1cc) that are trapped by TOP1 inhibitors. Here the authors provide insights into the mechanistic understanding of TOP1cc PARylation, showing that inhibition of PARG results in stabilization of TOP1cc PARylation that blocks the proteasomal degradation of TOP1cc.
format article
author Yilun Sun
Jiji Chen
Shar-yin N. Huang
Yijun P. Su
Wenjie Wang
Keli Agama
Sourav Saha
Lisa M. Jenkins
John M. Pascal
Yves Pommier
author_facet Yilun Sun
Jiji Chen
Shar-yin N. Huang
Yijun P. Su
Wenjie Wang
Keli Agama
Sourav Saha
Lisa M. Jenkins
John M. Pascal
Yves Pommier
author_sort Yilun Sun
title PARylation prevents the proteasomal degradation of topoisomerase I DNA-protein crosslinks and induces their deubiquitylation
title_short PARylation prevents the proteasomal degradation of topoisomerase I DNA-protein crosslinks and induces their deubiquitylation
title_full PARylation prevents the proteasomal degradation of topoisomerase I DNA-protein crosslinks and induces their deubiquitylation
title_fullStr PARylation prevents the proteasomal degradation of topoisomerase I DNA-protein crosslinks and induces their deubiquitylation
title_full_unstemmed PARylation prevents the proteasomal degradation of topoisomerase I DNA-protein crosslinks and induces their deubiquitylation
title_sort parylation prevents the proteasomal degradation of topoisomerase i dna-protein crosslinks and induces their deubiquitylation
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/efd9b3f404b3443ca49e78b32652785a
work_keys_str_mv AT yilunsun parylationpreventstheproteasomaldegradationoftopoisomeraseidnaproteincrosslinksandinducestheirdeubiquitylation
AT jijichen parylationpreventstheproteasomaldegradationoftopoisomeraseidnaproteincrosslinksandinducestheirdeubiquitylation
AT sharyinnhuang parylationpreventstheproteasomaldegradationoftopoisomeraseidnaproteincrosslinksandinducestheirdeubiquitylation
AT yijunpsu parylationpreventstheproteasomaldegradationoftopoisomeraseidnaproteincrosslinksandinducestheirdeubiquitylation
AT wenjiewang parylationpreventstheproteasomaldegradationoftopoisomeraseidnaproteincrosslinksandinducestheirdeubiquitylation
AT keliagama parylationpreventstheproteasomaldegradationoftopoisomeraseidnaproteincrosslinksandinducestheirdeubiquitylation
AT souravsaha parylationpreventstheproteasomaldegradationoftopoisomeraseidnaproteincrosslinksandinducestheirdeubiquitylation
AT lisamjenkins parylationpreventstheproteasomaldegradationoftopoisomeraseidnaproteincrosslinksandinducestheirdeubiquitylation
AT johnmpascal parylationpreventstheproteasomaldegradationoftopoisomeraseidnaproteincrosslinksandinducestheirdeubiquitylation
AT yvespommier parylationpreventstheproteasomaldegradationoftopoisomeraseidnaproteincrosslinksandinducestheirdeubiquitylation
_version_ 1718387728590045184