Role of the motor cortex in the generation of classically conditioned eyelid and vibrissae responses

Abstract The eyelid motor system has been used for years as an experimental model for studying the neuronal mechanisms underlying motor and cognitive learning, mainly with classical conditioning procedures. Nonetheless, it is not known yet which brain structures, or neuronal mechanisms, are responsi...

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Autores principales:	Juan C. López-Ramos, José M. Delgado-García
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/efeb97d994914f0687fae0802628ff9b
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spelling	oai:doaj.org-article:efeb97d994914f0687fae0802628ff9b2021-12-02T17:08:23ZRole of the motor cortex in the generation of classically conditioned eyelid and vibrissae responses10.1038/s41598-021-96153-62045-2322https://doaj.org/article/efeb97d994914f0687fae0802628ff9b2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96153-6https://doaj.org/toc/2045-2322Abstract The eyelid motor system has been used for years as an experimental model for studying the neuronal mechanisms underlying motor and cognitive learning, mainly with classical conditioning procedures. Nonetheless, it is not known yet which brain structures, or neuronal mechanisms, are responsible for the acquisition, storage, and expression of these motor responses. Here, we studied the temporal correlation between unitary activities of identified eyelid and vibrissae motor cortex neurons and the electromyographic activity of the orbicularis oculi and vibrissae muscles and magnetically recorded eyelid positions during classical conditioning of eyelid and vibrissae responses, using both delay and trace conditioning paradigms in behaving mice. We also studied the involvement of motor cortex neurons in reflexively evoked eyelid responses and the kinematics and oscillatory properties of eyelid movements evoked by motor cortex microstimulation. Results show the involvement of the motor cortex in the performance of conditioned responses elicited during the classical conditioning task. However, a timing correlation analysis showed that both electromyographic activities preceded the firing of motor cortex neurons, which must therefore be related more with the reinforcement and/or proper performance of the conditioned responses than with their acquisition and storage.Juan C. López-RamosJosé M. Delgado-GarcíaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Juan C. López-Ramos José M. Delgado-García Role of the motor cortex in the generation of classically conditioned eyelid and vibrissae responses
description	Abstract The eyelid motor system has been used for years as an experimental model for studying the neuronal mechanisms underlying motor and cognitive learning, mainly with classical conditioning procedures. Nonetheless, it is not known yet which brain structures, or neuronal mechanisms, are responsible for the acquisition, storage, and expression of these motor responses. Here, we studied the temporal correlation between unitary activities of identified eyelid and vibrissae motor cortex neurons and the electromyographic activity of the orbicularis oculi and vibrissae muscles and magnetically recorded eyelid positions during classical conditioning of eyelid and vibrissae responses, using both delay and trace conditioning paradigms in behaving mice. We also studied the involvement of motor cortex neurons in reflexively evoked eyelid responses and the kinematics and oscillatory properties of eyelid movements evoked by motor cortex microstimulation. Results show the involvement of the motor cortex in the performance of conditioned responses elicited during the classical conditioning task. However, a timing correlation analysis showed that both electromyographic activities preceded the firing of motor cortex neurons, which must therefore be related more with the reinforcement and/or proper performance of the conditioned responses than with their acquisition and storage.
format	article
author	Juan C. López-Ramos José M. Delgado-García
author_facet	Juan C. López-Ramos José M. Delgado-García
author_sort	Juan C. López-Ramos
title	Role of the motor cortex in the generation of classically conditioned eyelid and vibrissae responses
title_short	Role of the motor cortex in the generation of classically conditioned eyelid and vibrissae responses
title_full	Role of the motor cortex in the generation of classically conditioned eyelid and vibrissae responses
title_fullStr	Role of the motor cortex in the generation of classically conditioned eyelid and vibrissae responses
title_full_unstemmed	Role of the motor cortex in the generation of classically conditioned eyelid and vibrissae responses
title_sort	role of the motor cortex in the generation of classically conditioned eyelid and vibrissae responses
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/efeb97d994914f0687fae0802628ff9b
work_keys_str_mv	AT juanclopezramos roleofthemotorcortexinthegenerationofclassicallyconditionedeyelidandvibrissaeresponses AT josemdelgadogarcia roleofthemotorcortexinthegenerationofclassicallyconditionedeyelidandvibrissaeresponses
_version_	1718381591303028736

Role of the motor cortex in the generation of classically conditioned eyelid and vibrissae responses

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