PARylation prevents the proteasomal degradation of topoisomerase I DNA-protein crosslinks and induces their deubiquitylation
TOP1 resolves DNA supercoils by forming cleavage complexes (TOP1cc) that are trapped by TOP1 inhibitors. Here the authors provide insights into the mechanistic understanding of TOP1cc PARylation, showing that inhibition of PARG results in stabilization of TOP1cc PARylation that blocks the proteasoma...
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2021
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oai:doaj.org-article:efd9b3f404b3443ca49e78b32652785a2021-12-02T15:10:47ZPARylation prevents the proteasomal degradation of topoisomerase I DNA-protein crosslinks and induces their deubiquitylation10.1038/s41467-021-25252-92041-1723https://doaj.org/article/efd9b3f404b3443ca49e78b32652785a2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25252-9https://doaj.org/toc/2041-1723TOP1 resolves DNA supercoils by forming cleavage complexes (TOP1cc) that are trapped by TOP1 inhibitors. Here the authors provide insights into the mechanistic understanding of TOP1cc PARylation, showing that inhibition of PARG results in stabilization of TOP1cc PARylation that blocks the proteasomal degradation of TOP1cc.Yilun SunJiji ChenShar-yin N. HuangYijun P. SuWenjie WangKeli AgamaSourav SahaLisa M. JenkinsJohn M. PascalYves PommierNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021) |
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Science Q Yilun Sun Jiji Chen Shar-yin N. Huang Yijun P. Su Wenjie Wang Keli Agama Sourav Saha Lisa M. Jenkins John M. Pascal Yves Pommier PARylation prevents the proteasomal degradation of topoisomerase I DNA-protein crosslinks and induces their deubiquitylation |
description |
TOP1 resolves DNA supercoils by forming cleavage complexes (TOP1cc) that are trapped by TOP1 inhibitors. Here the authors provide insights into the mechanistic understanding of TOP1cc PARylation, showing that inhibition of PARG results in stabilization of TOP1cc PARylation that blocks the proteasomal degradation of TOP1cc. |
format |
article |
author |
Yilun Sun Jiji Chen Shar-yin N. Huang Yijun P. Su Wenjie Wang Keli Agama Sourav Saha Lisa M. Jenkins John M. Pascal Yves Pommier |
author_facet |
Yilun Sun Jiji Chen Shar-yin N. Huang Yijun P. Su Wenjie Wang Keli Agama Sourav Saha Lisa M. Jenkins John M. Pascal Yves Pommier |
author_sort |
Yilun Sun |
title |
PARylation prevents the proteasomal degradation of topoisomerase I DNA-protein crosslinks and induces their deubiquitylation |
title_short |
PARylation prevents the proteasomal degradation of topoisomerase I DNA-protein crosslinks and induces their deubiquitylation |
title_full |
PARylation prevents the proteasomal degradation of topoisomerase I DNA-protein crosslinks and induces their deubiquitylation |
title_fullStr |
PARylation prevents the proteasomal degradation of topoisomerase I DNA-protein crosslinks and induces their deubiquitylation |
title_full_unstemmed |
PARylation prevents the proteasomal degradation of topoisomerase I DNA-protein crosslinks and induces their deubiquitylation |
title_sort |
parylation prevents the proteasomal degradation of topoisomerase i dna-protein crosslinks and induces their deubiquitylation |
publisher |
Nature Portfolio |
publishDate |
2021 |
url |
https://doaj.org/article/efd9b3f404b3443ca49e78b32652785a |
work_keys_str_mv |
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