Highly structured homolog pairing reflects functional organization of the Drosophila genome

Trans-homolog interactions, such as homolog pairing, are highly structured and associated with gene function in Drosophila cells. Here, the authors use haplotype-resolved Hi-C to identify genome-wide trans-homolog interactions in a Drosophila hybrid cell line and investigate their patterns and funct...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jumana AlHaj Abed, Jelena Erceg, Anton Goloborodko, Son C. Nguyen, Ruth B. McCole, Wren Saylor, Geoffrey Fudenberg, Bryan R. Lajoie, Job Dekker, Leonid A. Mirny, C.-ting Wu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/efe9374eb24d45d29061d1cd4af22228
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:efe9374eb24d45d29061d1cd4af22228
record_format	dspace
spelling	oai:doaj.org-article:efe9374eb24d45d29061d1cd4af222282021-12-02T17:32:08ZHighly structured homolog pairing reflects functional organization of the Drosophila genome10.1038/s41467-019-12208-32041-1723https://doaj.org/article/efe9374eb24d45d29061d1cd4af222282019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12208-3https://doaj.org/toc/2041-1723Trans-homolog interactions, such as homolog pairing, are highly structured and associated with gene function in Drosophila cells. Here, the authors use haplotype-resolved Hi-C to identify genome-wide trans-homolog interactions in a Drosophila hybrid cell line and investigate their patterns and functional roles.Jumana AlHaj AbedJelena ErcegAnton GoloborodkoSon C. NguyenRuth B. McColeWren SaylorGeoffrey FudenbergBryan R. LajoieJob DekkerLeonid A. MirnyC.-ting WuNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jumana AlHaj Abed Jelena Erceg Anton Goloborodko Son C. Nguyen Ruth B. McCole Wren Saylor Geoffrey Fudenberg Bryan R. Lajoie Job Dekker Leonid A. Mirny C.-ting Wu Highly structured homolog pairing reflects functional organization of the Drosophila genome
description	Trans-homolog interactions, such as homolog pairing, are highly structured and associated with gene function in Drosophila cells. Here, the authors use haplotype-resolved Hi-C to identify genome-wide trans-homolog interactions in a Drosophila hybrid cell line and investigate their patterns and functional roles.
format	article
author	Jumana AlHaj Abed Jelena Erceg Anton Goloborodko Son C. Nguyen Ruth B. McCole Wren Saylor Geoffrey Fudenberg Bryan R. Lajoie Job Dekker Leonid A. Mirny C.-ting Wu
author_facet	Jumana AlHaj Abed Jelena Erceg Anton Goloborodko Son C. Nguyen Ruth B. McCole Wren Saylor Geoffrey Fudenberg Bryan R. Lajoie Job Dekker Leonid A. Mirny C.-ting Wu
author_sort	Jumana AlHaj Abed
title	Highly structured homolog pairing reflects functional organization of the Drosophila genome
title_short	Highly structured homolog pairing reflects functional organization of the Drosophila genome
title_full	Highly structured homolog pairing reflects functional organization of the Drosophila genome
title_fullStr	Highly structured homolog pairing reflects functional organization of the Drosophila genome
title_full_unstemmed	Highly structured homolog pairing reflects functional organization of the Drosophila genome
title_sort	highly structured homolog pairing reflects functional organization of the drosophila genome
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/efe9374eb24d45d29061d1cd4af22228
work_keys_str_mv	AT jumanaalhajabed highlystructuredhomologpairingreflectsfunctionalorganizationofthedrosophilagenome AT jelenaerceg highlystructuredhomologpairingreflectsfunctionalorganizationofthedrosophilagenome AT antongoloborodko highlystructuredhomologpairingreflectsfunctionalorganizationofthedrosophilagenome AT soncnguyen highlystructuredhomologpairingreflectsfunctionalorganizationofthedrosophilagenome AT ruthbmccole highlystructuredhomologpairingreflectsfunctionalorganizationofthedrosophilagenome AT wrensaylor highlystructuredhomologpairingreflectsfunctionalorganizationofthedrosophilagenome AT geoffreyfudenberg highlystructuredhomologpairingreflectsfunctionalorganizationofthedrosophilagenome AT bryanrlajoie highlystructuredhomologpairingreflectsfunctionalorganizationofthedrosophilagenome AT jobdekker highlystructuredhomologpairingreflectsfunctionalorganizationofthedrosophilagenome AT leonidamirny highlystructuredhomologpairingreflectsfunctionalorganizationofthedrosophilagenome AT ctingwu highlystructuredhomologpairingreflectsfunctionalorganizationofthedrosophilagenome
_version_	1718380406349234176

Highly structured homolog pairing reflects functional organization of the Drosophila genome

Ejemplares similares