<i>Gloeothece</i> sp.—Exploiting a New Source of Antioxidant, Anti-Inflammatory, and Antitumor Agents
Bioactive lipidic compounds of microalgae, such as polyunsaturated fatty acids (PUFA) and carotenoids, can avoid or treat oxidation-associated conditions and diseases like inflammation or cancer. This study aimed to assess the bioactive potential of lipidic extracts obtained from <i>Gloeothece...
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| Autores principales: | , , , , , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
MDPI AG
2021
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/efde6215f35e457e8b18aacab8436982 |
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| Sumario: | Bioactive lipidic compounds of microalgae, such as polyunsaturated fatty acids (PUFA) and carotenoids, can avoid or treat oxidation-associated conditions and diseases like inflammation or cancer. This study aimed to assess the bioactive potential of lipidic extracts obtained from <i>Gloeothece</i> sp.–using Generally Recognized as Safe (GRAS) solvents like ethanol, acetone, hexane:isopropanol (3:2) (HI) and ethyl lactate. The bioactive potential of extracts was assessed in terms of antioxidant (ABTS<sup>•+</sup>, DPPH<sup>•</sup>, <sup>•</sup>NO and O<sub>2</sub><sup>•</sup>assays), anti-inflammatory (HRBC membrane stabilization and Cox-2 screening assay), and antitumor capacity (death by TUNEL, and anti-proliferative by BrdU incorporation assay in AGS cancer cells); while its composition was characterized in terms of carotenoids and fatty acids, by HPLC-DAD and GC-FID methods, respectively. Results revealed a chemopreventive potential of the HI extract owing to its ability to: (I) scavenge <sup>-</sup>NO<sup>•</sup> radical (IC<sub>50</sub>, 1258 ± 0.353 µg·mL<sup>−1</sup>); (II) inhibit 50% of COX-2 expression at 130.2 ± 7.4 µg·mL<sup>−1</sup>; (III) protect 61.6 ± 9.2% of lysosomes from heat damage, and (IV) induce AGS cell death by 4.2-fold and avoid its proliferation up to 40% in a concentration of 23.2 ± 1.9 µg·mL<sup>−1</sup>. Hence, <i>Gloeothece</i> sp. extracts, namely HI, were revealed to have the potential to be used for nutraceutical purposes. |
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