Anti-tumour activity of deer growing antlers and its potential applications in the treatment of malignant gliomas

Abstract A recent study showed that antlers have evolved a high rate of growth due to the expression of proto-oncogenes and that they have also evolved to express several tumour suppressor genes to control the risk of cancer. This may explain why deer antler velvet (DAV) extract shows anti-tumour ac...

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Autores principales:	Louis Chonco, Tomás Landete-Castillejos, Gemma Serrano-Heras, Martina Pérez Serrano, Francisco Javier Pérez-Barbería, Carlos González-Armesto, Andrés García, Carlos de Cabo, Jose Manuel Lorenzo, Chunyi Li, Tomás Segura
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/efda010079f44fdd84182f3259c0c925
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spelling	oai:doaj.org-article:efda010079f44fdd84182f3259c0c9252021-12-02T15:12:55ZAnti-tumour activity of deer growing antlers and its potential applications in the treatment of malignant gliomas10.1038/s41598-020-79779-w2045-2322https://doaj.org/article/efda010079f44fdd84182f3259c0c9252021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79779-whttps://doaj.org/toc/2045-2322Abstract A recent study showed that antlers have evolved a high rate of growth due to the expression of proto-oncogenes and that they have also evolved to express several tumour suppressor genes to control the risk of cancer. This may explain why deer antler velvet (DAV) extract shows anti-tumour activity. The fast growth of antler innervation through the velvet in close association to blood vessels provides a unique environment to study the fast but non-cancerous proliferation of heterogeneous cell populations. We set out to study the anti-cancer effect of DAV in glioblastoma (GB) cell lines in comparison with temozolomide, a chemotherapeutic drug used to treat high-grade brain tumours. Here we report, for the first time, that DAV extract from the tip, but not from mid-parts of the antler, exhibits an anti-tumour effect in GB cell lines (T98G and A172) while being non-toxic in non-cancerous cell lines (HEK293 and HACAT). In T98G cells, DAV treatment showed reduced proliferation (37.5%) and colony-formation capacity (84%), inhibited migration (39%), induced changes in cell cycle progression, and promoted apoptosis. The anticancer activity of DAV extract as demonstrated by these results may provide a new therapeutic strategy for GB treatment.Louis ChoncoTomás Landete-CastillejosGemma Serrano-HerasMartina Pérez SerranoFrancisco Javier Pérez-BarberíaCarlos González-ArmestoAndrés GarcíaCarlos de CaboJose Manuel LorenzoChunyi LiTomás SeguraNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Louis Chonco Tomás Landete-Castillejos Gemma Serrano-Heras Martina Pérez Serrano Francisco Javier Pérez-Barbería Carlos González-Armesto Andrés García Carlos de Cabo Jose Manuel Lorenzo Chunyi Li Tomás Segura Anti-tumour activity of deer growing antlers and its potential applications in the treatment of malignant gliomas
description	Abstract A recent study showed that antlers have evolved a high rate of growth due to the expression of proto-oncogenes and that they have also evolved to express several tumour suppressor genes to control the risk of cancer. This may explain why deer antler velvet (DAV) extract shows anti-tumour activity. The fast growth of antler innervation through the velvet in close association to blood vessels provides a unique environment to study the fast but non-cancerous proliferation of heterogeneous cell populations. We set out to study the anti-cancer effect of DAV in glioblastoma (GB) cell lines in comparison with temozolomide, a chemotherapeutic drug used to treat high-grade brain tumours. Here we report, for the first time, that DAV extract from the tip, but not from mid-parts of the antler, exhibits an anti-tumour effect in GB cell lines (T98G and A172) while being non-toxic in non-cancerous cell lines (HEK293 and HACAT). In T98G cells, DAV treatment showed reduced proliferation (37.5%) and colony-formation capacity (84%), inhibited migration (39%), induced changes in cell cycle progression, and promoted apoptosis. The anticancer activity of DAV extract as demonstrated by these results may provide a new therapeutic strategy for GB treatment.
format	article
author	Louis Chonco Tomás Landete-Castillejos Gemma Serrano-Heras Martina Pérez Serrano Francisco Javier Pérez-Barbería Carlos González-Armesto Andrés García Carlos de Cabo Jose Manuel Lorenzo Chunyi Li Tomás Segura
author_facet	Louis Chonco Tomás Landete-Castillejos Gemma Serrano-Heras Martina Pérez Serrano Francisco Javier Pérez-Barbería Carlos González-Armesto Andrés García Carlos de Cabo Jose Manuel Lorenzo Chunyi Li Tomás Segura
author_sort	Louis Chonco
title	Anti-tumour activity of deer growing antlers and its potential applications in the treatment of malignant gliomas
title_short	Anti-tumour activity of deer growing antlers and its potential applications in the treatment of malignant gliomas
title_full	Anti-tumour activity of deer growing antlers and its potential applications in the treatment of malignant gliomas
title_fullStr	Anti-tumour activity of deer growing antlers and its potential applications in the treatment of malignant gliomas
title_full_unstemmed	Anti-tumour activity of deer growing antlers and its potential applications in the treatment of malignant gliomas
title_sort	anti-tumour activity of deer growing antlers and its potential applications in the treatment of malignant gliomas
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/efda010079f44fdd84182f3259c0c925
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Anti-tumour activity of deer growing antlers and its potential applications in the treatment of malignant gliomas

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