The Risk of Nephropathy, Retinopathy, and Leg Amputation in Patients With Diabetes and Hypertension: A Nationwide, Population-Based Retrospective Cohort Study
PurposeTo compare the risks of chronic kidney disease (CKD), end-stage renal disease (ESRD), sight-threatening retinopathy, and leg amputation between patients with diabetes or hypertension.MethodsFrom January 1, 2000, to December 31, 2015, we identified 28943 matched pairs of patients with diabetes...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:efdab3a2675c4ee480bab2f09c31ee4c2021-11-18T07:29:38ZThe Risk of Nephropathy, Retinopathy, and Leg Amputation in Patients With Diabetes and Hypertension: A Nationwide, Population-Based Retrospective Cohort Study1664-239210.3389/fendo.2021.756189https://doaj.org/article/efdab3a2675c4ee480bab2f09c31ee4c2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fendo.2021.756189/fullhttps://doaj.org/toc/1664-2392PurposeTo compare the risks of chronic kidney disease (CKD), end-stage renal disease (ESRD), sight-threatening retinopathy, and leg amputation between patients with diabetes or hypertension.MethodsFrom January 1, 2000, to December 31, 2015, we identified 28943 matched pairs of patients with diabetes with and without subsequent hypertension, 89102 pairs of patients with hypertension with and without subsequent diabetes, and 145294 pairs of patients with coexisting diabetes and hypertension with a previous history of diabetes or hypertension from Taiwan’s National Health Insurance Research Database. Cox proportional-hazard models were used for calculating the risks of CKD, sight-threatening retinopathy, and leg amputation.ResultsThe mean follow-up time of this study in different cohorts was between 3.59 and 4.28 years. In diabetes patients with vs. without subsequent hypertension, hypertension patients with vs. without subsequent diabetes, and comorbid diabetes and hypertension patients with previous diabetes vs. with previous hypertension, the adjusted HRs (95% CIs) for CKD were 2.77 (2.61-2.94), 1.73 (1.68-1.77), and 1.04 (1.02-1.07); for ESRD were 42.38 (22.62-79.4), 2.76 (2.43-3.13), and 0.72 (0.66-0.79); for sight-threatening retinopathy were 2.07 (1.85-2.3), 3.41 (3.14-3.71), and for leg amputation were 1.51 (1.43-1.58); and 4.74 (3.02-7.43), 6.27(4.72-8.31), and 1.19(1.03-1.38).ConclusionsThis study demonstrated that both diabetes and hypertension are risk factors for the development of CKD, retinopathy, and amputation. Tracing subsequent diabetes for patients with hypertension, and hypertension for patients with diabetes are important in clinical settings.Fu-Shun YenJames Cheng-Chung WeiJames Cheng-Chung WeiJames Cheng-Chung WeiYing-Hsiu ShihYing-Hsiu ShihChih-Cheng HsuChih-Cheng HsuChih-Cheng HsuChii-Min HwuChii-Min HwuFrontiers Media S.A.articlechronic kidney diseaseend-stage renal diseasesight-threatening retinopathyleg amputationdiabetes and hypertensionDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENFrontiers in Endocrinology, Vol 12 (2021) |
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EN |
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chronic kidney disease end-stage renal disease sight-threatening retinopathy leg amputation diabetes and hypertension Diseases of the endocrine glands. Clinical endocrinology RC648-665 |
| spellingShingle |
chronic kidney disease end-stage renal disease sight-threatening retinopathy leg amputation diabetes and hypertension Diseases of the endocrine glands. Clinical endocrinology RC648-665 Fu-Shun Yen James Cheng-Chung Wei James Cheng-Chung Wei James Cheng-Chung Wei Ying-Hsiu Shih Ying-Hsiu Shih Chih-Cheng Hsu Chih-Cheng Hsu Chih-Cheng Hsu Chii-Min Hwu Chii-Min Hwu The Risk of Nephropathy, Retinopathy, and Leg Amputation in Patients With Diabetes and Hypertension: A Nationwide, Population-Based Retrospective Cohort Study |
| description |
PurposeTo compare the risks of chronic kidney disease (CKD), end-stage renal disease (ESRD), sight-threatening retinopathy, and leg amputation between patients with diabetes or hypertension.MethodsFrom January 1, 2000, to December 31, 2015, we identified 28943 matched pairs of patients with diabetes with and without subsequent hypertension, 89102 pairs of patients with hypertension with and without subsequent diabetes, and 145294 pairs of patients with coexisting diabetes and hypertension with a previous history of diabetes or hypertension from Taiwan’s National Health Insurance Research Database. Cox proportional-hazard models were used for calculating the risks of CKD, sight-threatening retinopathy, and leg amputation.ResultsThe mean follow-up time of this study in different cohorts was between 3.59 and 4.28 years. In diabetes patients with vs. without subsequent hypertension, hypertension patients with vs. without subsequent diabetes, and comorbid diabetes and hypertension patients with previous diabetes vs. with previous hypertension, the adjusted HRs (95% CIs) for CKD were 2.77 (2.61-2.94), 1.73 (1.68-1.77), and 1.04 (1.02-1.07); for ESRD were 42.38 (22.62-79.4), 2.76 (2.43-3.13), and 0.72 (0.66-0.79); for sight-threatening retinopathy were 2.07 (1.85-2.3), 3.41 (3.14-3.71), and for leg amputation were 1.51 (1.43-1.58); and 4.74 (3.02-7.43), 6.27(4.72-8.31), and 1.19(1.03-1.38).ConclusionsThis study demonstrated that both diabetes and hypertension are risk factors for the development of CKD, retinopathy, and amputation. Tracing subsequent diabetes for patients with hypertension, and hypertension for patients with diabetes are important in clinical settings. |
| format |
article |
| author |
Fu-Shun Yen James Cheng-Chung Wei James Cheng-Chung Wei James Cheng-Chung Wei Ying-Hsiu Shih Ying-Hsiu Shih Chih-Cheng Hsu Chih-Cheng Hsu Chih-Cheng Hsu Chii-Min Hwu Chii-Min Hwu |
| author_facet |
Fu-Shun Yen James Cheng-Chung Wei James Cheng-Chung Wei James Cheng-Chung Wei Ying-Hsiu Shih Ying-Hsiu Shih Chih-Cheng Hsu Chih-Cheng Hsu Chih-Cheng Hsu Chii-Min Hwu Chii-Min Hwu |
| author_sort |
Fu-Shun Yen |
| title |
The Risk of Nephropathy, Retinopathy, and Leg Amputation in Patients With Diabetes and Hypertension: A Nationwide, Population-Based Retrospective Cohort Study |
| title_short |
The Risk of Nephropathy, Retinopathy, and Leg Amputation in Patients With Diabetes and Hypertension: A Nationwide, Population-Based Retrospective Cohort Study |
| title_full |
The Risk of Nephropathy, Retinopathy, and Leg Amputation in Patients With Diabetes and Hypertension: A Nationwide, Population-Based Retrospective Cohort Study |
| title_fullStr |
The Risk of Nephropathy, Retinopathy, and Leg Amputation in Patients With Diabetes and Hypertension: A Nationwide, Population-Based Retrospective Cohort Study |
| title_full_unstemmed |
The Risk of Nephropathy, Retinopathy, and Leg Amputation in Patients With Diabetes and Hypertension: A Nationwide, Population-Based Retrospective Cohort Study |
| title_sort |
risk of nephropathy, retinopathy, and leg amputation in patients with diabetes and hypertension: a nationwide, population-based retrospective cohort study |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/efdab3a2675c4ee480bab2f09c31ee4c |
| work_keys_str_mv |
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